CISD3 — 20 ClinVar variants
All ClinVar germline CISD3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 20 flagged for review →
20 Uncertain significance
Full CISD3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 20
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CISD3 p.Ala12Thr Uncertain significance Single submitter
- CISD3 p.Ala29Thr Uncertain significance Single submitter
- CISD3 p.Ala29Val Uncertain significance Single submitter
- CISD3 p.Arg117His Uncertain significance Single submitter
- CISD3 p.Arg16Pro Uncertain significance Single submitter
- CISD3 p.Arg79His Uncertain significance Single submitter
- CISD3 p.Gln68Lys Uncertain significance Single submitter
- CISD3 p.Gly63Asp Uncertain significance Single submitter
- CISD3 p.Gly63Ser Uncertain significance Single submitter
- CISD3 p.Met94Ile Uncertain significance Single submitter
- CISD3 p.Pro10Leu Uncertain significance Single submitter
- CISD3 p.Val52Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- CISD3 p.Ala29Pro Uncertain significance Single submitter
- CISD3 p.Arg58Ser Uncertain significance Single submitter
- CISD3 p.Gly54Glu Uncertain significance Single submitter
- CISD3 p.Ile47Asn Uncertain significance Single submitter
- CISD3 p.Pro84Ser Uncertain significance Single submitter
- CISD3 p.Thr92Ile Uncertain significance Single submitter
- CISD3 p.Val40Met Uncertain significance Single submitter
- CISD3 p.Val41Met Uncertain significance Single submitter
All CISD3 variants
Uncertain significance 20
- p.Ala12Thr Single submitter ⚠
- p.Ala29Pro Single submitter ⚠
- p.Ala29Thr Single submitter ⚠
- p.Ala29Val Single submitter ⚠
- p.Arg117His Single submitter ⚠
- p.Arg16Pro Single submitter ⚠
- p.Arg58Ser Single submitter ⚠
- p.Arg79His Single submitter ⚠
- p.Gln68Lys Single submitter ⚠
- p.Gly54Glu Single submitter ⚠
- p.Gly63Asp Single submitter ⚠
- p.Gly63Ser Single submitter ⚠
- p.Ile47Asn Single submitter ⚠
- p.Met94Ile Single submitter ⚠
- p.Pro10Leu Single submitter ⚠
- p.Pro84Ser Single submitter ⚠
- p.Thr92Ile Single submitter ⚠
- p.Val40Met Single submitter ⚠
- p.Val41Met Single submitter ⚠
- p.Val52Met Single submitter ⚠