CKAP4 — 86 ClinVar variants
All ClinVar germline CKAP4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 76 flagged for review →
3 Benign · 8 Likely benign · 75 Uncertain significance
Full CKAP4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 76
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CKAP4 p.Ala167Gly Uncertain significance Single submitter
- CKAP4 p.Ala23Gly Uncertain significance Single submitter
- CKAP4 p.Ala449Thr Uncertain significance Single submitter
- CKAP4 p.Ala522Thr Uncertain significance Single submitter
- CKAP4 p.Arg447His Uncertain significance Single submitter
- CKAP4 p.Arg523His Uncertain significance Single submitter
- CKAP4 p.Arg590Thr Uncertain significance Single submitter
- CKAP4 p.Asn61His Uncertain significance Single submitter
- CKAP4 p.Asp250Asn Uncertain significance Single submitter
- CKAP4 p.Gln142Arg Uncertain significance Single submitter
- CKAP4 p.Gln504Arg Uncertain significance Single submitter
- CKAP4 p.Gln527Lys Uncertain significance Single submitter
- CKAP4 p.Glu20Asp Uncertain significance Single submitter
- CKAP4 p.Glu295Gln Uncertain significance Single submitter
- CKAP4 p.Glu369Gln Uncertain significance Single submitter
- CKAP4 p.Glu376Gln Uncertain significance Single submitter
- CKAP4 p.Gly419Ala Uncertain significance Single submitter
- CKAP4 p.Gly459Arg Uncertain significance Single submitter
- CKAP4 p.Gly579Asp Uncertain significance Single submitter
- CKAP4 p.His24Pro Uncertain significance Single submitter
- CKAP4 p.His395Arg Uncertain significance Single submitter
- CKAP4 p.His511Asp Uncertain significance Single submitter
- CKAP4 p.Ile370Ser Uncertain significance Single submitter
- CKAP4 p.Ile567Arg Uncertain significance Single submitter
- CKAP4 p.Lys213Arg Uncertain significance Single submitter
- CKAP4 p.Lys246Arg Uncertain significance Single submitter
- CKAP4 p.Met307Val Uncertain significance Single submitter
- CKAP4 p.Met317Thr Uncertain significance Single submitter
- CKAP4 p.Pro387Arg Uncertain significance Single submitter
- CKAP4 p.Pro43Gln Uncertain significance Single submitter
- CKAP4 p.Pro49Gln Uncertain significance Single submitter
- CKAP4 p.Ser195Arg Uncertain significance Single submitter
- CKAP4 p.Ser312Gly Uncertain significance Single submitter
- CKAP4 p.Ser84Ala Uncertain significance Single submitter
- CKAP4 p.Tyr483Cys Uncertain significance Single submitter
- CKAP4 p.Val363Ile Uncertain significance Single submitter
Predictors split 40
The independent predictors disagree with each other — read with care.
- CKAP4 p.Ala87Val Uncertain significance Single submitter
- CKAP4 p.Arg199Trp Uncertain significance Single submitter
- CKAP4 p.Arg326Cys Uncertain significance Single submitter
- CKAP4 p.Arg365Cys Uncertain significance Single submitter
- CKAP4 p.Arg365His Uncertain significance Single submitter
- CKAP4 p.Arg378Cys Uncertain significance Single submitter
- CKAP4 p.Arg378His Uncertain significance Single submitter
- CKAP4 p.Arg454Cys Uncertain significance Single submitter
- CKAP4 p.Arg454His Likely benign Single submitter
- CKAP4 p.Arg523Cys Uncertain significance Single submitter
- CKAP4 p.Asn538Ile Uncertain significance Single submitter
- CKAP4 p.Glu194Gly Uncertain significance Single submitter
- CKAP4 p.Glu196Lys Uncertain significance Single submitter
- CKAP4 p.Glu340Gly Uncertain significance Single submitter
- CKAP4 p.Glu360Lys Uncertain significance Single submitter
- CKAP4 p.Gly71Cys Uncertain significance Single submitter
- CKAP4 p.Gly72Ser Uncertain significance Single submitter
- CKAP4 p.His54Tyr Uncertain significance Single submitter
- CKAP4 p.Ile567Leu Uncertain significance Single submitter
- CKAP4 p.Leu357Phe Uncertain significance Single submitter
- CKAP4 p.Leu366Phe Uncertain significance Single submitter
- CKAP4 p.Lys440Glu Uncertain significance Single submitter
- CKAP4 p.Pro367Arg Uncertain significance Single submitter
- CKAP4 p.Pro367Leu Uncertain significance Single submitter
- CKAP4 p.Pro44Leu Uncertain significance Single submitter
- CKAP4 p.Pro51Ser Uncertain significance Single submitter
- CKAP4 p.Ser262Gly Uncertain significance Single submitter
- CKAP4 p.Ser359Cys Uncertain significance Single submitter
- CKAP4 p.Ser364Phe Uncertain significance Single submitter
- CKAP4 p.Ser534Tyr Uncertain significance Single submitter
- CKAP4 p.Ser83Phe Uncertain significance Single submitter
- CKAP4 p.Thr168Ile Uncertain significance Single submitter
- CKAP4 p.Thr231Met Uncertain significance Single submitter
- CKAP4 p.Thr344Met Uncertain significance Single submitter
- CKAP4 p.Thr353Met Uncertain significance Single submitter
- CKAP4 p.Thr478Ile Uncertain significance Single submitter
- CKAP4 p.Thr512Met Uncertain significance Single submitter
- CKAP4 p.Val130Asp Uncertain significance Single submitter
- CKAP4 p.Val137Asp Uncertain significance Single submitter
- CKAP4 p.Val416Met Uncertain significance Single submitter
All CKAP4 variants
Benign 3
- p.His444= Multiple submitters
- p.Leu580Val Multiple submitters
- p.Thr236= Multiple submitters
Likely benign 8
- p.Tyr483= Multiple submitters
- p.Arg394Lys Single submitter
- p.Arg454His Single submitter ⚠
- p.Gly386Arg Single submitter
- p.Gly73= Single submitter
- p.Ser140Gly Single submitter
- p.Ser382Ala Single submitter
- p.Val363Ala Single submitter
Uncertain significance 75
- p.Ala167Gly Single submitter ⚠
- p.Ala23Gly Single submitter ⚠
- p.Ala449Thr Single submitter ⚠
- p.Ala522Thr Single submitter ⚠
- p.Ala87Val Single submitter ⚠
- p.Arg199Trp Single submitter ⚠
- p.Arg326Cys Single submitter ⚠
- p.Arg365Cys Single submitter ⚠
- p.Arg365His Single submitter ⚠
- p.Arg378Cys Single submitter ⚠
- p.Arg378His Single submitter ⚠
- p.Arg447His Single submitter ⚠
- p.Arg454Cys Single submitter ⚠
- p.Arg523Cys Single submitter ⚠
- p.Arg523His Single submitter ⚠
- p.Arg590Thr Single submitter ⚠
- p.Asn538Ile Single submitter ⚠
- p.Asn61His Single submitter ⚠
- p.Asp250Asn Single submitter ⚠
- p.Gln142Arg Single submitter ⚠
- p.Gln504Arg Single submitter ⚠
- p.Gln527Lys Single submitter ⚠
- p.Glu194Gly Single submitter ⚠
- p.Glu196Lys Single submitter ⚠
- p.Glu20Asp Single submitter ⚠
- p.Glu295Gln Single submitter ⚠
- p.Glu340Gly Single submitter ⚠
- p.Glu360Lys Single submitter ⚠
- p.Glu369Gln Single submitter ⚠
- p.Glu376Gln Single submitter ⚠
- p.Gly419Ala Single submitter ⚠
- p.Gly459Arg Single submitter ⚠
- p.Gly579Asp Single submitter ⚠
- p.Gly71Cys Single submitter ⚠
- p.Gly72Ser Single submitter ⚠
- p.His24Pro Single submitter ⚠
- p.His395Arg Single submitter ⚠
- p.His511Asp Single submitter ⚠
- p.His54Tyr Single submitter ⚠
- p.Ile370Ser Single submitter ⚠
- p.Ile567Arg Single submitter ⚠
- p.Ile567Leu Single submitter ⚠
- p.Leu357Phe Single submitter ⚠
- p.Leu366Phe Single submitter ⚠
- p.Lys213Arg Single submitter ⚠
- p.Lys246Arg Single submitter ⚠
- p.Lys440Glu Single submitter ⚠
- p.Met307Val Single submitter ⚠
- p.Met317Thr Single submitter ⚠
- p.Pro367Arg Single submitter ⚠
- p.Pro367Leu Single submitter ⚠
- p.Pro387Arg Single submitter ⚠
- p.Pro43Gln Single submitter ⚠
- p.Pro44Leu Single submitter ⚠
- p.Pro49Gln Single submitter ⚠
- p.Pro51Ser Single submitter ⚠
- p.Ser195Arg Single submitter ⚠
- p.Ser262Gly Single submitter ⚠
- p.Ser312Gly Single submitter ⚠
- p.Ser359Cys Single submitter ⚠
- p.Ser364Phe Single submitter ⚠
- p.Ser534Tyr Single submitter ⚠
- p.Ser83Phe Single submitter ⚠
- p.Ser84Ala Single submitter ⚠
- p.Thr168Ile Single submitter ⚠
- p.Thr231Met Single submitter ⚠
- p.Thr344Met Single submitter ⚠
- p.Thr353Met Single submitter ⚠
- p.Thr478Ile Single submitter ⚠
- p.Thr512Met Single submitter ⚠
- p.Tyr483Cys Single submitter ⚠
- p.Val130Asp Single submitter ⚠
- p.Val137Asp Single submitter ⚠
- p.Val363Ile Single submitter ⚠
- p.Val416Met Single submitter ⚠