CHST1 — 37 ClinVar variants
All ClinVar germline CHST1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
1 Likely benign · 36 Uncertain significance
Full CHST1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHST1 p.Arg59His Uncertain significance Multiple submitters
- CHST1 p.Ala12Thr Uncertain significance Single submitter
- CHST1 p.Ala43Val Uncertain significance Single submitter
- CHST1 p.Ala54Thr Uncertain significance Single submitter
- CHST1 p.Arg114Gln Uncertain significance Single submitter
- CHST1 p.Arg198Ser Uncertain significance Single submitter
- CHST1 p.Arg301Cys Uncertain significance Single submitter
- CHST1 p.Arg330His Uncertain significance Single submitter
- CHST1 p.Arg363Ser Uncertain significance Single submitter
- CHST1 p.Arg408Gly Uncertain significance Single submitter
- CHST1 p.Arg70Leu Uncertain significance Single submitter
- CHST1 p.Asn214Asp Uncertain significance Single submitter
- CHST1 p.Asn214Ser Uncertain significance Single submitter
- CHST1 p.Asp167His Uncertain significance Single submitter
- CHST1 p.Gln2Glu Uncertain significance Single submitter
- CHST1 p.Gln333Glu Uncertain significance Single submitter
- CHST1 p.Glu136Gly Uncertain significance Single submitter
- CHST1 p.Gly41Arg Uncertain significance Single submitter
- CHST1 p.Leu320Val Uncertain significance Single submitter
- CHST1 p.Leu42Pro Uncertain significance Single submitter
- CHST1 p.Leu57Ile Uncertain significance Single submitter
- CHST1 p.Lys108Arg Uncertain significance Single submitter
- CHST1 p.Lys140Arg Uncertain significance Single submitter
- CHST1 p.Pro51Leu Uncertain significance Single submitter
- CHST1 p.Thr274Met Uncertain significance Single submitter
- CHST1 p.Thr33Ala Uncertain significance Single submitter
- CHST1 p.Val210Met Uncertain significance Single submitter
- CHST1 p.Val233Phe Uncertain significance Single submitter
- CHST1 p.Val350Leu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CHST1 p.Ala388Thr Uncertain significance Single submitter
- CHST1 p.Arg217His Uncertain significance Single submitter
- CHST1 p.Asn396Ser Uncertain significance Single submitter
- CHST1 p.Pro102Ser Uncertain significance Single submitter
- CHST1 p.Pro223Arg Uncertain significance Single submitter
- CHST1 p.Thr61Ile Uncertain significance Single submitter
- CHST1 p.Val203Leu Uncertain significance Single submitter
All CHST1 variants
Likely benign 1
- p.Gln378Arg Single submitter
Uncertain significance 36
- p.Arg59His Multiple submitters ⚠
- p.Ala12Thr Single submitter ⚠
- p.Ala388Thr Single submitter ⚠
- p.Ala43Val Single submitter ⚠
- p.Ala54Thr Single submitter ⚠
- p.Arg114Gln Single submitter ⚠
- p.Arg198Ser Single submitter ⚠
- p.Arg217His Single submitter ⚠
- p.Arg301Cys Single submitter ⚠
- p.Arg330His Single submitter ⚠
- p.Arg363Ser Single submitter ⚠
- p.Arg408Gly Single submitter ⚠
- p.Arg70Leu Single submitter ⚠
- p.Asn214Asp Single submitter ⚠
- p.Asn214Ser Single submitter ⚠
- p.Asn396Ser Single submitter ⚠
- p.Asp167His Single submitter ⚠
- p.Gln2Glu Single submitter ⚠
- p.Gln333Glu Single submitter ⚠
- p.Glu136Gly Single submitter ⚠
- p.Gly41Arg Single submitter ⚠
- p.Leu320Val Single submitter ⚠
- p.Leu42Pro Single submitter ⚠
- p.Leu57Ile Single submitter ⚠
- p.Lys108Arg Single submitter ⚠
- p.Lys140Arg Single submitter ⚠
- p.Pro102Ser Single submitter ⚠
- p.Pro223Arg Single submitter ⚠
- p.Pro51Leu Single submitter ⚠
- p.Thr274Met Single submitter ⚠
- p.Thr33Ala Single submitter ⚠
- p.Thr61Ile Single submitter ⚠
- p.Val203Leu Single submitter ⚠
- p.Val210Met Single submitter ⚠
- p.Val233Phe Single submitter ⚠
- p.Val350Leu Single submitter ⚠