CIPC — 61 ClinVar variants
All ClinVar germline CIPC variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
2 Likely benign · 59 Uncertain significance
Full CIPC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CIPC p.Ala220Thr Uncertain significance Single submitter
- CIPC p.Ala373Ser Uncertain significance Single submitter
- CIPC p.Arg29His Uncertain significance Single submitter
- CIPC p.Arg301Cys Uncertain significance Single submitter
- CIPC p.Arg301His Uncertain significance Single submitter
- CIPC p.Arg310Gln Uncertain significance Single submitter
- CIPC p.Asn288His Uncertain significance Single submitter
- CIPC p.Asn385Asp Uncertain significance Single submitter
- CIPC p.Asp149Asn Uncertain significance Single submitter
- CIPC p.Asp395Asn Uncertain significance Single submitter
- CIPC p.Asp62Gly Uncertain significance Single submitter
- CIPC p.Asp73Glu Uncertain significance Single submitter
- CIPC p.Glu201Lys Uncertain significance Single submitter
- CIPC p.Glu224Lys Uncertain significance Single submitter
- CIPC p.Glu61Lys Uncertain significance Single submitter
- CIPC p.Gly206Asp Uncertain significance Single submitter
- CIPC p.Gly230Ser Uncertain significance Single submitter
- CIPC p.Gly68Ser Uncertain significance Single submitter
- CIPC p.His314Arg Uncertain significance Single submitter
- CIPC p.His325Arg Uncertain significance Single submitter
- CIPC p.His396Asp Uncertain significance Single submitter
- CIPC p.Leu109Arg Uncertain significance Single submitter
- CIPC p.Leu172Arg Uncertain significance Single submitter
- CIPC p.Leu172Pro Uncertain significance Single submitter
- CIPC p.Leu89Pro Uncertain significance Single submitter
- CIPC p.Lys101Arg Uncertain significance Single submitter
- CIPC p.Lys337Thr Uncertain significance Single submitter
- CIPC p.Phe129Leu Uncertain significance Single submitter
- CIPC p.Phe259Ile Uncertain significance Single submitter
- CIPC p.Phe393Leu Uncertain significance Single submitter
- CIPC p.Pro217Ser Uncertain significance Single submitter
- CIPC p.Pro218Ser Uncertain significance Single submitter
- CIPC p.Pro292Ala Uncertain significance Single submitter
- CIPC p.Pro397Ser Uncertain significance Single submitter
- CIPC p.Pro6Arg Uncertain significance Single submitter
- CIPC p.Pro75Leu Uncertain significance Single submitter
- CIPC p.Ser249Gly Uncertain significance Single submitter
- CIPC p.Val184Ala Uncertain significance Single submitter
- CIPC p.Val246Ile Uncertain significance Single submitter
- CIPC p.Val251Met Uncertain significance Single submitter
- CIPC p.Val322Leu Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- CIPC p.Arg310Trp Uncertain significance Single submitter
- CIPC p.Asn319Ser Uncertain significance Single submitter
- CIPC p.Gln342Arg Uncertain significance Single submitter
- CIPC p.His166Gln Uncertain significance Single submitter
- CIPC p.Ile340Met Uncertain significance Single submitter
- CIPC p.Leu197Phe Uncertain significance Single submitter
- CIPC p.Lys162Glu Uncertain significance Single submitter
- CIPC p.Lys186Arg Uncertain significance Single submitter
- CIPC p.Pro381Ala Uncertain significance Single submitter
- CIPC p.Pro381Arg Uncertain significance Single submitter
- CIPC p.Pro381Ser Likely benign Single submitter
- CIPC p.Ser104Arg Uncertain significance Single submitter
- CIPC p.Ser247Cys Uncertain significance Single submitter
- CIPC p.Ser248Arg Uncertain significance Single submitter
- CIPC p.Ser283Thr Uncertain significance Single submitter
- CIPC p.Ser291Leu Uncertain significance Single submitter
- CIPC p.Ser42Thr Uncertain significance Single submitter
- CIPC p.Thr81Ile Uncertain significance Single submitter
- CIPC p.Val120Leu Uncertain significance Single submitter
All CIPC variants
Likely benign 2
- p.Lys374Arg Single submitter
- p.Pro381Ser Single submitter ⚠
Uncertain significance 59
- p.Ala220Thr Single submitter ⚠
- p.Ala373Ser Single submitter ⚠
- p.Arg29His Single submitter ⚠
- p.Arg301Cys Single submitter ⚠
- p.Arg301His Single submitter ⚠
- p.Arg310Gln Single submitter ⚠
- p.Arg310Trp Single submitter ⚠
- p.Asn288His Single submitter ⚠
- p.Asn319Ser Single submitter ⚠
- p.Asn385Asp Single submitter ⚠
- p.Asp149Asn Single submitter ⚠
- p.Asp395Asn Single submitter ⚠
- p.Asp62Gly Single submitter ⚠
- p.Asp73Glu Single submitter ⚠
- p.Gln342Arg Single submitter ⚠
- p.Glu201Lys Single submitter ⚠
- p.Glu224Lys Single submitter ⚠
- p.Glu61Lys Single submitter ⚠
- p.Gly206Asp Single submitter ⚠
- p.Gly230Ser Single submitter ⚠
- p.Gly68Ser Single submitter ⚠
- p.His166Gln Single submitter ⚠
- p.His314Arg Single submitter ⚠
- p.His325Arg Single submitter ⚠
- p.His396Asp Single submitter ⚠
- p.Ile340Met Single submitter ⚠
- p.Leu109Arg Single submitter ⚠
- p.Leu172Arg Single submitter ⚠
- p.Leu172Pro Single submitter ⚠
- p.Leu197Phe Single submitter ⚠
- p.Leu89Pro Single submitter ⚠
- p.Lys101Arg Single submitter ⚠
- p.Lys162Glu Single submitter ⚠
- p.Lys186Arg Single submitter ⚠
- p.Lys337Thr Single submitter ⚠
- p.Phe129Leu Single submitter ⚠
- p.Phe259Ile Single submitter ⚠
- p.Phe393Leu Single submitter ⚠
- p.Pro217Ser Single submitter ⚠
- p.Pro218Ser Single submitter ⚠
- p.Pro292Ala Single submitter ⚠
- p.Pro381Ala Single submitter ⚠
- p.Pro381Arg Single submitter ⚠
- p.Pro397Ser Single submitter ⚠
- p.Pro6Arg Single submitter ⚠
- p.Pro75Leu Single submitter ⚠
- p.Ser104Arg Single submitter ⚠
- p.Ser247Cys Single submitter ⚠
- p.Ser248Arg Single submitter ⚠
- p.Ser249Gly Single submitter ⚠
- p.Ser283Thr Single submitter ⚠
- p.Ser291Leu Single submitter ⚠
- p.Ser42Thr Single submitter ⚠
- p.Thr81Ile Single submitter ⚠
- p.Val120Leu Single submitter ⚠
- p.Val184Ala Single submitter ⚠
- p.Val246Ile Single submitter ⚠
- p.Val251Met Single submitter ⚠
- p.Val322Leu Single submitter ⚠