CIMIP4 — 59 ClinVar variants
All ClinVar germline CIMIP4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 50 flagged for review →
9 Likely benign · 50 Uncertain significance
Full CIMIP4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 50
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CIMIP4 p.Ala107Val Uncertain significance Single submitter
- CIMIP4 p.Ala256Val Uncertain significance Single submitter
- CIMIP4 p.Ala31Val Uncertain significance Single submitter
- CIMIP4 p.Ala96Val Uncertain significance Single submitter
- CIMIP4 p.Arg206Gln Uncertain significance Single submitter
- CIMIP4 p.Arg206Trp Uncertain significance Single submitter
- CIMIP4 p.Asp121Asn Uncertain significance Single submitter
- CIMIP4 p.Asp156Asn Uncertain significance Single submitter
- CIMIP4 p.Asp200Gly Uncertain significance Single submitter
- CIMIP4 p.Asp236His Uncertain significance Single submitter
- CIMIP4 p.Asp37Asn Uncertain significance Single submitter
- CIMIP4 p.Gln128Pro Uncertain significance Single submitter
- CIMIP4 p.Glu104Gln Uncertain significance Single submitter
- CIMIP4 p.Glu161Lys Uncertain significance Single submitter
- CIMIP4 p.Glu173Lys Uncertain significance Single submitter
- CIMIP4 p.Glu190Val Uncertain significance Single submitter
- CIMIP4 p.Glu267Asp Uncertain significance Single submitter
- CIMIP4 p.Glu271Val Uncertain significance Single submitter
- CIMIP4 p.Glu70Lys Uncertain significance Single submitter
- CIMIP4 p.Gly122Ser Uncertain significance Single submitter
- CIMIP4 p.Gly4Asp Uncertain significance Single submitter
- CIMIP4 p.His67Asp Uncertain significance Single submitter
- CIMIP4 p.Lys232Arg Uncertain significance Single submitter
- CIMIP4 p.Lys40Arg Uncertain significance Single submitter
- CIMIP4 p.Met86Leu Uncertain significance Single submitter
- CIMIP4 p.Phe12Val Uncertain significance Single submitter
- CIMIP4 p.Phe41Leu Uncertain significance Single submitter
- CIMIP4 p.Pro182Ser Uncertain significance Single submitter
- CIMIP4 p.Pro73Ser Uncertain significance Single submitter
- CIMIP4 p.Pro75Leu Uncertain significance Single submitter
- CIMIP4 p.Ser179Arg Uncertain significance Single submitter
- CIMIP4 p.Ser193Ala Uncertain significance Single submitter
- CIMIP4 p.Ser233Thr Uncertain significance Single submitter
- CIMIP4 p.Ser47Thr Uncertain significance Single submitter
- CIMIP4 p.Thr108Ile Uncertain significance Single submitter
- CIMIP4 p.Thr217Lys Uncertain significance Single submitter
- CIMIP4 p.Thr38Pro Uncertain significance Single submitter
- CIMIP4 p.Tyr198Phe Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- CIMIP4 p.Asn260Lys Uncertain significance Multiple submitters
- CIMIP4 p.Arg250Trp Uncertain significance Single submitter
- CIMIP4 p.Gly202Arg Uncertain significance Single submitter
- CIMIP4 p.Gly97Cys Uncertain significance Single submitter
- CIMIP4 p.Ile142Thr Uncertain significance Single submitter
- CIMIP4 p.Ile168Thr Uncertain significance Single submitter
- CIMIP4 p.Met257Ile Uncertain significance Single submitter
- CIMIP4 p.Ser180Leu Uncertain significance Single submitter
- CIMIP4 p.Ser273Asn Uncertain significance Single submitter
- CIMIP4 p.Ser278Ala Uncertain significance Single submitter
- CIMIP4 p.Thr133Met Uncertain significance Single submitter
- CIMIP4 p.Tyr199Cys Uncertain significance Single submitter
All CIMIP4 variants
Likely benign 9
- p.Arg211Gln Single submitter
- p.Gln59Arg Single submitter
- p.Gly139Ser Single submitter
- p.Gly6Arg Single submitter
- p.Leu84Pro Single submitter
- p.Phe12Leu Single submitter
- p.Ser109Leu Single submitter
- p.Val171Ala Single submitter
- p.Val194Ile Single submitter
Uncertain significance 50
- p.Asn260Lys Multiple submitters ⚠
- p.Ala107Val Single submitter ⚠
- p.Ala256Val Single submitter ⚠
- p.Ala31Val Single submitter ⚠
- p.Ala96Val Single submitter ⚠
- p.Arg206Gln Single submitter ⚠
- p.Arg206Trp Single submitter ⚠
- p.Arg250Trp Single submitter ⚠
- p.Asp121Asn Single submitter ⚠
- p.Asp156Asn Single submitter ⚠
- p.Asp200Gly Single submitter ⚠
- p.Asp236His Single submitter ⚠
- p.Asp37Asn Single submitter ⚠
- p.Gln128Pro Single submitter ⚠
- p.Glu104Gln Single submitter ⚠
- p.Glu161Lys Single submitter ⚠
- p.Glu173Lys Single submitter ⚠
- p.Glu190Val Single submitter ⚠
- p.Glu267Asp Single submitter ⚠
- p.Glu271Val Single submitter ⚠
- p.Glu70Lys Single submitter ⚠
- p.Gly122Ser Single submitter ⚠
- p.Gly202Arg Single submitter ⚠
- p.Gly4Asp Single submitter ⚠
- p.Gly97Cys Single submitter ⚠
- p.His67Asp Single submitter ⚠
- p.Ile142Thr Single submitter ⚠
- p.Ile168Thr Single submitter ⚠
- p.Lys232Arg Single submitter ⚠
- p.Lys40Arg Single submitter ⚠
- p.Met257Ile Single submitter ⚠
- p.Met86Leu Single submitter ⚠
- p.Phe12Val Single submitter ⚠
- p.Phe41Leu Single submitter ⚠
- p.Pro182Ser Single submitter ⚠
- p.Pro73Ser Single submitter ⚠
- p.Pro75Leu Single submitter ⚠
- p.Ser179Arg Single submitter ⚠
- p.Ser180Leu Single submitter ⚠
- p.Ser193Ala Single submitter ⚠
- p.Ser233Thr Single submitter ⚠
- p.Ser273Asn Single submitter ⚠
- p.Ser278Ala Single submitter ⚠
- p.Ser47Thr Single submitter ⚠
- p.Thr108Ile Single submitter ⚠
- p.Thr133Met Single submitter ⚠
- p.Thr217Lys Single submitter ⚠
- p.Thr38Pro Single submitter ⚠
- p.Tyr198Phe Single submitter ⚠
- p.Tyr199Cys Single submitter ⚠