CIMAP2 — 62 ClinVar variants
All ClinVar germline CIMAP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
2 Likely benign · 60 Uncertain significance
Full CIMAP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 42
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CIMAP2 p.Ala7Val Uncertain significance Single submitter
- CIMAP2 p.Ala8Thr Uncertain significance Single submitter
- CIMAP2 p.Arg203Trp Uncertain significance Single submitter
- CIMAP2 p.Arg306His Uncertain significance Single submitter
- CIMAP2 p.Arg374Gly Uncertain significance Single submitter
- CIMAP2 p.Arg390Gln Uncertain significance Single submitter
- CIMAP2 p.Arg59His Uncertain significance Single submitter
- CIMAP2 p.Asn351Ser Uncertain significance Single submitter
- CIMAP2 p.Asp220Asn Uncertain significance Single submitter
- CIMAP2 p.Cys78Gly Uncertain significance Single submitter
- CIMAP2 p.Gln303His Uncertain significance Single submitter
- CIMAP2 p.Glu171Ala Uncertain significance Single submitter
- CIMAP2 p.Glu294Ala Uncertain significance Single submitter
- CIMAP2 p.Glu3Gln Uncertain significance Single submitter
- CIMAP2 p.Gly191Ala Uncertain significance Single submitter
- CIMAP2 p.Gly191Ser Uncertain significance Single submitter
- CIMAP2 p.Gly191Val Uncertain significance Single submitter
- CIMAP2 p.Gly233Ser Uncertain significance Single submitter
- CIMAP2 p.Gly26Ala Uncertain significance Single submitter
- CIMAP2 p.His201Tyr Uncertain significance Single submitter
- CIMAP2 p.His279Tyr Uncertain significance Single submitter
- CIMAP2 p.Lys178Arg Uncertain significance Single submitter
- CIMAP2 p.Lys255Glu Uncertain significance Single submitter
- CIMAP2 p.Lys256Asn Uncertain significance Single submitter
- CIMAP2 p.Met196Ile Uncertain significance Single submitter
- CIMAP2 p.Met262Val Uncertain significance Single submitter
- CIMAP2 p.Pro313Ser Uncertain significance Single submitter
- CIMAP2 p.Pro329Arg Uncertain significance Single submitter
- CIMAP2 p.Pro43Arg Uncertain significance Single submitter
- CIMAP2 p.Pro55Leu Uncertain significance Single submitter
- CIMAP2 p.Ser127Tyr Uncertain significance Single submitter
- CIMAP2 p.Ser239Cys Uncertain significance Single submitter
- CIMAP2 p.Ser4Arg Uncertain significance Single submitter
- CIMAP2 p.Thr231Pro Uncertain significance Single submitter
- CIMAP2 p.Thr237Ala Uncertain significance Single submitter
- CIMAP2 p.Thr334Pro Uncertain significance Single submitter
- CIMAP2 p.Thr62Asn Uncertain significance Single submitter
- CIMAP2 p.Thr99Met Uncertain significance Single submitter
- CIMAP2 p.Trp298Arg Uncertain significance Single submitter
- CIMAP2 p.Val268Ile Uncertain significance Single submitter
- CIMAP2 p.Val281Phe Uncertain significance Single submitter
- CIMAP2 p.Val31Leu Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- CIMAP2 p.Arg117Trp Uncertain significance Single submitter
- CIMAP2 p.Arg145Trp Uncertain significance Single submitter
- CIMAP2 p.Arg186Gln Uncertain significance Single submitter
- CIMAP2 p.Arg232Cys Uncertain significance Single submitter
- CIMAP2 p.Arg242Gln Uncertain significance Single submitter
- CIMAP2 p.Arg370Pro Uncertain significance Single submitter
- CIMAP2 p.Arg374Pro Uncertain significance Single submitter
- CIMAP2 p.Arg59Cys Uncertain significance Single submitter
- CIMAP2 p.Gly173Asp Uncertain significance Single submitter
- CIMAP2 p.Leu118Val Uncertain significance Single submitter
- CIMAP2 p.Pro28Leu Uncertain significance Single submitter
- CIMAP2 p.Pro69Arg Uncertain significance Single submitter
- CIMAP2 p.Ser33Asn Uncertain significance Single submitter
- CIMAP2 p.Ser57Cys Uncertain significance Single submitter
- CIMAP2 p.Thr144Ile Uncertain significance Single submitter
- CIMAP2 p.Tyr169Ser Uncertain significance Single submitter
- CIMAP2 p.Tyr176His Uncertain significance Single submitter
- CIMAP2 p.Val31Met Uncertain significance Single submitter
All CIMAP2 variants
Likely benign 2
- p.Gln63Glu Single submitter
- p.Gly12= Single submitter
Uncertain significance 60
- p.Ala7Val Single submitter ⚠
- p.Ala8Thr Single submitter ⚠
- p.Arg117Trp Single submitter ⚠
- p.Arg145Trp Single submitter ⚠
- p.Arg186Gln Single submitter ⚠
- p.Arg203Trp Single submitter ⚠
- p.Arg232Cys Single submitter ⚠
- p.Arg242Gln Single submitter ⚠
- p.Arg306His Single submitter ⚠
- p.Arg370Pro Single submitter ⚠
- p.Arg374Gly Single submitter ⚠
- p.Arg374Pro Single submitter ⚠
- p.Arg390Gln Single submitter ⚠
- p.Arg59Cys Single submitter ⚠
- p.Arg59His Single submitter ⚠
- p.Asn351Ser Single submitter ⚠
- p.Asp220Asn Single submitter ⚠
- p.Cys78Gly Single submitter ⚠
- p.Gln303His Single submitter ⚠
- p.Glu171Ala Single submitter ⚠
- p.Glu294Ala Single submitter ⚠
- p.Glu3Gln Single submitter ⚠
- p.Gly173Asp Single submitter ⚠
- p.Gly191Ala Single submitter ⚠
- p.Gly191Ser Single submitter ⚠
- p.Gly191Val Single submitter ⚠
- p.Gly233Ser Single submitter ⚠
- p.Gly26Ala Single submitter ⚠
- p.His201Tyr Single submitter ⚠
- p.His279Tyr Single submitter ⚠
- p.Leu118Val Single submitter ⚠
- p.Lys178Arg Single submitter ⚠
- p.Lys255Glu Single submitter ⚠
- p.Lys256Asn Single submitter ⚠
- p.Met196Ile Single submitter ⚠
- p.Met262Val Single submitter ⚠
- p.Pro28Leu Single submitter ⚠
- p.Pro313Ser Single submitter ⚠
- p.Pro329Arg Single submitter ⚠
- p.Pro43Arg Single submitter ⚠
- p.Pro55Leu Single submitter ⚠
- p.Pro69Arg Single submitter ⚠
- p.Ser127Tyr Single submitter ⚠
- p.Ser239Cys Single submitter ⚠
- p.Ser33Asn Single submitter ⚠
- p.Ser4Arg Single submitter ⚠
- p.Ser57Cys Single submitter ⚠
- p.Thr144Ile Single submitter ⚠
- p.Thr231Pro Single submitter ⚠
- p.Thr237Ala Single submitter ⚠
- p.Thr334Pro Single submitter ⚠
- p.Thr62Asn Single submitter ⚠
- p.Thr99Met Single submitter ⚠
- p.Trp298Arg Single submitter ⚠
- p.Tyr169Ser Single submitter ⚠
- p.Tyr176His Single submitter ⚠
- p.Val268Ile Single submitter ⚠
- p.Val281Phe Single submitter ⚠
- p.Val31Leu Single submitter ⚠
- p.Val31Met Single submitter ⚠