CIDEA — 45 ClinVar variants
All ClinVar germline CIDEA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
1 Benign · 1 Likely benign · 43 Uncertain significance
Full CIDEA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CIDEA p.Ala181Asp Uncertain significance Single submitter
- CIDEA p.Ala181Val Uncertain significance Single submitter
- CIDEA p.Arg128Thr Uncertain significance Single submitter
- CIDEA p.Arg175Gln Uncertain significance Single submitter
- CIDEA p.Arg197Gln Uncertain significance Single submitter
- CIDEA p.Arg209Gln Uncertain significance Single submitter
- CIDEA p.Asn41Ser Uncertain significance Single submitter
- CIDEA p.Asp132Asn Uncertain significance Single submitter
- CIDEA p.Gln186Arg Uncertain significance Single submitter
- CIDEA p.Gln211Lys Uncertain significance Single submitter
- CIDEA p.Gly125Arg Uncertain significance Single submitter
- CIDEA p.Gly219Ala Uncertain significance Single submitter
- CIDEA p.Leu102Phe Uncertain significance Single submitter
- CIDEA p.Met151Thr Uncertain significance Single submitter
- CIDEA p.Met154Ile Uncertain significance Single submitter
- CIDEA p.Met154Leu Uncertain significance Single submitter
- CIDEA p.Pro206Leu Uncertain significance Single submitter
- CIDEA p.Pro206Ser Uncertain significance Single submitter
- CIDEA p.Ser178Phe Uncertain significance Single submitter
- CIDEA p.Ser178Pro Uncertain significance Single submitter
- CIDEA p.Tyr134His Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- CIDEA p.Ala127Gly Uncertain significance Single submitter
- CIDEA p.Arg162Trp Uncertain significance Single submitter
- CIDEA p.Arg175Trp Uncertain significance Single submitter
- CIDEA p.Arg197Trp Uncertain significance Single submitter
- CIDEA p.Arg205Trp Uncertain significance Single submitter
- CIDEA p.Arg35His Uncertain significance Single submitter
- CIDEA p.Arg38Trp Uncertain significance Single submitter
- CIDEA p.Asn41Lys Uncertain significance Single submitter
- CIDEA p.Asp160Asn Uncertain significance Single submitter
- CIDEA p.Gln91His Uncertain significance Single submitter
- CIDEA p.Glu88Lys Uncertain significance Single submitter
- CIDEA p.Gly71Arg Uncertain significance Single submitter
- CIDEA p.Gly94Arg Uncertain significance Single submitter
- CIDEA p.His98Arg Uncertain significance Single submitter
- CIDEA p.Leu93Val Benign Single submitter
- CIDEA p.Pro29Leu Uncertain significance Single submitter
- CIDEA p.Ser180Phe Uncertain significance Single submitter
- CIDEA p.Thr150Ala Uncertain significance Single submitter
- CIDEA p.Thr150Asn Uncertain significance Single submitter
- CIDEA p.Thr184Met Uncertain significance Single submitter
- CIDEA p.Thr22Ile Uncertain significance Single submitter
- CIDEA p.Thr97Met Uncertain significance Single submitter
- CIDEA p.Val50Met Uncertain significance Single submitter
All CIDEA variants
Benign 1
- p.Leu93Val Single submitter ⚠
Likely benign 1
- p.Phe27Leu Single submitter
Uncertain significance 43
- p.Ala127Gly Single submitter ⚠
- p.Ala181Asp Single submitter ⚠
- p.Ala181Val Single submitter ⚠
- p.Arg128Thr Single submitter ⚠
- p.Arg162Trp Single submitter ⚠
- p.Arg175Gln Single submitter ⚠
- p.Arg175Trp Single submitter ⚠
- p.Arg197Gln Single submitter ⚠
- p.Arg197Trp Single submitter ⚠
- p.Arg205Trp Single submitter ⚠
- p.Arg209Gln Single submitter ⚠
- p.Arg35His Single submitter ⚠
- p.Arg38Trp Single submitter ⚠
- p.Asn41Lys Single submitter ⚠
- p.Asn41Ser Single submitter ⚠
- p.Asp132Asn Single submitter ⚠
- p.Asp160Asn Single submitter ⚠
- p.Gln186Arg Single submitter ⚠
- p.Gln211Lys Single submitter ⚠
- p.Gln91His Single submitter ⚠
- p.Glu88Lys Single submitter ⚠
- p.Gly125Arg Single submitter ⚠
- p.Gly219Ala Single submitter ⚠
- p.Gly71Arg Single submitter ⚠
- p.Gly94Arg Single submitter ⚠
- p.His98Arg Single submitter ⚠
- p.Leu102Phe Single submitter ⚠
- p.Met151Thr Single submitter ⚠
- p.Met154Ile Single submitter ⚠
- p.Met154Leu Single submitter ⚠
- p.Pro206Leu Single submitter ⚠
- p.Pro206Ser Single submitter ⚠
- p.Pro29Leu Single submitter ⚠
- p.Ser178Phe Single submitter ⚠
- p.Ser178Pro Single submitter ⚠
- p.Ser180Phe Single submitter ⚠
- p.Thr150Ala Single submitter ⚠
- p.Thr150Asn Single submitter ⚠
- p.Thr184Met Single submitter ⚠
- p.Thr22Ile Single submitter ⚠
- p.Thr97Met Single submitter ⚠
- p.Tyr134His Single submitter ⚠
- p.Val50Met Single submitter ⚠