CHST10 — 48 ClinVar variants
All ClinVar germline CHST10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
1 Likely benign · 47 Uncertain significance
Full CHST10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHST10 p.Arg229Trp Uncertain significance Single submitter
- CHST10 p.Arg242Cys Uncertain significance Single submitter
- CHST10 p.Arg330Gln Uncertain significance Single submitter
- CHST10 p.Arg333Gln Uncertain significance Single submitter
- CHST10 p.Arg84Leu Uncertain significance Single submitter
- CHST10 p.Asn142Lys Uncertain significance Single submitter
- CHST10 p.Asn228Ser Uncertain significance Single submitter
- CHST10 p.Asn90Lys Uncertain significance Single submitter
- CHST10 p.Asp158Asn Uncertain significance Single submitter
- CHST10 p.Asp94Gly Uncertain significance Single submitter
- CHST10 p.Cys124Arg Uncertain significance Single submitter
- CHST10 p.Gln4Arg Uncertain significance Single submitter
- CHST10 p.Gly67Glu Uncertain significance Single submitter
- CHST10 p.Gly67Trp Uncertain significance Single submitter
- CHST10 p.His282Arg Uncertain significance Single submitter
- CHST10 p.Ile196Thr Uncertain significance Single submitter
- CHST10 p.Ile221Thr Uncertain significance Single submitter
- CHST10 p.Ile308Val Uncertain significance Single submitter
- CHST10 p.Leu100Val Uncertain significance Single submitter
- CHST10 p.Met276Thr Uncertain significance Single submitter
- CHST10 p.Phe185Ser Uncertain significance Single submitter
- CHST10 p.Pro104Ser Uncertain significance Single submitter
- CHST10 p.Pro32Ser Uncertain significance Single submitter
- CHST10 p.Pro48Leu Uncertain significance Single submitter
- CHST10 p.Ser171Gly Uncertain significance Single submitter
- CHST10 p.Ser304Pro Uncertain significance Single submitter
- CHST10 p.Ser36Gly Uncertain significance Single submitter
- CHST10 p.Thr232Ile Uncertain significance Single submitter
- CHST10 p.Thr45Lys Uncertain significance Single submitter
- CHST10 p.Thr66Ala Uncertain significance Single submitter
- CHST10 p.Trp251Arg Uncertain significance Single submitter
- CHST10 p.Val137Gly Uncertain significance Single submitter
- CHST10 p.Val155Met Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- CHST10 p.Arg166Trp Uncertain significance Single submitter
- CHST10 p.Arg208Leu Uncertain significance Single submitter
- CHST10 p.Arg208Trp Uncertain significance Single submitter
- CHST10 p.Asp190His Uncertain significance Single submitter
- CHST10 p.Glu153Lys Uncertain significance Single submitter
- CHST10 p.Gly245Ser Uncertain significance Single submitter
- CHST10 p.His301Leu Uncertain significance Single submitter
- CHST10 p.His301Tyr Uncertain significance Single submitter
- CHST10 p.Ile221Val Uncertain significance Single submitter
- CHST10 p.Lys23Thr Uncertain significance Single submitter
- CHST10 p.Phe186Tyr Uncertain significance Single submitter
- CHST10 p.Val303Ala Uncertain significance Single submitter
- CHST10 p.Lys161Asn Uncertain significance No assertion criteria
All CHST10 variants
Likely benign 1
- p.Lys98Arg Single submitter
Uncertain significance 47
- p.Arg166Trp Single submitter ⚠
- p.Arg208Leu Single submitter ⚠
- p.Arg208Trp Single submitter ⚠
- p.Arg229Trp Single submitter ⚠
- p.Arg242Cys Single submitter ⚠
- p.Arg330Gln Single submitter ⚠
- p.Arg333Gln Single submitter ⚠
- p.Arg84Leu Single submitter ⚠
- p.Asn142Lys Single submitter ⚠
- p.Asn228Ser Single submitter ⚠
- p.Asn90Lys Single submitter ⚠
- p.Asp158Asn Single submitter ⚠
- p.Asp190His Single submitter ⚠
- p.Asp94Gly Single submitter ⚠
- p.Cys124Arg Single submitter ⚠
- p.Gln4Arg Single submitter ⚠
- p.Glu153Lys Single submitter ⚠
- p.Gly245Ser Single submitter ⚠
- p.Gly67Glu Single submitter ⚠
- p.Gly67Trp Single submitter ⚠
- p.His282Arg Single submitter ⚠
- p.His301Leu Single submitter ⚠
- p.His301Tyr Single submitter ⚠
- p.Ile196Thr Single submitter ⚠
- p.Ile221Thr Single submitter ⚠
- p.Ile221Val Single submitter ⚠
- p.Ile308Val Single submitter ⚠
- p.Ile88Thr Single submitter
- p.Leu100Val Single submitter ⚠
- p.Lys23Thr Single submitter ⚠
- p.Met276Thr Single submitter ⚠
- p.Phe185Ser Single submitter ⚠
- p.Phe186Tyr Single submitter ⚠
- p.Pro104Ser Single submitter ⚠
- p.Pro32Ser Single submitter ⚠
- p.Pro48Leu Single submitter ⚠
- p.Ser171Gly Single submitter ⚠
- p.Ser304Pro Single submitter ⚠
- p.Ser36Gly Single submitter ⚠
- p.Thr232Ile Single submitter ⚠
- p.Thr45Lys Single submitter ⚠
- p.Thr66Ala Single submitter ⚠
- p.Trp251Arg Single submitter ⚠
- p.Val137Gly Single submitter ⚠
- p.Val155Met Single submitter ⚠
- p.Val303Ala Single submitter ⚠
- p.Lys161Asn No assertion criteria ⚠