CIMAP3 — 20 ClinVar variants
All ClinVar germline CIMAP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 20 flagged for review →
20 Uncertain significance
Full CIMAP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 20
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CIMAP3 p.Ala110Val Uncertain significance Single submitter
- CIMAP3 p.Ala145Gly Uncertain significance Single submitter
- CIMAP3 p.Arg94Lys Uncertain significance Single submitter
- CIMAP3 p.Asn181Asp Uncertain significance Single submitter
- CIMAP3 p.Gln162Arg Uncertain significance Single submitter
- CIMAP3 p.Gly56Cys Uncertain significance Single submitter
- CIMAP3 p.Lys120Thr Uncertain significance Single submitter
- CIMAP3 p.Met148Val Uncertain significance Single submitter
- CIMAP3 p.Pro140Ser Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- CIMAP3 p.Arg182Cys Uncertain significance Single submitter
- CIMAP3 p.Arg182His Uncertain significance Single submitter
- CIMAP3 p.Gly33Arg Uncertain significance Single submitter
- CIMAP3 p.Leu186Val Uncertain significance Single submitter
- CIMAP3 p.Lys138Asn Uncertain significance Single submitter
- CIMAP3 p.Lys69Asn Uncertain significance Single submitter
- CIMAP3 p.Phe23Leu Uncertain significance Single submitter
- CIMAP3 p.Pro136Leu Uncertain significance Single submitter
- CIMAP3 p.Ser67Gly Uncertain significance Single submitter
- CIMAP3 p.Thr16Ala Uncertain significance Single submitter
- CIMAP3 p.Thr77Ile Uncertain significance Single submitter
All CIMAP3 variants
Uncertain significance 20
- p.Ala110Val Single submitter ⚠
- p.Ala145Gly Single submitter ⚠
- p.Arg182Cys Single submitter ⚠
- p.Arg182His Single submitter ⚠
- p.Arg94Lys Single submitter ⚠
- p.Asn181Asp Single submitter ⚠
- p.Gln162Arg Single submitter ⚠
- p.Gly33Arg Single submitter ⚠
- p.Gly56Cys Single submitter ⚠
- p.Leu186Val Single submitter ⚠
- p.Lys120Thr Single submitter ⚠
- p.Lys138Asn Single submitter ⚠
- p.Lys69Asn Single submitter ⚠
- p.Met148Val Single submitter ⚠
- p.Phe23Leu Single submitter ⚠
- p.Pro136Leu Single submitter ⚠
- p.Pro140Ser Single submitter ⚠
- p.Ser67Gly Single submitter ⚠
- p.Thr16Ala Single submitter ⚠
- p.Thr77Ile Single submitter ⚠