CHST4 — 77 ClinVar variants
All ClinVar germline CHST4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
10 Likely benign · 67 Uncertain significance
Full CHST4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHST4 p.Ala18Ser Uncertain significance Single submitter
- CHST4 p.Ala18Thr Uncertain significance Single submitter
- CHST4 p.Arg149Trp Uncertain significance Single submitter
- CHST4 p.Arg180Gly Uncertain significance Single submitter
- CHST4 p.Arg205Pro Uncertain significance Single submitter
- CHST4 p.Arg208Trp Uncertain significance Single submitter
- CHST4 p.Arg212His Uncertain significance Single submitter
- CHST4 p.Arg214Leu Uncertain significance Single submitter
- CHST4 p.Arg345Gln Uncertain significance Single submitter
- CHST4 p.Arg52Cys Uncertain significance Single submitter
- CHST4 p.Arg52His Uncertain significance Single submitter
- CHST4 p.Arg95Gly Uncertain significance Single submitter
- CHST4 p.Asp206Asn Uncertain significance Single submitter
- CHST4 p.Asp317Gly Uncertain significance Single submitter
- CHST4 p.Cys133Arg Uncertain significance Single submitter
- CHST4 p.Gln64His Uncertain significance Single submitter
- CHST4 p.Glu233Ala Uncertain significance Single submitter
- CHST4 p.Glu233Lys Uncertain significance Single submitter
- CHST4 p.Gly351Ser Uncertain significance Single submitter
- CHST4 p.His199Tyr Uncertain significance Single submitter
- CHST4 p.Ile227Met Uncertain significance Single submitter
- CHST4 p.Lys265Arg Uncertain significance Single submitter
- CHST4 p.Met222Thr Uncertain significance Single submitter
- CHST4 p.Phe12Leu Uncertain significance Single submitter
- CHST4 p.Phe211Cys Uncertain significance Single submitter
- CHST4 p.Phe293Leu Uncertain significance Single submitter
- CHST4 p.Ser157Gly Uncertain significance Single submitter
- CHST4 p.Ser225Asn Uncertain significance Single submitter
- CHST4 p.Ser331Tyr Uncertain significance Single submitter
- CHST4 p.Tyr70Cys Uncertain significance Single submitter
- CHST4 p.Val163Leu Uncertain significance Single submitter
- CHST4 p.Val179Ala Uncertain significance Single submitter
- CHST4 p.Val210Glu Uncertain significance Single submitter
- CHST4 p.Val294Met Uncertain significance Single submitter
Predictors split 35
The independent predictors disagree with each other — read with care.
- CHST4 p.Ala135Val Uncertain significance Single submitter
- CHST4 p.Ala167Ser Uncertain significance Single submitter
- CHST4 p.Ala333Val Uncertain significance Single submitter
- CHST4 p.Arg118Gln Uncertain significance Single submitter
- CHST4 p.Arg130Gln Uncertain significance Single submitter
- CHST4 p.Arg130Trp Uncertain significance Single submitter
- CHST4 p.Arg214Gln Uncertain significance Single submitter
- CHST4 p.Arg216His Likely benign Single submitter
- CHST4 p.Arg216Leu Uncertain significance Single submitter
- CHST4 p.Arg270Cys Uncertain significance Single submitter
- CHST4 p.Arg270His Uncertain significance Single submitter
- CHST4 p.Arg289Leu Uncertain significance Single submitter
- CHST4 p.Arg42Gly Uncertain significance Single submitter
- CHST4 p.Arg99Trp Uncertain significance Single submitter
- CHST4 p.Asn370Lys Uncertain significance Single submitter
- CHST4 p.Gln16Arg Uncertain significance Single submitter
- CHST4 p.Glu292Val Uncertain significance Single submitter
- CHST4 p.Gly314Val Uncertain significance Single submitter
- CHST4 p.Gly358Ala Uncertain significance Single submitter
- CHST4 p.Gly358Ser Uncertain significance Single submitter
- CHST4 p.Leu123Val Uncertain significance Single submitter
- CHST4 p.Leu221Ile Uncertain significance Single submitter
- CHST4 p.Leu22Pro Uncertain significance Single submitter
- CHST4 p.Leu272Val Uncertain significance Single submitter
- CHST4 p.Leu375Ile Uncertain significance Single submitter
- CHST4 p.Met106Val Uncertain significance Single submitter
- CHST4 p.Met72Arg Uncertain significance Single submitter
- CHST4 p.Phe23Tyr Uncertain significance Single submitter
- CHST4 p.Pro160Thr Uncertain significance Single submitter
- CHST4 p.Ser157Asn Likely benign Single submitter
- CHST4 p.Ser157Cys Uncertain significance Single submitter
- CHST4 p.Tyr27Ser Uncertain significance Single submitter
- CHST4 p.Val108Ile Uncertain significance Single submitter
- CHST4 p.Val45Met Uncertain significance Single submitter
- CHST4 p.Val78Met Uncertain significance Single submitter
All CHST4 variants
Likely benign 10
- p.Arg149Gln Single submitter
- p.Arg216His Single submitter ⚠
- p.Arg226His Single submitter
- p.Arg360His Single submitter
- p.Arg42His Single submitter
- p.Gln39Glu Single submitter
- p.His25Tyr Single submitter
- p.Ser157Asn Single submitter ⚠
- p.Val101Ile Single submitter
- p.Val47Ile Single submitter
Uncertain significance 67
- p.Ala135Val Single submitter ⚠
- p.Ala167Ser Single submitter ⚠
- p.Ala18Ser Single submitter ⚠
- p.Ala18Thr Single submitter ⚠
- p.Ala333Val Single submitter ⚠
- p.Arg118Gln Single submitter ⚠
- p.Arg130Gln Single submitter ⚠
- p.Arg130Trp Single submitter ⚠
- p.Arg149Trp Single submitter ⚠
- p.Arg180Gly Single submitter ⚠
- p.Arg205Pro Single submitter ⚠
- p.Arg208Trp Single submitter ⚠
- p.Arg212His Single submitter ⚠
- p.Arg214Gln Single submitter ⚠
- p.Arg214Leu Single submitter ⚠
- p.Arg216Leu Single submitter ⚠
- p.Arg270Cys Single submitter ⚠
- p.Arg270His Single submitter ⚠
- p.Arg289Leu Single submitter ⚠
- p.Arg345Gln Single submitter ⚠
- p.Arg42Gly Single submitter ⚠
- p.Arg52Cys Single submitter ⚠
- p.Arg52His Single submitter ⚠
- p.Arg95Gly Single submitter ⚠
- p.Arg99Trp Single submitter ⚠
- p.Asn370Lys Single submitter ⚠
- p.Asp206Asn Single submitter ⚠
- p.Asp317Gly Single submitter ⚠
- p.Cys133Arg Single submitter ⚠
- p.Gln16Arg Single submitter ⚠
- p.Gln64His Single submitter ⚠
- p.Glu233Ala Single submitter ⚠
- p.Glu233Lys Single submitter ⚠
- p.Glu292Val Single submitter ⚠
- p.Gly314Val Single submitter ⚠
- p.Gly351Ser Single submitter ⚠
- p.Gly358Ala Single submitter ⚠
- p.Gly358Ser Single submitter ⚠
- p.His199Tyr Single submitter ⚠
- p.Ile227Met Single submitter ⚠
- p.Leu123Val Single submitter ⚠
- p.Leu221Ile Single submitter ⚠
- p.Leu22Pro Single submitter ⚠
- p.Leu272Val Single submitter ⚠
- p.Leu375Ile Single submitter ⚠
- p.Lys265Arg Single submitter ⚠
- p.Met106Val Single submitter ⚠
- p.Met222Thr Single submitter ⚠
- p.Met72Arg Single submitter ⚠
- p.Phe12Leu Single submitter ⚠
- p.Phe211Cys Single submitter ⚠
- p.Phe23Tyr Single submitter ⚠
- p.Phe293Leu Single submitter ⚠
- p.Pro160Thr Single submitter ⚠
- p.Ser157Cys Single submitter ⚠
- p.Ser157Gly Single submitter ⚠
- p.Ser225Asn Single submitter ⚠
- p.Ser331Tyr Single submitter ⚠
- p.Tyr27Ser Single submitter ⚠
- p.Tyr70Cys Single submitter ⚠
- p.Val108Ile Single submitter ⚠
- p.Val163Leu Single submitter ⚠
- p.Val179Ala Single submitter ⚠
- p.Val210Glu Single submitter ⚠
- p.Val294Met Single submitter ⚠
- p.Val45Met Single submitter ⚠
- p.Val78Met Single submitter ⚠