CIAPIN1 — 34 ClinVar variants
All ClinVar germline CIAPIN1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
3 Likely benign · 31 Uncertain significance
Full CIAPIN1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CIAPIN1 p.Ala102Thr Uncertain significance Single submitter
- CIAPIN1 p.Ala112Thr Uncertain significance Single submitter
- CIAPIN1 p.Arg132Gln Uncertain significance Single submitter
- CIAPIN1 p.Arg284Cys Uncertain significance Single submitter
- CIAPIN1 p.Arg284His Uncertain significance Single submitter
- CIAPIN1 p.Asn105Asp Uncertain significance Single submitter
- CIAPIN1 p.Cys246Ser Uncertain significance Single submitter
- CIAPIN1 p.Glu138Gln Uncertain significance Single submitter
- CIAPIN1 p.Glu206Ala Uncertain significance Single submitter
- CIAPIN1 p.Glu217Gln Uncertain significance Single submitter
- CIAPIN1 p.Glu255Lys Uncertain significance Single submitter
- CIAPIN1 p.Glu256Gln Uncertain significance Single submitter
- CIAPIN1 p.Glu78Ala Uncertain significance Single submitter
- CIAPIN1 p.Ile47Thr Uncertain significance Single submitter
- CIAPIN1 p.Leu253Pro Uncertain significance Single submitter
- CIAPIN1 p.Met293Ile Uncertain significance Single submitter
- CIAPIN1 p.Phe296Leu Uncertain significance Single submitter
- CIAPIN1 p.Pro294Gln Uncertain significance Single submitter
- CIAPIN1 p.Ser117Leu Uncertain significance Single submitter
- CIAPIN1 p.Ser177Pro Uncertain significance Single submitter
- CIAPIN1 p.Ser215Pro Uncertain significance Single submitter
- CIAPIN1 p.Ser287Gly Uncertain significance Single submitter
- CIAPIN1 p.Ser59Thr Uncertain significance Single submitter
- CIAPIN1 p.Thr36Ile Uncertain significance Single submitter
- CIAPIN1 p.Thr72Ile Uncertain significance Single submitter
- CIAPIN1 p.Tyr278Cys Uncertain significance Single submitter
- CIAPIN1 p.Val143Ile Uncertain significance Single submitter
- CIAPIN1 p.Val15Ala Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All CIAPIN1 variants
Likely benign 3
- p.Asn38Ser Single submitter
- p.Asp3Glu Single submitter
- p.Met210Val Single submitter
Uncertain significance 31
- p.Ala102Thr Single submitter ⚠
- p.Ala112Thr Single submitter ⚠
- p.Arg132Gln Single submitter ⚠
- p.Arg284Cys Single submitter ⚠
- p.Arg284His Single submitter ⚠
- p.Arg85Trp Single submitter ⚠
- p.Asn105Asp Single submitter ⚠
- p.Cys246Ser Single submitter ⚠
- p.Glu138Gln Single submitter ⚠
- p.Glu206Ala Single submitter ⚠
- p.Glu217Gln Single submitter ⚠
- p.Glu255Lys Single submitter ⚠
- p.Glu256Gln Single submitter ⚠
- p.Glu78Ala Single submitter ⚠
- p.Ile47Thr Single submitter ⚠
- p.Leu253Pro Single submitter ⚠
- p.Met293Ile Single submitter ⚠
- p.Phe296Leu Single submitter ⚠
- p.Pro294Gln Single submitter ⚠
- p.Pro298Arg Single submitter ⚠
- p.Ser117Leu Single submitter ⚠
- p.Ser177Pro Single submitter ⚠
- p.Ser215Pro Single submitter ⚠
- p.Ser287Gly Single submitter ⚠
- p.Ser59Thr Single submitter ⚠
- p.Thr36Ile Single submitter ⚠
- p.Thr72Ile Single submitter ⚠
- p.Tyr278Cys Single submitter ⚠
- p.Val143Ile Single submitter ⚠
- p.Val15Ala Single submitter ⚠
- p.Val42Met Single submitter ⚠