CHRNA9 — 78 ClinVar variants
All ClinVar germline CHRNA9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 74 flagged for review →
6 Likely benign · 72 Uncertain significance
Full CHRNA9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 74
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHRNA9 p.Arg138Pro Uncertain significance Single submitter
- CHRNA9 p.Arg19Thr Uncertain significance Single submitter
- CHRNA9 p.Arg235Lys Uncertain significance Single submitter
- CHRNA9 p.Arg236Lys Uncertain significance Single submitter
- CHRNA9 p.Arg365Gly Uncertain significance Single submitter
- CHRNA9 p.Arg367Gln Uncertain significance Single submitter
- CHRNA9 p.Arg457Gln Uncertain significance Single submitter
- CHRNA9 p.Asn134Asp Uncertain significance Single submitter
- CHRNA9 p.Asn181Lys Uncertain significance Single submitter
- CHRNA9 p.Asn213His Uncertain significance Single submitter
- CHRNA9 p.Asn243Ile Uncertain significance Single submitter
- CHRNA9 p.Asn397Ser Uncertain significance Single submitter
- CHRNA9 p.Asp116Gly Uncertain significance Single submitter
- CHRNA9 p.Asp193Val Uncertain significance Single submitter
- CHRNA9 p.Asp389Glu Uncertain significance Single submitter
- CHRNA9 p.Cys169Arg Uncertain significance Single submitter
- CHRNA9 p.Cys248Arg Uncertain significance Single submitter
- CHRNA9 p.Cys248Phe Uncertain significance Single submitter
- CHRNA9 p.Cys418Arg Uncertain significance Single submitter
- CHRNA9 p.Cys418Gly Uncertain significance Single submitter
- CHRNA9 p.Glu366Gln Uncertain significance Single submitter
- CHRNA9 p.Gly141Glu Uncertain significance Single submitter
- CHRNA9 p.Gly192Arg Uncertain significance Single submitter
- CHRNA9 p.Gly405Asp Uncertain significance Single submitter
- CHRNA9 p.His438Arg Uncertain significance Single submitter
- CHRNA9 p.Ile107Asn Uncertain significance Single submitter
- CHRNA9 p.Ile198Thr Uncertain significance Single submitter
- CHRNA9 p.Ile472Met Uncertain significance Single submitter
- CHRNA9 p.Ile8Phe Uncertain significance Single submitter
- CHRNA9 p.Leu171Arg Uncertain significance Single submitter
- CHRNA9 p.Leu244Pro Uncertain significance Single submitter
- CHRNA9 p.Leu56Pro Uncertain significance Single submitter
- CHRNA9 p.Leu81Val Uncertain significance Single submitter
- CHRNA9 p.Lys372Glu Uncertain significance Single submitter
- CHRNA9 p.Lys433Arg Uncertain significance Single submitter
- CHRNA9 p.Met319Ile Uncertain significance Single submitter
- CHRNA9 p.Pro148Ser Uncertain significance Single submitter
- CHRNA9 p.Pro297Leu Uncertain significance Single submitter
- CHRNA9 p.Pro334Ser Uncertain significance Single submitter
- CHRNA9 p.Pro361Leu Uncertain significance Single submitter
- CHRNA9 p.Ser258Gly Uncertain significance Single submitter
- CHRNA9 p.Ser313Pro Uncertain significance Single submitter
- CHRNA9 p.Ser346Phe Uncertain significance Single submitter
- CHRNA9 p.Ser65Phe Uncertain significance Single submitter
- CHRNA9 p.Thr371Met Uncertain significance Single submitter
- CHRNA9 p.Thr425Met Uncertain significance Single submitter
- CHRNA9 p.Tyr120His Uncertain significance Single submitter
- CHRNA9 p.Tyr217Cys Uncertain significance Single submitter
- CHRNA9 p.Val112Leu Uncertain significance Single submitter
- CHRNA9 p.Val156Leu Uncertain significance Single submitter
- CHRNA9 p.Val156Met Uncertain significance Single submitter
- CHRNA9 p.Val467Glu Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- CHRNA9 p.Ala22Asp Uncertain significance Single submitter
- CHRNA9 p.Ala263Pro Uncertain significance Single submitter
- CHRNA9 p.Ala305Thr Uncertain significance Single submitter
- CHRNA9 p.Ala31Thr Uncertain significance Single submitter
- CHRNA9 p.Arg138Gln Uncertain significance Single submitter
- CHRNA9 p.Arg138Trp Uncertain significance Single submitter
- CHRNA9 p.Asp100His Uncertain significance Single submitter
- CHRNA9 p.Asp125Val Uncertain significance Single submitter
- CHRNA9 p.Glu329Lys Uncertain significance Single submitter
- CHRNA9 p.Gly101Ser Uncertain significance Single submitter
- CHRNA9 p.Ile105Val Uncertain significance Single submitter
- CHRNA9 p.Ile475Thr Uncertain significance Single submitter
- CHRNA9 p.Ile8Thr Uncertain significance Single submitter
- CHRNA9 p.Leu473Trp Likely benign Single submitter
- CHRNA9 p.Lys33Asn Likely benign Single submitter
- CHRNA9 p.Met319Thr Uncertain significance Single submitter
- CHRNA9 p.Phe39Leu Uncertain significance Single submitter
- CHRNA9 p.Ser109Thr Uncertain significance Single submitter
- CHRNA9 p.Thr151Ile Uncertain significance Single submitter
- CHRNA9 p.Thr63Met Uncertain significance Single submitter
- CHRNA9 p.Val281Ile Uncertain significance Single submitter
- CHRNA9 p.Val467Ala Uncertain significance Single submitter
All CHRNA9 variants
Likely benign 6
- p.Ile472Val Single submitter
- p.Leu473Trp Single submitter ⚠
- p.Lys33Asn Single submitter ⚠
- p.Pro225= Single submitter
- p.Ser391Pro Single submitter
- p.Thr78= Single submitter
Uncertain significance 72
- p.Ala22Asp Single submitter ⚠
- p.Ala263Pro Single submitter ⚠
- p.Ala305Thr Single submitter ⚠
- p.Ala31Thr Single submitter ⚠
- p.Arg138Gln Single submitter ⚠
- p.Arg138Pro Single submitter ⚠
- p.Arg138Trp Single submitter ⚠
- p.Arg19Thr Single submitter ⚠
- p.Arg235Lys Single submitter ⚠
- p.Arg236Lys Single submitter ⚠
- p.Arg365Gly Single submitter ⚠
- p.Arg367Gln Single submitter ⚠
- p.Arg457Gln Single submitter ⚠
- p.Asn134Asp Single submitter ⚠
- p.Asn181Lys Single submitter ⚠
- p.Asn213His Single submitter ⚠
- p.Asn243Ile Single submitter ⚠
- p.Asn397Ser Single submitter ⚠
- p.Asp100His Single submitter ⚠
- p.Asp116Gly Single submitter ⚠
- p.Asp125Val Single submitter ⚠
- p.Asp193Val Single submitter ⚠
- p.Asp389Glu Single submitter ⚠
- p.Cys169Arg Single submitter ⚠
- p.Cys248Arg Single submitter ⚠
- p.Cys248Phe Single submitter ⚠
- p.Cys418Arg Single submitter ⚠
- p.Cys418Gly Single submitter ⚠
- p.Glu329Lys Single submitter ⚠
- p.Glu366Gln Single submitter ⚠
- p.Gly101Ser Single submitter ⚠
- p.Gly141Glu Single submitter ⚠
- p.Gly192Arg Single submitter ⚠
- p.Gly405Asp Single submitter ⚠
- p.His438Arg Single submitter ⚠
- p.Ile105Val Single submitter ⚠
- p.Ile107Asn Single submitter ⚠
- p.Ile198Thr Single submitter ⚠
- p.Ile472Met Single submitter ⚠
- p.Ile475Thr Single submitter ⚠
- p.Ile8Phe Single submitter ⚠
- p.Ile8Thr Single submitter ⚠
- p.Leu171Arg Single submitter ⚠
- p.Leu244Pro Single submitter ⚠
- p.Leu56Pro Single submitter ⚠
- p.Leu81Val Single submitter ⚠
- p.Lys372Glu Single submitter ⚠
- p.Lys433Arg Single submitter ⚠
- p.Met319Ile Single submitter ⚠
- p.Met319Thr Single submitter ⚠
- p.Phe39Leu Single submitter ⚠
- p.Pro148Ser Single submitter ⚠
- p.Pro297Leu Single submitter ⚠
- p.Pro334Ser Single submitter ⚠
- p.Pro361Leu Single submitter ⚠
- p.Ser109Thr Single submitter ⚠
- p.Ser258Gly Single submitter ⚠
- p.Ser313Pro Single submitter ⚠
- p.Ser346Phe Single submitter ⚠
- p.Ser65Phe Single submitter ⚠
- p.Thr151Ile Single submitter ⚠
- p.Thr371Met Single submitter ⚠
- p.Thr425Met Single submitter ⚠
- p.Thr63Met Single submitter ⚠
- p.Tyr120His Single submitter ⚠
- p.Tyr217Cys Single submitter ⚠
- p.Val112Leu Single submitter ⚠
- p.Val156Leu Single submitter ⚠
- p.Val156Met Single submitter ⚠
- p.Val281Ile Single submitter ⚠
- p.Val467Ala Single submitter ⚠
- p.Val467Glu Single submitter ⚠