CHRNA6 — 52 ClinVar variants
All ClinVar germline CHRNA6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
4 Benign · 3 Likely benign · 45 Uncertain significance
Full CHRNA6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHRNA6 p.Arg109His Uncertain significance Single submitter
- CHRNA6 p.Arg330His Uncertain significance Single submitter
- CHRNA6 p.Arg376Gly Uncertain significance Single submitter
- CHRNA6 p.Asn402His Uncertain significance Single submitter
- CHRNA6 p.Asp119Asn Uncertain significance Single submitter
- CHRNA6 p.Cys15Gly Uncertain significance Single submitter
- CHRNA6 p.Gln351Arg Uncertain significance Single submitter
- CHRNA6 p.Gln437Arg Uncertain significance Single submitter
- CHRNA6 p.Glu305Lys Uncertain significance Single submitter
- CHRNA6 p.Ile327Thr Uncertain significance Single submitter
- CHRNA6 p.Leu282Pro Uncertain significance Single submitter
- CHRNA6 p.Leu308Gln Uncertain significance Single submitter
- CHRNA6 p.Leu84Val Uncertain significance Single submitter
- CHRNA6 p.Lys26Asn Uncertain significance Single submitter
- CHRNA6 p.Lys26Thr Uncertain significance Single submitter
- CHRNA6 p.Lys342Arg Uncertain significance Single submitter
- CHRNA6 p.Met100Val Uncertain significance Single submitter
- CHRNA6 p.Phe396Leu Uncertain significance Single submitter
- CHRNA6 p.Pro250Leu Uncertain significance Single submitter
- CHRNA6 p.Pro265Ser Uncertain significance Single submitter
- CHRNA6 p.Pro415Leu Uncertain significance Single submitter
- CHRNA6 p.Ser295Phe Uncertain significance Single submitter
- CHRNA6 p.Thr296Ile Uncertain significance Single submitter
- CHRNA6 p.Thr331Ile Uncertain significance Single submitter
- CHRNA6 p.Trp456Cys Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- CHRNA6 p.Arg36Thr Benign Single submitter
- CHRNA6 p.Arg96Cys Uncertain significance Single submitter
- CHRNA6 p.Asp129Asn Uncertain significance Single submitter
- CHRNA6 p.Asp187Ala Uncertain significance Single submitter
- CHRNA6 p.Glu453Gly Uncertain significance Single submitter
- CHRNA6 p.Ile312Met Uncertain significance Single submitter
- CHRNA6 p.Leu307Val Uncertain significance Single submitter
- CHRNA6 p.Met311Leu Uncertain significance Single submitter
- CHRNA6 p.Ser173Phe Uncertain significance Single submitter
- CHRNA6 p.Ser426Trp Uncertain significance Single submitter
- CHRNA6 p.Ser43Phe Uncertain significance Single submitter
- CHRNA6 p.Thr147Ser Uncertain significance Single submitter
- CHRNA6 p.Thr310Pro Uncertain significance Single submitter
- CHRNA6 p.Thr336Ala Uncertain significance Single submitter
- CHRNA6 p.Thr60Met Uncertain significance Single submitter
- CHRNA6 p.Trp17Arg Uncertain significance Single submitter
- CHRNA6 p.Tyr263His Uncertain significance Single submitter
- CHRNA6 p.Val370Met Uncertain significance Single submitter
- CHRNA6 p.Val429Ala Uncertain significance Single submitter
- CHRNA6 p.Val463Ala Uncertain significance Single submitter
- CHRNA6 p.Val73Met Uncertain significance Single submitter
All CHRNA6 variants
Benign 4
- p.Ser266= Multiple submitters
- p.Arg36Thr Single submitter ⚠
- p.Thr244= Single submitter
- p.Thr273= Single submitter
Likely benign 3
- p.Arg339Lys Single submitter
- p.Leu354Met Single submitter
- p.Thr333Ala Single submitter
Uncertain significance 45
- p.Arg109His Single submitter ⚠
- p.Arg330His Single submitter ⚠
- p.Arg376Gly Single submitter ⚠
- p.Arg96Cys Single submitter ⚠
- p.Asn402His Single submitter ⚠
- p.Asp119Asn Single submitter ⚠
- p.Asp129Asn Single submitter ⚠
- p.Asp187Ala Single submitter ⚠
- p.Cys15Gly Single submitter ⚠
- p.Gln351Arg Single submitter ⚠
- p.Gln437Arg Single submitter ⚠
- p.Glu305Lys Single submitter ⚠
- p.Glu453Gly Single submitter ⚠
- p.Ile312Met Single submitter ⚠
- p.Ile327Thr Single submitter ⚠
- p.Leu282Pro Single submitter ⚠
- p.Leu307Val Single submitter ⚠
- p.Leu308Gln Single submitter ⚠
- p.Leu84Val Single submitter ⚠
- p.Lys26Asn Single submitter ⚠
- p.Lys26Thr Single submitter ⚠
- p.Lys342Arg Single submitter ⚠
- p.Met100Val Single submitter ⚠
- p.Met311Leu Single submitter ⚠
- p.Phe396Leu Single submitter ⚠
- p.Pro250Leu Single submitter ⚠
- p.Pro265Ser Single submitter ⚠
- p.Pro415Leu Single submitter ⚠
- p.Ser173Phe Single submitter ⚠
- p.Ser295Phe Single submitter ⚠
- p.Ser426Trp Single submitter ⚠
- p.Ser43Phe Single submitter ⚠
- p.Thr147Ser Single submitter ⚠
- p.Thr296Ile Single submitter ⚠
- p.Thr310Pro Single submitter ⚠
- p.Thr331Ile Single submitter ⚠
- p.Thr336Ala Single submitter ⚠
- p.Thr60Met Single submitter ⚠
- p.Trp17Arg Single submitter ⚠
- p.Trp456Cys Single submitter ⚠
- p.Tyr263His Single submitter ⚠
- p.Val370Met Single submitter ⚠
- p.Val429Ala Single submitter ⚠
- p.Val463Ala Single submitter ⚠
- p.Val73Met Single submitter ⚠