CHST9 — 64 ClinVar variants
All ClinVar germline CHST9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
1 Benign · 4 Likely benign · 59 Uncertain significance
Full CHST9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHST9 p.Ala407Val Uncertain significance Single submitter
- CHST9 p.Arg178Gly Uncertain significance Single submitter
- CHST9 p.Arg411Lys Uncertain significance Single submitter
- CHST9 p.Arg419Lys Uncertain significance Single submitter
- CHST9 p.Arg91Gln Uncertain significance Single submitter
- CHST9 p.Asn9Asp Uncertain significance Single submitter
- CHST9 p.Asp118Glu Uncertain significance Single submitter
- CHST9 p.Asp210Tyr Uncertain significance Single submitter
- CHST9 p.Asp376Asn Uncertain significance Single submitter
- CHST9 p.Gln382Glu Uncertain significance Single submitter
- CHST9 p.Gly138Glu Uncertain significance Single submitter
- CHST9 p.Gly306Arg Uncertain significance Single submitter
- CHST9 p.Gly41Glu Uncertain significance Single submitter
- CHST9 p.His195Arg Uncertain significance Single submitter
- CHST9 p.His201Arg Uncertain significance Single submitter
- CHST9 p.His201Gln Uncertain significance Single submitter
- CHST9 p.Ile155Val Uncertain significance Single submitter
- CHST9 p.Ile35Met Uncertain significance Single submitter
- CHST9 p.Lys164Arg Uncertain significance Single submitter
- CHST9 p.Lys164Asn Uncertain significance Single submitter
- CHST9 p.Lys170Thr Uncertain significance Single submitter
- CHST9 p.Lys264Asn Uncertain significance Single submitter
- CHST9 p.Lys355Thr Uncertain significance Single submitter
- CHST9 p.Lys369Glu Uncertain significance Single submitter
- CHST9 p.Lys72Arg Uncertain significance Single submitter
- CHST9 p.Met149Ile Uncertain significance Single submitter
- CHST9 p.Met232Thr Uncertain significance Single submitter
- CHST9 p.Met283Lys Uncertain significance Single submitter
- CHST9 p.Met383Ile Uncertain significance Single submitter
- CHST9 p.Met8Val Uncertain significance Single submitter
- CHST9 p.Phe181Leu Uncertain significance Single submitter
- CHST9 p.Phe442Leu Uncertain significance Single submitter
- CHST9 p.Pro282Thr Uncertain significance Single submitter
- CHST9 p.Pro359Leu Uncertain significance Single submitter
- CHST9 p.Pro57Leu Uncertain significance Single submitter
- CHST9 p.Ser112Arg Uncertain significance Single submitter
- CHST9 p.Ser53Leu Uncertain significance Single submitter
- CHST9 p.Thr105Ala Uncertain significance Single submitter
- CHST9 p.Thr70Ala Uncertain significance Single submitter
- CHST9 p.Trp151Arg Uncertain significance Single submitter
- CHST9 p.Tyr216His Uncertain significance Single submitter
- CHST9 p.Val17Gly Uncertain significance Single submitter
- CHST9 p.Val192Ala Uncertain significance Single submitter
- CHST9 p.Val192Leu Uncertain significance Single submitter
- CHST9 p.Val64Ile Uncertain significance Single submitter
- CHST9 p.Val7Phe Uncertain significance Single submitter
- CHST9 p.Val90Ile Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- CHST9 p.Ala276Ser Uncertain significance Single submitter
- CHST9 p.Arg314Gln Uncertain significance Single submitter
- CHST9 p.Arg342Cys Uncertain significance Single submitter
- CHST9 p.Arg62Trp Uncertain significance Single submitter
- CHST9 p.Asp262Asn Uncertain significance Single submitter
- CHST9 p.Gly252Arg Uncertain significance Single submitter
- CHST9 p.Gly385Ser Uncertain significance Single submitter
- CHST9 p.Ile244Val Uncertain significance Single submitter
- CHST9 p.Lys170Ile Uncertain significance Single submitter
- CHST9 p.Met383Lys Uncertain significance Single submitter
- CHST9 p.Pro297Thr Uncertain significance Single submitter
- CHST9 p.Ser354Cys Uncertain significance Single submitter
All CHST9 variants
Benign 1
- p.Pro393= Multiple submitters
Likely benign 4
- p.Arg62Gln Single submitter
- p.Asp259= Single submitter
- p.Gly190Ser Single submitter
- p.Val203= Single submitter
Uncertain significance 59
- p.Ala276Ser Single submitter ⚠
- p.Ala407Val Single submitter ⚠
- p.Arg178Gly Single submitter ⚠
- p.Arg314Gln Single submitter ⚠
- p.Arg342Cys Single submitter ⚠
- p.Arg411Lys Single submitter ⚠
- p.Arg419Lys Single submitter ⚠
- p.Arg62Trp Single submitter ⚠
- p.Arg91Gln Single submitter ⚠
- p.Asn9Asp Single submitter ⚠
- p.Asp118Glu Single submitter ⚠
- p.Asp210Tyr Single submitter ⚠
- p.Asp262Asn Single submitter ⚠
- p.Asp376Asn Single submitter ⚠
- p.Gln382Glu Single submitter ⚠
- p.Gly138Glu Single submitter ⚠
- p.Gly252Arg Single submitter ⚠
- p.Gly306Arg Single submitter ⚠
- p.Gly385Ser Single submitter ⚠
- p.Gly41Glu Single submitter ⚠
- p.His195Arg Single submitter ⚠
- p.His201Arg Single submitter ⚠
- p.His201Gln Single submitter ⚠
- p.Ile155Val Single submitter ⚠
- p.Ile244Val Single submitter ⚠
- p.Ile35Met Single submitter ⚠
- p.Lys164Arg Single submitter ⚠
- p.Lys164Asn Single submitter ⚠
- p.Lys170Ile Single submitter ⚠
- p.Lys170Thr Single submitter ⚠
- p.Lys264Asn Single submitter ⚠
- p.Lys355Thr Single submitter ⚠
- p.Lys369Glu Single submitter ⚠
- p.Lys72Arg Single submitter ⚠
- p.Met149Ile Single submitter ⚠
- p.Met232Thr Single submitter ⚠
- p.Met283Lys Single submitter ⚠
- p.Met383Ile Single submitter ⚠
- p.Met383Lys Single submitter ⚠
- p.Met8Val Single submitter ⚠
- p.Phe181Leu Single submitter ⚠
- p.Phe442Leu Single submitter ⚠
- p.Pro282Thr Single submitter ⚠
- p.Pro297Thr Single submitter ⚠
- p.Pro359Leu Single submitter ⚠
- p.Pro57Leu Single submitter ⚠
- p.Ser112Arg Single submitter ⚠
- p.Ser354Cys Single submitter ⚠
- p.Ser53Leu Single submitter ⚠
- p.Thr105Ala Single submitter ⚠
- p.Thr70Ala Single submitter ⚠
- p.Trp151Arg Single submitter ⚠
- p.Tyr216His Single submitter ⚠
- p.Val17Gly Single submitter ⚠
- p.Val192Ala Single submitter ⚠
- p.Val192Leu Single submitter ⚠
- p.Val64Ile Single submitter ⚠
- p.Val7Phe Single submitter ⚠
- p.Val90Ile Single submitter ⚠