CIMAP1B — 37 ClinVar variants
All ClinVar germline CIMAP1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
37 Uncertain significance
Full CIMAP1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CIMAP1B p.Ala134Glu Uncertain significance Single submitter
- CIMAP1B p.Ala134Val Uncertain significance Single submitter
- CIMAP1B p.Ala143Val Uncertain significance Single submitter
- CIMAP1B p.Ala245Thr Uncertain significance Single submitter
- CIMAP1B p.Ala39Thr Uncertain significance Single submitter
- CIMAP1B p.Ala84Ser Uncertain significance Single submitter
- CIMAP1B p.Ala97Val Uncertain significance Single submitter
- CIMAP1B p.Asn224Tyr Uncertain significance Single submitter
- CIMAP1B p.Asp4Asn Uncertain significance Single submitter
- CIMAP1B p.Cys64Arg Uncertain significance Single submitter
- CIMAP1B p.Gln201Arg Uncertain significance Single submitter
- CIMAP1B p.Glu176Gln Uncertain significance Single submitter
- CIMAP1B p.Gly131Val Uncertain significance Single submitter
- CIMAP1B p.Gly167Arg Uncertain significance Single submitter
- CIMAP1B p.Gly25Val Uncertain significance Single submitter
- CIMAP1B p.His228Arg Uncertain significance Single submitter
- CIMAP1B p.Leu150Trp Uncertain significance Single submitter
- CIMAP1B p.Lys217Thr Uncertain significance Single submitter
- CIMAP1B p.Pro15Ser Uncertain significance Single submitter
- CIMAP1B p.Pro98Thr Uncertain significance Single submitter
- CIMAP1B p.Ser138Asn Uncertain significance Single submitter
- CIMAP1B p.Ser173Thr Uncertain significance Single submitter
- CIMAP1B p.Ser3Leu Uncertain significance Single submitter
- CIMAP1B p.Tyr23Cys Uncertain significance Single submitter
- CIMAP1B p.Tyr38His Uncertain significance Single submitter
- CIMAP1B p.Val78Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- CIMAP1B p.Arg207Gln Uncertain significance Single submitter
- CIMAP1B p.Arg56Leu Uncertain significance Single submitter
- CIMAP1B p.Arg92His Uncertain significance Single submitter
- CIMAP1B p.Gly54Ser Uncertain significance Single submitter
- CIMAP1B p.Met76Lys Uncertain significance Single submitter
- CIMAP1B p.Phe236Leu Uncertain significance Single submitter
- CIMAP1B p.Pro121Leu Uncertain significance Single submitter
- CIMAP1B p.Pro33Gln Uncertain significance Single submitter
- CIMAP1B p.Pro43Leu Uncertain significance Single submitter
- CIMAP1B p.Thr77Ile Uncertain significance Single submitter
All CIMAP1B variants
Uncertain significance 37
- p.Ala134Glu Single submitter ⚠
- p.Ala134Val Single submitter ⚠
- p.Ala143Val Single submitter ⚠
- p.Ala245Thr Single submitter ⚠
- p.Ala39Thr Single submitter ⚠
- p.Ala84Ser Single submitter ⚠
- p.Ala97Val Single submitter ⚠
- p.Arg16Cys Single submitter
- p.Arg207Gln Single submitter ⚠
- p.Arg56Leu Single submitter ⚠
- p.Arg92His Single submitter ⚠
- p.Asn224Tyr Single submitter ⚠
- p.Asp4Asn Single submitter ⚠
- p.Cys64Arg Single submitter ⚠
- p.Gln201Arg Single submitter ⚠
- p.Glu176Gln Single submitter ⚠
- p.Gly131Val Single submitter ⚠
- p.Gly167Arg Single submitter ⚠
- p.Gly25Val Single submitter ⚠
- p.Gly54Ser Single submitter ⚠
- p.His228Arg Single submitter ⚠
- p.Leu150Trp Single submitter ⚠
- p.Lys217Thr Single submitter ⚠
- p.Met76Lys Single submitter ⚠
- p.Phe236Leu Single submitter ⚠
- p.Pro121Leu Single submitter ⚠
- p.Pro15Ser Single submitter ⚠
- p.Pro33Gln Single submitter ⚠
- p.Pro43Leu Single submitter ⚠
- p.Pro98Thr Single submitter ⚠
- p.Ser138Asn Single submitter ⚠
- p.Ser173Thr Single submitter ⚠
- p.Ser3Leu Single submitter ⚠
- p.Thr77Ile Single submitter ⚠
- p.Tyr23Cys Single submitter ⚠
- p.Tyr38His Single submitter ⚠
- p.Val78Leu Single submitter ⚠