CIP2A — 131 ClinVar variants

All ClinVar germline CIP2A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 122 flagged for review →

3 Benign · 6 Likely benign · 122 Uncertain significance

Full CIP2A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 122

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 58

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 64

The independent predictors disagree with each other — read with care.

All CIP2A variants

Benign 3

p.His314Arg Multiple submitters
p.Ser213Phe Multiple submitters
p.Ile759Val Single submitter

Likely benign 6

p.Asp353= Multiple submitters
c.1114-6C>A Single submitter
p.Ala329Thr Single submitter
p.Gly78Ser Single submitter
p.Ile581Val Single submitter
p.Pro326Ser Single submitter

Uncertain significance 122

p.Ala268Val Single submitter ⚠
p.Ala26Gly Single submitter ⚠
p.Ala362Thr Single submitter ⚠
p.Ala535Thr Single submitter ⚠
p.Ala695Val Single submitter ⚠
p.Ala84Glu Single submitter ⚠
p.Arg109Trp Single submitter ⚠
p.Arg171Gln Single submitter ⚠
p.Arg171Trp Single submitter ⚠
p.Arg191Gln Single submitter ⚠
p.Arg313Cys Single submitter ⚠
p.Arg313His Single submitter ⚠
p.Arg384Ser Single submitter ⚠
p.Arg410Gly Single submitter ⚠
p.Arg508His Single submitter ⚠
p.Arg566Lys Single submitter ⚠
p.Arg566Ser Single submitter ⚠
p.Arg662Cys Single submitter ⚠
p.Arg662His Single submitter ⚠
p.Arg715Lys Single submitter ⚠
p.Arg737Gly Single submitter ⚠
p.Arg863Cys Single submitter ⚠
p.Arg863His Single submitter ⚠
p.Asn67Ser Single submitter ⚠
p.Asn686Ser Single submitter ⚠
p.Asn756Ser Single submitter ⚠
p.Asn792Tyr Single submitter ⚠
p.Asp141Asn Single submitter ⚠
p.Asp141Gly Single submitter ⚠
p.Asp156Val Single submitter ⚠
p.Asp383Glu Single submitter ⚠
p.Asp520Val Single submitter ⚠
p.Asp621Val Single submitter ⚠
p.Asp624Gly Single submitter ⚠
p.Asp747His Single submitter ⚠
p.Cys108Phe Single submitter ⚠
p.Cys108Ser Single submitter ⚠
p.Cys358Gly Single submitter ⚠
p.Cys472Arg Single submitter ⚠
p.Gln152Pro Single submitter ⚠
p.Gln39His Single submitter ⚠
p.Gln806Pro Single submitter ⚠
p.Glu275Gln Single submitter ⚠
p.Glu356Lys Single submitter ⚠
p.Glu406Gln Single submitter ⚠
p.Glu450Gln Single submitter ⚠
p.Glu602Gln Single submitter ⚠
p.Glu681Lys Single submitter ⚠
p.Glu683Lys Single submitter ⚠
p.Glu701Ala Single submitter ⚠
p.Glu782Lys Single submitter ⚠
p.Glu821Lys Single submitter ⚠
p.Glu868Gln Single submitter ⚠
p.Gly222Arg Single submitter ⚠
p.Gly286Val Single submitter ⚠
p.Gly38Glu Single submitter ⚠
p.Gly591Asp Single submitter ⚠
p.Gly591Val Single submitter ⚠
p.Gly862Cys Single submitter ⚠
p.His282Gln Single submitter ⚠
p.His563Leu Single submitter ⚠
p.Ile133Thr Single submitter ⚠
p.Ile180Val Single submitter ⚠
p.Ile194Phe Single submitter ⚠
p.Ile211Met Single submitter ⚠
p.Ile267Thr Single submitter ⚠
p.Ile449Val Single submitter ⚠
p.Ile781Leu Single submitter ⚠
p.Ile829Thr Single submitter ⚠
p.Ile842Met Single submitter ⚠
p.Ile87Val Single submitter ⚠
p.Leu12Val Single submitter ⚠
p.Leu262Phe Single submitter ⚠
p.Leu281Phe Single submitter ⚠
p.Leu397Phe Single submitter ⚠
p.Leu492Phe Single submitter ⚠
p.Leu689Ile Single submitter ⚠
p.Lys21Glu Single submitter ⚠
p.Lys636Glu Single submitter ⚠
p.Lys716Asn Single submitter ⚠
p.Lys716Thr Single submitter ⚠
p.Lys820Asn Single submitter ⚠
p.Lys820Thr Single submitter ⚠
p.Met160Ile Single submitter ⚠
p.Met496Val Single submitter ⚠
p.Met623Val Single submitter ⚠
p.Met678Leu Single submitter ⚠
p.Met887Thr Single submitter ⚠
p.Phe321Ser Single submitter ⚠
p.Phe500Val Single submitter ⚠
p.Pro161Ala Single submitter ⚠
p.Pro351Arg Single submitter ⚠
p.Pro494Leu Single submitter ⚠
p.Ser115Leu Single submitter ⚠
p.Ser115Pro Single submitter ⚠
p.Ser115Trp Single submitter ⚠
p.Ser279Leu Single submitter ⚠
p.Ser297Leu Single submitter ⚠
p.Ser333Arg Single submitter ⚠
p.Ser355Leu Single submitter ⚠
p.Ser381Leu Single submitter ⚠
p.Ser3Cys Single submitter ⚠
p.Ser53Gly Single submitter ⚠
p.Ser576Arg Single submitter ⚠
p.Ser851Thr Single submitter ⚠
p.Ser904Gly Single submitter ⚠
p.Ser9Phe Single submitter ⚠
p.Thr145Met Single submitter ⚠
p.Thr192Ala Single submitter ⚠
p.Thr341Ser Single submitter ⚠
p.Thr392Ala Single submitter ⚠
p.Thr46Ile Single submitter ⚠
p.Thr828Ala Single submitter ⚠
p.Thr89Ser Single submitter ⚠
p.Trp570Ser Single submitter ⚠
p.Tyr135Ser Single submitter ⚠
p.Tyr274Cys Single submitter ⚠
p.Tyr274His Single submitter ⚠
p.Tyr455His Single submitter ⚠
p.Val205Ile Single submitter ⚠
p.Val284Leu Single submitter ⚠
p.Val810Ile Single submitter ⚠