CITED4 — 45 ClinVar variants
All ClinVar germline CITED4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
1 Likely benign · 44 Uncertain significance
Full CITED4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CITED4 p.Ala22Gly Uncertain significance Single submitter
- CITED4 p.Arg30Gln Uncertain significance Single submitter
- CITED4 p.Arg57Gly Uncertain significance Single submitter
- CITED4 p.Asn105His Uncertain significance Single submitter
- CITED4 p.Asp3Gly Uncertain significance Single submitter
- CITED4 p.Gln114Pro Uncertain significance Single submitter
- CITED4 p.Glu148Asp Uncertain significance Single submitter
- CITED4 p.Glu159Lys Uncertain significance Single submitter
- CITED4 p.Gly25Val Uncertain significance Single submitter
- CITED4 p.His88Pro Uncertain significance Single submitter
- CITED4 p.Ile137Val Uncertain significance Single submitter
- CITED4 p.Ile86Val Uncertain significance Single submitter
- CITED4 p.Leu29Phe Uncertain significance Single submitter
- CITED4 p.Pro46Leu Uncertain significance Single submitter
- CITED4 p.Pro80Ala Uncertain significance Single submitter
- CITED4 p.Pro82Ser Uncertain significance Single submitter
- CITED4 p.Pro95Arg Uncertain significance Single submitter
- CITED4 p.Pro97Arg Uncertain significance Single submitter
- CITED4 p.Ser175Pro Uncertain significance Single submitter
- CITED4 p.Thr143Pro Uncertain significance Single submitter
- CITED4 p.Val14Gly Uncertain significance Single submitter
- CITED4 p.Val182Ala Uncertain significance Single submitter
- CITED4 p.Val182Gly Uncertain significance Single submitter
- CITED4 p.Val92Leu Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- CITED4 p.Ala116Thr Uncertain significance Single submitter
- CITED4 p.Ala28Val Uncertain significance Single submitter
- CITED4 p.Ala93Glu Uncertain significance Single submitter
- CITED4 p.Arg155Cys Uncertain significance Single submitter
- CITED4 p.Arg155Gly Uncertain significance Single submitter
- CITED4 p.Arg30Trp Uncertain significance Single submitter
- CITED4 p.Asp172Glu Uncertain significance Single submitter
- CITED4 p.Gly25Cys Uncertain significance Single submitter
- CITED4 p.Leu136Val Uncertain significance Single submitter
- CITED4 p.Phe67Leu Uncertain significance Single submitter
- CITED4 p.Pro104His Uncertain significance Single submitter
- CITED4 p.Pro110Ser Uncertain significance Single submitter
- CITED4 p.Pro113Ser Uncertain significance Single submitter
- CITED4 p.Pro17Leu Uncertain significance Single submitter
- CITED4 p.Pro18Arg Uncertain significance Single submitter
- CITED4 p.Pro33Leu Uncertain significance Single submitter
- CITED4 p.Pro50Leu Uncertain significance Single submitter
- CITED4 p.Pro54Leu Uncertain significance Single submitter
- CITED4 p.Pro59His Uncertain significance Single submitter
- CITED4 p.Ser181Tyr Uncertain significance Single submitter
All CITED4 variants
Likely benign 1
- p.Pro95Leu Single submitter
Uncertain significance 44
- p.Ala116Thr Single submitter ⚠
- p.Ala22Gly Single submitter ⚠
- p.Ala28Val Single submitter ⚠
- p.Ala93Glu Single submitter ⚠
- p.Arg155Cys Single submitter ⚠
- p.Arg155Gly Single submitter ⚠
- p.Arg30Gln Single submitter ⚠
- p.Arg30Trp Single submitter ⚠
- p.Arg57Gly Single submitter ⚠
- p.Asn105His Single submitter ⚠
- p.Asp172Glu Single submitter ⚠
- p.Asp3Gly Single submitter ⚠
- p.Gln114Pro Single submitter ⚠
- p.Glu148Asp Single submitter ⚠
- p.Glu159Lys Single submitter ⚠
- p.Gly25Cys Single submitter ⚠
- p.Gly25Val Single submitter ⚠
- p.His88Pro Single submitter ⚠
- p.Ile137Val Single submitter ⚠
- p.Ile86Val Single submitter ⚠
- p.Leu136Val Single submitter ⚠
- p.Leu29Phe Single submitter ⚠
- p.Phe67Leu Single submitter ⚠
- p.Pro104His Single submitter ⚠
- p.Pro110Ser Single submitter ⚠
- p.Pro113Ser Single submitter ⚠
- p.Pro17Leu Single submitter ⚠
- p.Pro18Arg Single submitter ⚠
- p.Pro33Leu Single submitter ⚠
- p.Pro46Leu Single submitter ⚠
- p.Pro50Leu Single submitter ⚠
- p.Pro54Leu Single submitter ⚠
- p.Pro59His Single submitter ⚠
- p.Pro80Ala Single submitter ⚠
- p.Pro82Ser Single submitter ⚠
- p.Pro95Arg Single submitter ⚠
- p.Pro97Arg Single submitter ⚠
- p.Ser175Pro Single submitter ⚠
- p.Ser181Tyr Single submitter ⚠
- p.Thr143Pro Single submitter ⚠
- p.Val14Gly Single submitter ⚠
- p.Val182Ala Single submitter ⚠
- p.Val182Gly Single submitter ⚠
- p.Val92Leu Single submitter ⚠