CIB3 — 40 ClinVar variants
All ClinVar germline CIB3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
2 Likely benign · 38 Uncertain significance
Full CIB3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CIB3 p.Ala102Pro Uncertain significance Single submitter
- CIB3 p.Ala125Val Uncertain significance Single submitter
- CIB3 p.Ala142Val Uncertain significance Single submitter
- CIB3 p.Arg137Gln Uncertain significance Single submitter
- CIB3 p.Arg186Gly Uncertain significance Single submitter
- CIB3 p.Arg33Cys Uncertain significance Single submitter
- CIB3 p.Arg33Ser Uncertain significance Single submitter
- CIB3 p.Asn119Lys Uncertain significance Single submitter
- CIB3 p.Asp127Asn Uncertain significance Single submitter
- CIB3 p.Gln40Arg Uncertain significance Single submitter
- CIB3 p.Gln72His Uncertain significance Single submitter
- CIB3 p.Glu144Gly Uncertain significance Single submitter
- CIB3 p.Glu64Lys Uncertain significance Single submitter
- CIB3 p.His10Gln Uncertain significance Single submitter
- CIB3 p.Leu147Pro Uncertain significance Single submitter
- CIB3 p.Met86Val Uncertain significance Single submitter
- CIB3 p.Pro55Leu Uncertain significance Single submitter
- CIB3 p.Pro69Ser Uncertain significance Single submitter
- CIB3 p.Ser99Thr Uncertain significance Single submitter
- CIB3 p.Thr131Lys Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- CIB3 p.Ala38Thr Uncertain significance Single submitter
- CIB3 p.Arg104Cys Uncertain significance Single submitter
- CIB3 p.Arg137Trp Uncertain significance Single submitter
- CIB3 p.Arg163Gln Uncertain significance Single submitter
- CIB3 p.Arg163Trp Uncertain significance Single submitter
- CIB3 p.Arg175Gln Uncertain significance Single submitter
- CIB3 p.Arg175Trp Uncertain significance Single submitter
- CIB3 p.Arg71Cys Uncertain significance Single submitter
- CIB3 p.Arg71His Uncertain significance Single submitter
- CIB3 p.Asp45Ala Uncertain significance Single submitter
- CIB3 p.Glu11Lys Uncertain significance Single submitter
- CIB3 p.Gly138Ala Uncertain significance Single submitter
- CIB3 p.Gly138Trp Uncertain significance Single submitter
- CIB3 p.Ile114Val Uncertain significance Single submitter
- CIB3 p.Lys66Gln Uncertain significance Single submitter
- CIB3 p.Thr6Ile Uncertain significance Single submitter
- CIB3 p.Tyr110Cys Uncertain significance Single submitter
- CIB3 p.Tyr32Cys Uncertain significance Single submitter
All CIB3 variants
Likely benign 2
- p.Asn119Asp Single submitter
- p.Leu41= Single submitter
Uncertain significance 38
- p.Ala102Pro Single submitter ⚠
- p.Ala125Val Single submitter ⚠
- p.Ala142Val Single submitter ⚠
- p.Ala38Thr Single submitter ⚠
- p.Arg104Cys Single submitter ⚠
- p.Arg137Gln Single submitter ⚠
- p.Arg137Trp Single submitter ⚠
- p.Arg163Gln Single submitter ⚠
- p.Arg163Trp Single submitter ⚠
- p.Arg175Gln Single submitter ⚠
- p.Arg175Trp Single submitter ⚠
- p.Arg186Gly Single submitter ⚠
- p.Arg33Cys Single submitter ⚠
- p.Arg33Ser Single submitter ⚠
- p.Arg71Cys Single submitter ⚠
- p.Arg71His Single submitter ⚠
- p.Asn119Lys Single submitter ⚠
- p.Asp127Asn Single submitter ⚠
- p.Asp45Ala Single submitter ⚠
- p.Gln40Arg Single submitter ⚠
- p.Gln72His Single submitter ⚠
- p.Glu11Lys Single submitter ⚠
- p.Glu144Gly Single submitter ⚠
- p.Glu64Lys Single submitter ⚠
- p.Gly138Ala Single submitter ⚠
- p.Gly138Trp Single submitter ⚠
- p.His10Gln Single submitter ⚠
- p.Ile114Val Single submitter ⚠
- p.Leu147Pro Single submitter ⚠
- p.Lys66Gln Single submitter ⚠
- p.Met86Val Single submitter ⚠
- p.Pro55Leu Single submitter ⚠
- p.Pro69Ser Single submitter ⚠
- p.Ser99Thr Single submitter ⚠
- p.Thr131Lys Single submitter ⚠
- p.Thr6Ile Single submitter ⚠
- p.Tyr110Cys Single submitter ⚠
- p.Tyr32Cys Single submitter ⚠