CHRM4 — 51 ClinVar variants
All ClinVar germline CHRM4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 50 flagged for review →
1 Likely benign · 50 Uncertain significance
Full CHRM4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 50
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHRM4 p.Ala263Thr Uncertain significance Single submitter
- CHRM4 p.Ala325Thr Uncertain significance Single submitter
- CHRM4 p.Ala356Thr Uncertain significance Single submitter
- CHRM4 p.Arg17His Uncertain significance Single submitter
- CHRM4 p.Arg264Gly Uncertain significance Single submitter
- CHRM4 p.Arg268Cys Uncertain significance Single submitter
- CHRM4 p.Arg285Cys Uncertain significance Single submitter
- CHRM4 p.Arg308His Uncertain significance Single submitter
- CHRM4 p.Arg331Trp Uncertain significance Single submitter
- CHRM4 p.Arg368Cys Uncertain significance Single submitter
- CHRM4 p.Arg465Gln Uncertain significance Single submitter
- CHRM4 p.Arg473Gln Uncertain significance Single submitter
- CHRM4 p.Asp78Asn Uncertain significance Single submitter
- CHRM4 p.Gln329His Uncertain significance Single submitter
- CHRM4 p.Glu232Lys Uncertain significance Single submitter
- CHRM4 p.Glu265Gly Uncertain significance Single submitter
- CHRM4 p.Glu265Lys Uncertain significance Single submitter
- CHRM4 p.Glu266Lys Uncertain significance Single submitter
- CHRM4 p.Glu273Ala Uncertain significance Single submitter
- CHRM4 p.Gly366Arg Uncertain significance Single submitter
- CHRM4 p.Ile201Asn Uncertain significance Single submitter
- CHRM4 p.Ile380Met Uncertain significance Single submitter
- CHRM4 p.Leu151Val Uncertain significance Single submitter
- CHRM4 p.Lys341Arg Uncertain significance Single submitter
- CHRM4 p.Met367Thr Uncertain significance Single submitter
- CHRM4 p.Pro234Leu Uncertain significance Single submitter
- CHRM4 p.Pro277Leu Uncertain significance Single submitter
- CHRM4 p.Pro326Leu Uncertain significance Single submitter
- CHRM4 p.Pro364Gln Uncertain significance Single submitter
- CHRM4 p.Ser15Pro Uncertain significance Single submitter
- CHRM4 p.Ser253Arg Uncertain significance Single submitter
- CHRM4 p.Ser428Asn Uncertain significance Single submitter
- CHRM4 p.Thr20Met Uncertain significance Single submitter
- CHRM4 p.Thr212Met Uncertain significance Single submitter
- CHRM4 p.Thr241Met Uncertain significance Single submitter
- CHRM4 p.Thr316Pro Uncertain significance Single submitter
- CHRM4 p.Thr349Arg Uncertain significance Single submitter
- CHRM4 p.Thr363Met Uncertain significance Single submitter
- CHRM4 p.Val103Met Uncertain significance Single submitter
- CHRM4 p.Val175Ala Uncertain significance Single submitter
- CHRM4 p.Val19Leu Uncertain significance Single submitter
- CHRM4 p.Val30Ala Uncertain significance Single submitter
- CHRM4 p.Val354Leu Uncertain significance Single submitter
- CHRM4 p.Val418Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- CHRM4 p.Arg382His Uncertain significance Single submitter
- CHRM4 p.Gly350Asp Uncertain significance Single submitter
- CHRM4 p.Phe204Tyr Uncertain significance Single submitter
- CHRM4 p.Ser224Arg Uncertain significance Single submitter
- CHRM4 p.Thr179Met Uncertain significance Single submitter
- CHRM4 p.Val38Gly Uncertain significance Single submitter
All CHRM4 variants
Likely benign 1
- p.Val254Ile Single submitter
Uncertain significance 50
- p.Ala263Thr Single submitter ⚠
- p.Ala325Thr Single submitter ⚠
- p.Ala356Thr Single submitter ⚠
- p.Arg17His Single submitter ⚠
- p.Arg264Gly Single submitter ⚠
- p.Arg268Cys Single submitter ⚠
- p.Arg285Cys Single submitter ⚠
- p.Arg308His Single submitter ⚠
- p.Arg331Trp Single submitter ⚠
- p.Arg368Cys Single submitter ⚠
- p.Arg382His Single submitter ⚠
- p.Arg465Gln Single submitter ⚠
- p.Arg473Gln Single submitter ⚠
- p.Asp78Asn Single submitter ⚠
- p.Gln329His Single submitter ⚠
- p.Glu232Lys Single submitter ⚠
- p.Glu265Gly Single submitter ⚠
- p.Glu265Lys Single submitter ⚠
- p.Glu266Lys Single submitter ⚠
- p.Glu273Ala Single submitter ⚠
- p.Gly350Asp Single submitter ⚠
- p.Gly366Arg Single submitter ⚠
- p.Ile201Asn Single submitter ⚠
- p.Ile380Met Single submitter ⚠
- p.Leu151Val Single submitter ⚠
- p.Lys341Arg Single submitter ⚠
- p.Met367Thr Single submitter ⚠
- p.Phe204Tyr Single submitter ⚠
- p.Pro234Leu Single submitter ⚠
- p.Pro277Leu Single submitter ⚠
- p.Pro326Leu Single submitter ⚠
- p.Pro364Gln Single submitter ⚠
- p.Ser15Pro Single submitter ⚠
- p.Ser224Arg Single submitter ⚠
- p.Ser253Arg Single submitter ⚠
- p.Ser428Asn Single submitter ⚠
- p.Thr179Met Single submitter ⚠
- p.Thr20Met Single submitter ⚠
- p.Thr212Met Single submitter ⚠
- p.Thr241Met Single submitter ⚠
- p.Thr316Pro Single submitter ⚠
- p.Thr349Arg Single submitter ⚠
- p.Thr363Met Single submitter ⚠
- p.Val103Met Single submitter ⚠
- p.Val175Ala Single submitter ⚠
- p.Val19Leu Single submitter ⚠
- p.Val30Ala Single submitter ⚠
- p.Val354Leu Single submitter ⚠
- p.Val38Gly Single submitter ⚠
- p.Val418Ile Single submitter ⚠