CHRNB3 — 71 ClinVar variants
All ClinVar germline CHRNB3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
2 Benign · 2 Likely benign · 67 Uncertain significance
Full CHRNB3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHRNB3 p.Ala18Val Uncertain significance Single submitter
- CHRNB3 p.Ala206Thr Uncertain significance Single submitter
- CHRNB3 p.Ala396Ser Uncertain significance Single submitter
- CHRNB3 p.Arg231Cys Uncertain significance Single submitter
- CHRNB3 p.Arg231Ser Uncertain significance Single submitter
- CHRNB3 p.Arg45His Uncertain significance Single submitter
- CHRNB3 p.Arg45Leu Uncertain significance Single submitter
- CHRNB3 p.Asn28Asp Uncertain significance Single submitter
- CHRNB3 p.Asn72Thr Uncertain significance Single submitter
- CHRNB3 p.Asp191Tyr Uncertain significance Single submitter
- CHRNB3 p.Cys167Arg Uncertain significance Single submitter
- CHRNB3 p.Gly123Arg Uncertain significance Single submitter
- CHRNB3 p.Gly127Val Uncertain significance Single submitter
- CHRNB3 p.Gly139Arg Uncertain significance Single submitter
- CHRNB3 p.Gly139Glu Uncertain significance Single submitter
- CHRNB3 p.Ile303Val Uncertain significance Single submitter
- CHRNB3 p.Ile62Thr Uncertain significance Single submitter
- CHRNB3 p.Leu234Phe Uncertain significance Single submitter
- CHRNB3 p.Leu245Pro Uncertain significance Single submitter
- CHRNB3 p.Leu279Arg Uncertain significance Single submitter
- CHRNB3 p.Leu431Pro Uncertain significance Single submitter
- CHRNB3 p.Lys264Asn Uncertain significance Single submitter
- CHRNB3 p.Lys375Arg Uncertain significance Single submitter
- CHRNB3 p.Lys376Gln Uncertain significance Single submitter
- CHRNB3 p.Lys89Glu Uncertain significance Single submitter
- CHRNB3 p.Met130Ile Uncertain significance Single submitter
- CHRNB3 p.Met155Arg Uncertain significance Single submitter
- CHRNB3 p.Met452Lys Uncertain significance Single submitter
- CHRNB3 p.Phe159Leu Uncertain significance Single submitter
- CHRNB3 p.Ser270Leu Uncertain significance Single submitter
- CHRNB3 p.Ser358Pro Uncertain significance Single submitter
- CHRNB3 p.Thr140Ser Uncertain significance Single submitter
- CHRNB3 p.Thr154Pro Uncertain significance Single submitter
- CHRNB3 p.Tyr225Cys Uncertain significance Single submitter
- CHRNB3 p.Tyr57His Uncertain significance Single submitter
- CHRNB3 p.Val105Ala Uncertain significance Single submitter
- CHRNB3 p.Val105Ile Uncertain significance Single submitter
- CHRNB3 p.Val105Phe Uncertain significance Single submitter
- CHRNB3 p.Val116Ala Uncertain significance Single submitter
- CHRNB3 p.Val133Asp Uncertain significance Single submitter
- CHRNB3 p.Val228Leu Uncertain significance Single submitter
- CHRNB3 p.Val271Ile Uncertain significance Single submitter
- CHRNB3 p.Val315Ala Uncertain significance Single submitter
- CHRNB3 p.Val315Met Uncertain significance Single submitter
- CHRNB3 p.Val368Glu Uncertain significance Single submitter
- CHRNB3 p.Val68Met Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- CHRNB3 p.Lys451Glu Benign Multiple submitters
- CHRNB3 p.Ala147Val Uncertain significance Single submitter
- CHRNB3 p.Ala26Thr Uncertain significance Single submitter
- CHRNB3 p.Ala31Asp Uncertain significance Single submitter
- CHRNB3 p.Arg213Gly Uncertain significance Single submitter
- CHRNB3 p.Arg91Cys Uncertain significance Single submitter
- CHRNB3 p.Arg91His Uncertain significance Single submitter
- CHRNB3 p.Gly99Arg Uncertain significance Single submitter
- CHRNB3 p.Ile436Met Uncertain significance Single submitter
- CHRNB3 p.Met349Val Uncertain significance Single submitter
- CHRNB3 p.Ser219Ala Uncertain significance Single submitter
- CHRNB3 p.Ser219Pro Uncertain significance Single submitter
- CHRNB3 p.Ser24Pro Uncertain significance Single submitter
- CHRNB3 p.Ser270Thr Uncertain significance Single submitter
- CHRNB3 p.Ser382Arg Uncertain significance Single submitter
- CHRNB3 p.Ser442Ala Uncertain significance Single submitter
- CHRNB3 p.Thr327Met Uncertain significance Single submitter
- CHRNB3 p.Tyr256Ser Uncertain significance Single submitter
- CHRNB3 p.Tyr401His Uncertain significance Single submitter
- CHRNB3 p.Val141Ala Uncertain significance Single submitter
- CHRNB3 p.Val157Ile Uncertain significance Single submitter
- CHRNB3 p.Val406Ala Uncertain significance Single submitter
All CHRNB3 variants
Benign 2
- p.Ile25= Multiple submitters
- p.Lys451Glu Multiple submitters ⚠
Likely benign 2
- p.His455Arg Single submitter
- p.Val367Ala Single submitter
Uncertain significance 67
- p.Ala147Val Single submitter ⚠
- p.Ala18Val Single submitter ⚠
- p.Ala206Thr Single submitter ⚠
- p.Ala26Thr Single submitter ⚠
- p.Ala31Asp Single submitter ⚠
- p.Ala396Ser Single submitter ⚠
- p.Arg213Gly Single submitter ⚠
- p.Arg231Cys Single submitter ⚠
- p.Arg231Ser Single submitter ⚠
- p.Arg45His Single submitter ⚠
- p.Arg45Leu Single submitter ⚠
- p.Arg91Cys Single submitter ⚠
- p.Arg91His Single submitter ⚠
- p.Asn28Asp Single submitter ⚠
- p.Asn72Thr Single submitter ⚠
- p.Asp191Tyr Single submitter ⚠
- p.Cys167Arg Single submitter ⚠
- p.Gly123Arg Single submitter ⚠
- p.Gly127Val Single submitter ⚠
- p.Gly139Arg Single submitter ⚠
- p.Gly139Glu Single submitter ⚠
- p.Gly99Arg Single submitter ⚠
- p.Ile303Val Single submitter ⚠
- p.Ile436Met Single submitter ⚠
- p.Ile62Thr Single submitter ⚠
- p.Leu234Phe Single submitter ⚠
- p.Leu245Pro Single submitter ⚠
- p.Leu279Arg Single submitter ⚠
- p.Leu431Pro Single submitter ⚠
- p.Lys264Asn Single submitter ⚠
- p.Lys375Arg Single submitter ⚠
- p.Lys376Gln Single submitter ⚠
- p.Lys89Glu Single submitter ⚠
- p.Met130Ile Single submitter ⚠
- p.Met155Arg Single submitter ⚠
- p.Met349Val Single submitter ⚠
- p.Met452Lys Single submitter ⚠
- p.Phe159Leu Single submitter ⚠
- p.Ser219Ala Single submitter ⚠
- p.Ser219Pro Single submitter ⚠
- p.Ser24Pro Single submitter ⚠
- p.Ser270Leu Single submitter ⚠
- p.Ser270Thr Single submitter ⚠
- p.Ser358Pro Single submitter ⚠
- p.Ser382Arg Single submitter ⚠
- p.Ser442Ala Single submitter ⚠
- p.Thr140Ser Single submitter ⚠
- p.Thr154Pro Single submitter ⚠
- p.Thr327Met Single submitter ⚠
- p.Tyr225Cys Single submitter ⚠
- p.Tyr256Ser Single submitter ⚠
- p.Tyr401His Single submitter ⚠
- p.Tyr57His Single submitter ⚠
- p.Val105Ala Single submitter ⚠
- p.Val105Ile Single submitter ⚠
- p.Val105Phe Single submitter ⚠
- p.Val116Ala Single submitter ⚠
- p.Val133Asp Single submitter ⚠
- p.Val141Ala Single submitter ⚠
- p.Val157Ile Single submitter ⚠
- p.Val228Leu Single submitter ⚠
- p.Val271Ile Single submitter ⚠
- p.Val315Ala Single submitter ⚠
- p.Val315Met Single submitter ⚠
- p.Val368Glu Single submitter ⚠
- p.Val406Ala Single submitter ⚠
- p.Val68Met Single submitter ⚠