CIMIP2C — 5 ClinVar variants
All ClinVar germline CIMIP2C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 5 flagged for review →
5 Uncertain significance
Full CIMIP2C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 5
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 2
The independent predictors disagree with each other — read with care.
All CIMIP2C variants
Uncertain significance 5
- p.Asp51Tyr Single submitter ⚠
- p.Gly42Ser Single submitter ⚠
- p.Pro136Ser Single submitter ⚠
- p.Thr112Met Single submitter ⚠
- p.Thr45Asn Single submitter ⚠