Sugi Variant

Sugi Variant/CHUK

CHUK — 266 ClinVar variants

All ClinVar germline CHUK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 95 flagged for review →

4 Pathogenic · 2 Likely pathogenic · 1 Conflicting · 38 Benign · 3 Benign/Likely benign · 120 Likely benign · 98 Uncertain significance

Full CHUK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 95

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 61

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 34

The independent predictors disagree with each other — read with care.

All CHUK variants

Pathogenic 4

Likely pathogenic 2

Conflicting classifications of pathogenicity 1

Benign 38

Benign/Likely benign 3

Likely benign 120

Uncertain significance 98