CHRNA10 — 95 ClinVar variants
All ClinVar germline CHRNA10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 84 flagged for review →
7 Likely benign · 88 Uncertain significance
Full CHRNA10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 84
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 65
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHRNA10 p.Ala194Gly Uncertain significance Single submitter
- CHRNA10 p.Ala194Val Uncertain significance Single submitter
- CHRNA10 p.Ala304Val Uncertain significance Single submitter
- CHRNA10 p.Arg105Cys Uncertain significance Single submitter
- CHRNA10 p.Arg143Cys Uncertain significance Single submitter
- CHRNA10 p.Arg185Gln Uncertain significance Single submitter
- CHRNA10 p.Arg187His Uncertain significance Single submitter
- CHRNA10 p.Arg212Cys Uncertain significance Single submitter
- CHRNA10 p.Arg235Cys Uncertain significance Single submitter
- CHRNA10 p.Arg235Leu Uncertain significance Single submitter
- CHRNA10 p.Arg28Gly Uncertain significance Single submitter
- CHRNA10 p.Arg346Trp Uncertain significance Single submitter
- CHRNA10 p.Arg387Gln Uncertain significance Single submitter
- CHRNA10 p.Arg410Gln Uncertain significance Single submitter
- CHRNA10 p.Arg414Cys Uncertain significance Single submitter
- CHRNA10 p.Arg424Cys Uncertain significance Single submitter
- CHRNA10 p.Arg72Trp Uncertain significance Single submitter
- CHRNA10 p.Asn404His Uncertain significance Single submitter
- CHRNA10 p.Asp157Tyr Uncertain significance Single submitter
- CHRNA10 p.Asp50His Uncertain significance Single submitter
- CHRNA10 p.Cys154Trp Uncertain significance Single submitter
- CHRNA10 p.Glu201Lys Uncertain significance Single submitter
- CHRNA10 p.Glu221Lys Uncertain significance Single submitter
- CHRNA10 p.Glu385Lys Uncertain significance Single submitter
- CHRNA10 p.Glu417Gly Uncertain significance Single submitter
- CHRNA10 p.Gly173Ser Uncertain significance Single submitter
- CHRNA10 p.Gly217Ser Uncertain significance Single submitter
- CHRNA10 p.Gly358Arg Uncertain significance Single submitter
- CHRNA10 p.Gly377Ser Uncertain significance Single submitter
- CHRNA10 p.His259Leu Uncertain significance Single submitter
- CHRNA10 p.Ile250Asn Uncertain significance Single submitter
- CHRNA10 p.Ile67Leu Uncertain significance Single submitter
- CHRNA10 p.Ile82Val Uncertain significance Single submitter
- CHRNA10 p.Leu136Arg Uncertain significance Single submitter
- CHRNA10 p.Leu182Arg Uncertain significance Single submitter
- CHRNA10 p.Leu182Pro Uncertain significance Single submitter
- CHRNA10 p.Leu245Pro Uncertain significance Single submitter
- CHRNA10 p.Leu344Val Uncertain significance Single submitter
- CHRNA10 p.Met303Val Uncertain significance Single submitter
- CHRNA10 p.Pro127Leu Uncertain significance Single submitter
- CHRNA10 p.Pro162Gln Uncertain significance Single submitter
- CHRNA10 p.Pro186Leu Uncertain significance Single submitter
- CHRNA10 p.Pro246Ser Uncertain significance Single submitter
- CHRNA10 p.Pro296Gln Uncertain significance Single submitter
- CHRNA10 p.Pro296Leu Uncertain significance Single submitter
- CHRNA10 p.Ser312Leu Uncertain significance Single submitter
- CHRNA10 p.Ser328Arg Uncertain significance Single submitter
- CHRNA10 p.Ser360Phe Uncertain significance Single submitter
- CHRNA10 p.Thr150Arg Uncertain significance Single submitter
- CHRNA10 p.Thr305Ser Uncertain significance Single submitter
- CHRNA10 p.Thr307Asn Uncertain significance Single submitter
- CHRNA10 p.Thr42Ala Uncertain significance Single submitter
- CHRNA10 p.Thr87Lys Uncertain significance Single submitter
- CHRNA10 p.Trp144Arg Uncertain significance Single submitter
- CHRNA10 p.Tyr119His Uncertain significance Single submitter
- CHRNA10 p.Tyr216His Uncertain significance Single submitter
- CHRNA10 p.Tyr302His Uncertain significance Single submitter
- CHRNA10 p.Tyr90His Uncertain significance Single submitter
- CHRNA10 p.Val117Ile Uncertain significance Single submitter
- CHRNA10 p.Val280Gly Uncertain significance Single submitter
- CHRNA10 p.Val295Ala Uncertain significance Single submitter
- CHRNA10 p.Val309Gly Uncertain significance Single submitter
- CHRNA10 p.Val399Leu Uncertain significance Single submitter
- CHRNA10 p.Val57Leu Uncertain significance Single submitter
- CHRNA10 p.Val75Leu Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- CHRNA10 p.Ala254Val Uncertain significance Single submitter
- CHRNA10 p.Arg233His Likely benign Single submitter
- CHRNA10 p.Arg337Lys Uncertain significance Single submitter
- CHRNA10 p.Arg35Cys Uncertain significance Single submitter
- CHRNA10 p.Arg428Cys Uncertain significance Single submitter
- CHRNA10 p.Arg428His Uncertain significance Single submitter
- CHRNA10 p.Arg83Gln Uncertain significance Single submitter
- CHRNA10 p.Asp157Glu Uncertain significance Single submitter
- CHRNA10 p.Asp225Asn Uncertain significance Single submitter
- CHRNA10 p.Asp427Glu Uncertain significance Single submitter
- CHRNA10 p.Gln282Arg Uncertain significance Single submitter
- CHRNA10 p.Glu287Lys Uncertain significance Single submitter
- CHRNA10 p.Gly178Arg Uncertain significance Single submitter
- CHRNA10 p.Gly179Arg Uncertain significance Single submitter
- CHRNA10 p.Phe196Leu Uncertain significance Single submitter
- CHRNA10 p.Phe38Ser Uncertain significance Single submitter
- CHRNA10 p.Pro208Leu Uncertain significance Single submitter
- CHRNA10 p.Thr150Met Uncertain significance Single submitter
- CHRNA10 p.Val156Met Uncertain significance Single submitter
All CHRNA10 variants
Likely benign 7
- p.Arg210Gln Single submitter
- p.Arg233His Single submitter ⚠
- p.Arg391His Single submitter
- p.Arg407His Single submitter
- p.Arg92Gln Single submitter
- p.Lys121= Single submitter
- p.Ala380Val No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 88
- p.Ala191Val Single submitter
- p.Ala194Gly Single submitter ⚠
- p.Ala194Val Single submitter ⚠
- p.Ala254Val Single submitter ⚠
- p.Ala304Val Single submitter ⚠
- p.Arg105Cys Single submitter ⚠
- p.Arg143Cys Single submitter ⚠
- p.Arg155Cys Single submitter
- p.Arg185Gln Single submitter ⚠
- p.Arg187His Single submitter ⚠
- p.Arg212Cys Single submitter ⚠
- p.Arg235Cys Single submitter ⚠
- p.Arg235Leu Single submitter ⚠
- p.Arg28Gly Single submitter ⚠
- p.Arg337Lys Single submitter ⚠
- p.Arg346Trp Single submitter ⚠
- p.Arg35Cys Single submitter ⚠
- p.Arg387Gln Single submitter ⚠
- p.Arg410Gln Single submitter ⚠
- p.Arg414Cys Single submitter ⚠
- p.Arg424Cys Single submitter ⚠
- p.Arg428Cys Single submitter ⚠
- p.Arg428His Single submitter ⚠
- p.Arg72Trp Single submitter ⚠
- p.Arg83Gln Single submitter ⚠
- p.Asn404His Single submitter ⚠
- p.Asp157Glu Single submitter ⚠
- p.Asp157Tyr Single submitter ⚠
- p.Asp225Asn Single submitter ⚠
- p.Asp427Glu Single submitter ⚠
- p.Asp50His Single submitter ⚠
- p.Cys154Trp Single submitter ⚠
- p.Gln282Arg Single submitter ⚠
- p.Glu201Lys Single submitter ⚠
- p.Glu221Lys Single submitter ⚠
- p.Glu287Lys Single submitter ⚠
- p.Glu385Lys Single submitter ⚠
- p.Glu417Gly Single submitter ⚠
- p.Gly173Ser Single submitter ⚠
- p.Gly178Arg Single submitter ⚠
- p.Gly179Arg Single submitter ⚠
- p.Gly217Ser Single submitter ⚠
- p.Gly358Arg Single submitter ⚠
- p.Gly377Ser Single submitter ⚠
- p.His259Leu Single submitter ⚠
- p.Ile250Asn Single submitter ⚠
- p.Ile67Leu Single submitter ⚠
- p.Ile82Val Single submitter ⚠
- p.Leu136Arg Single submitter ⚠
- p.Leu182Arg Single submitter ⚠
- p.Leu182Pro Single submitter ⚠
- p.Leu245Pro Single submitter ⚠
- p.Leu344Val Single submitter ⚠
- p.Met303Val Single submitter ⚠
- p.Phe196Leu Single submitter ⚠
- p.Phe38Ser Single submitter ⚠
- p.Pro127Leu Single submitter ⚠
- p.Pro162Gln Single submitter ⚠
- p.Pro186Leu Single submitter ⚠
- p.Pro208Leu Single submitter ⚠
- p.Pro246Ser Single submitter ⚠
- p.Pro291Leu Single submitter
- p.Pro296Gln Single submitter ⚠
- p.Pro296Leu Single submitter ⚠
- p.Ser312Leu Single submitter ⚠
- p.Ser328Arg Single submitter ⚠
- p.Ser360Phe Single submitter ⚠
- p.Thr150Arg Single submitter ⚠
- p.Thr150Met Single submitter ⚠
- p.Thr305Ser Single submitter ⚠
- p.Thr307Asn Single submitter ⚠
- p.Thr42Ala Single submitter ⚠
- p.Thr87Lys Single submitter ⚠
- p.Trp144Arg Single submitter ⚠
- p.Tyr119His Single submitter ⚠
- p.Tyr216His Single submitter ⚠
- p.Tyr302His Single submitter ⚠
- p.Tyr90His Single submitter ⚠
- p.Val117Ile Single submitter ⚠
- p.Val156Met Single submitter ⚠
- p.Val197Leu Single submitter
- p.Val280Gly Single submitter ⚠
- p.Val295Ala Single submitter ⚠
- p.Val309Gly Single submitter ⚠
- p.Val399Leu Single submitter ⚠
- p.Val57Leu Single submitter ⚠
- p.Val75Leu Single submitter ⚠
- p.Val75Met Single submitter