CKAP5 — 199 ClinVar variants
All ClinVar germline CKAP5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 189 flagged for review →
9 Likely benign · 190 Uncertain significance
Full CKAP5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 189
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 122
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CKAP5 p.Ala1099Thr Uncertain significance Single submitter
- CKAP5 p.Ala1127Thr Uncertain significance Single submitter
- CKAP5 p.Ala124Ser Uncertain significance Single submitter
- CKAP5 p.Ala124Thr Uncertain significance Single submitter
- CKAP5 p.Ala1429Gly Uncertain significance Single submitter
- CKAP5 p.Ala1429Val Uncertain significance Single submitter
- CKAP5 p.Ala1698Thr Uncertain significance Single submitter
- CKAP5 p.Ala1972Val Uncertain significance Single submitter
- CKAP5 p.Ala452Thr Uncertain significance Single submitter
- CKAP5 p.Ala509Thr Uncertain significance Single submitter
- CKAP5 p.Ala527Thr Uncertain significance Single submitter
- CKAP5 p.Ala763Ser Uncertain significance Single submitter
- CKAP5 p.Ala763Thr Uncertain significance Single submitter
- CKAP5 p.Ala819Val Uncertain significance Single submitter
- CKAP5 p.Ala963Thr Uncertain significance Single submitter
- CKAP5 p.Ala963Val Uncertain significance Single submitter
- CKAP5 p.Ala969Thr Uncertain significance Single submitter
- CKAP5 p.Arg1030Leu Uncertain significance Single submitter
- CKAP5 p.Arg1035Gln Uncertain significance Single submitter
- CKAP5 p.Arg1468Leu Uncertain significance Single submitter
- CKAP5 p.Arg1525Gln Uncertain significance Single submitter
- CKAP5 p.Arg1569Lys Uncertain significance Single submitter
- CKAP5 p.Arg1654Gly Uncertain significance Single submitter
- CKAP5 p.Arg1654Trp Uncertain significance Single submitter
- CKAP5 p.Arg1885Trp Uncertain significance Single submitter
- CKAP5 p.Arg1891Gly Uncertain significance Single submitter
- CKAP5 p.Arg908Gln Uncertain significance Single submitter
- CKAP5 p.Asn1314Ser Uncertain significance Single submitter
- CKAP5 p.Asn573Ser Uncertain significance Single submitter
- CKAP5 p.Asn846Asp Uncertain significance Single submitter
- CKAP5 p.Asn846Ser Uncertain significance Single submitter
- CKAP5 p.Asn941His Uncertain significance Single submitter
- CKAP5 p.Asn99Ser Uncertain significance Single submitter
- CKAP5 p.Asp1153Glu Uncertain significance Single submitter
- CKAP5 p.Asp1532Asn Uncertain significance Single submitter
- CKAP5 p.Asp806Gly Uncertain significance Single submitter
- CKAP5 p.Cys1113Arg Uncertain significance Single submitter
- CKAP5 p.Cys1113Tyr Uncertain significance Single submitter
- CKAP5 p.Cys1768Trp Uncertain significance Single submitter
- CKAP5 p.Gln235Pro Uncertain significance Single submitter
- CKAP5 p.Gln415Lys Uncertain significance Single submitter
- CKAP5 p.Gln895Lys Uncertain significance Single submitter
- CKAP5 p.Glu1609Lys Uncertain significance Single submitter
- CKAP5 p.Glu1656Lys Uncertain significance Single submitter
- CKAP5 p.Glu1746Asp Uncertain significance Single submitter
- CKAP5 p.Glu578Gln Uncertain significance Single submitter
- CKAP5 p.Glu708Lys Uncertain significance Single submitter
- CKAP5 p.Gly255Asp Uncertain significance Single submitter
- CKAP5 p.Gly886Ala Uncertain significance Single submitter
- CKAP5 p.Gly92Ser Uncertain significance Single submitter
- CKAP5 p.His1994Pro Uncertain significance Single submitter
- CKAP5 p.Ile110Val Uncertain significance Single submitter
- CKAP5 p.Ile141Met Uncertain significance Single submitter
- CKAP5 p.Ile1558Val Uncertain significance Single submitter
- CKAP5 p.Ile1611Met Uncertain significance Single submitter
- CKAP5 p.Ile1618Val Uncertain significance Single submitter
- CKAP5 p.Ile165Val Uncertain significance Single submitter
- CKAP5 p.Ile1820Thr Uncertain significance Single submitter
- CKAP5 p.Ile187Phe Uncertain significance Single submitter
- CKAP5 p.Ile366Val Uncertain significance Single submitter
- CKAP5 p.Ile388Val Uncertain significance Single submitter
- CKAP5 p.Ile420Val Uncertain significance Single submitter
- CKAP5 p.Ile582Val Uncertain significance Single submitter
- CKAP5 p.Ile664Thr Uncertain significance Single submitter
- CKAP5 p.Ile668Val Uncertain significance Single submitter
- CKAP5 p.Ile743Val Uncertain significance Single submitter
- CKAP5 p.Leu152Ser Uncertain significance Single submitter
- CKAP5 p.Leu1794Val Uncertain significance Single submitter
- CKAP5 p.Lys1704Arg Uncertain significance Single submitter
- CKAP5 p.Lys282Glu Uncertain significance Single submitter
- CKAP5 p.Lys371Arg Uncertain significance Single submitter
- CKAP5 p.Lys486Arg Uncertain significance Single submitter
- CKAP5 p.Lys55Glu Uncertain significance Single submitter
- CKAP5 p.Lys55Thr Uncertain significance Single submitter
- CKAP5 p.Met115Thr Uncertain significance Single submitter
- CKAP5 p.Met1172Leu Uncertain significance Single submitter
- CKAP5 p.Met1577Thr Uncertain significance Single submitter
- CKAP5 p.Met1577Val Uncertain significance Single submitter
- CKAP5 p.Met1802Thr Uncertain significance Single submitter
- CKAP5 p.Met722Val Uncertain significance Single submitter
- CKAP5 p.Met782Leu Uncertain significance Single submitter
- CKAP5 p.Phe1103Cys Uncertain significance Single submitter
- CKAP5 p.Phe231Cys Uncertain significance Single submitter
- CKAP5 p.Phe809Val Uncertain significance Single submitter
- CKAP5 p.Pro1100Ala Uncertain significance Single submitter
- CKAP5 p.Pro1130Ser Uncertain significance Single submitter
- CKAP5 p.Pro1431Ser Uncertain significance Single submitter
- CKAP5 p.Pro1958Arg Uncertain significance Single submitter
- CKAP5 p.Pro538Ala Uncertain significance Single submitter
- CKAP5 p.Pro542Leu Uncertain significance Single submitter
- CKAP5 p.Pro585Ala Uncertain significance Single submitter
- CKAP5 p.Ser1157Ala Uncertain significance Single submitter
- CKAP5 p.Ser1536Gly Uncertain significance Single submitter
- CKAP5 p.Ser2030Thr Uncertain significance Single submitter
- CKAP5 p.Ser524Leu Uncertain significance Single submitter
- CKAP5 p.Ser95Asn Uncertain significance Single submitter
- CKAP5 p.Thr1187Asn Uncertain significance Single submitter
- CKAP5 p.Thr1283Ser Uncertain significance Single submitter
- CKAP5 p.Thr1846Pro Uncertain significance Single submitter
- CKAP5 p.Thr1925Ala Uncertain significance Single submitter
- CKAP5 p.Thr1970Ala Uncertain significance Single submitter
- CKAP5 p.Thr223Ala Uncertain significance Single submitter
- CKAP5 p.Thr365Ala Uncertain significance Single submitter
- CKAP5 p.Thr416Ile Uncertain significance Single submitter
- CKAP5 p.Thr431Ala Uncertain significance Single submitter
- CKAP5 p.Thr569Ala Uncertain significance Single submitter
- CKAP5 p.Thr735Ser Uncertain significance Single submitter
- CKAP5 p.Thr903Ala Uncertain significance Single submitter
- CKAP5 p.Thr964Ile Uncertain significance Single submitter
- CKAP5 p.Tyr1024Phe Uncertain significance Single submitter
- CKAP5 p.Tyr116Asn Uncertain significance Single submitter
- CKAP5 p.Val1034Leu Uncertain significance Single submitter
- CKAP5 p.Val142Glu Uncertain significance Single submitter
- CKAP5 p.Val1498Ala Uncertain significance Single submitter
- CKAP5 p.Val1675Ile Uncertain significance Single submitter
- CKAP5 p.Val168Ala Uncertain significance Single submitter
- CKAP5 p.Val2008Gly Uncertain significance Single submitter
- CKAP5 p.Val305Ala Uncertain significance Single submitter
- CKAP5 p.Val781Met Uncertain significance Single submitter
- CKAP5 p.Val849Ile Uncertain significance Single submitter
- CKAP5 p.Val965Ala Uncertain significance Single submitter
-
CKAP5 p.Lys241Glu
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 67
The independent predictors disagree with each other — read with care.
- CKAP5 p.Ala1041Thr Uncertain significance Single submitter
- CKAP5 p.Ala1386Ser Uncertain significance Single submitter
- CKAP5 p.Ala188Val Uncertain significance Single submitter
- CKAP5 p.Ala240Thr Uncertain significance Single submitter
- CKAP5 p.Ala626Thr Uncertain significance Single submitter
- CKAP5 p.Ala699Thr Uncertain significance Single submitter
- CKAP5 p.Ala969Glu Uncertain significance Single submitter
- CKAP5 p.Arg1010Cys Uncertain significance Single submitter
- CKAP5 p.Arg1315Trp Uncertain significance Single submitter
- CKAP5 p.Arg1632Trp Uncertain significance Single submitter
- CKAP5 p.Arg1666Cys Uncertain significance Single submitter
- CKAP5 p.Arg1666His Uncertain significance Single submitter
- CKAP5 p.Arg233Cys Uncertain significance Single submitter
- CKAP5 p.Arg233His Uncertain significance Single submitter
- CKAP5 p.Asn99Tyr Uncertain significance Single submitter
- CKAP5 p.Asp1229Asn Uncertain significance Single submitter
- CKAP5 p.Asp2019Asn Uncertain significance Single submitter
- CKAP5 p.Asp631His Uncertain significance Single submitter
- CKAP5 p.Gln1218Leu Uncertain significance Single submitter
- CKAP5 p.Gln379Lys Uncertain significance Single submitter
- CKAP5 p.Glu111Val Uncertain significance Single submitter
- CKAP5 p.Glu1521Gly Uncertain significance Single submitter
- CKAP5 p.Glu1787Lys Uncertain significance Single submitter
- CKAP5 p.Glu584Asp Uncertain significance Single submitter
- CKAP5 p.Glu795Val Uncertain significance Single submitter
- CKAP5 p.Glu856Ala Uncertain significance Single submitter
- CKAP5 p.Glu856Gly Uncertain significance Single submitter
- CKAP5 p.Glu883Asp Uncertain significance Single submitter
- CKAP5 p.Gly1059Glu Uncertain significance Single submitter
- CKAP5 p.Gly92Val Uncertain significance Single submitter
- CKAP5 p.Ile112Val Uncertain significance Single submitter
- CKAP5 p.Ile119Thr Uncertain significance Single submitter
- CKAP5 p.Ile1390Val Uncertain significance Single submitter
- CKAP5 p.Ile1655Asn Uncertain significance Single submitter
- CKAP5 p.Ile307Met Uncertain significance Single submitter
- CKAP5 p.Ile706Met Uncertain significance Single submitter
- CKAP5 p.Ile805Met Uncertain significance Single submitter
- CKAP5 p.Leu1178Ser Uncertain significance Single submitter
- CKAP5 p.Leu280Ile Uncertain significance Single submitter
- CKAP5 p.Lys1121Arg Uncertain significance Single submitter
- CKAP5 p.Lys1128Arg Uncertain significance Single submitter
- CKAP5 p.Lys1433Glu Uncertain significance Single submitter
- CKAP5 p.Lys484Arg Uncertain significance Single submitter
- CKAP5 p.Lys491Asn Uncertain significance Single submitter
- CKAP5 p.Lys491Glu Uncertain significance Single submitter
- CKAP5 p.Lys503Arg Uncertain significance Single submitter
- CKAP5 p.Lys860Glu Uncertain significance Single submitter
- CKAP5 p.Met931Val Uncertain significance Single submitter
- CKAP5 p.Phe98Leu Uncertain significance Single submitter
- CKAP5 p.Pro1159Arg Uncertain significance Single submitter
- CKAP5 p.Pro1867Gln Uncertain significance Single submitter
- CKAP5 p.Pro364Arg Uncertain significance Single submitter
- CKAP5 p.Pro896Leu Uncertain significance Single submitter
- CKAP5 p.Ser1695Arg Uncertain significance Single submitter
- CKAP5 p.Ser1961Phe Uncertain significance Single submitter
- CKAP5 p.Ser2030Cys Uncertain significance Single submitter
- CKAP5 p.Thr1008Ile Uncertain significance Single submitter
- CKAP5 p.Thr1014Ile Uncertain significance Single submitter
- CKAP5 p.Thr1148Ile Uncertain significance Single submitter
- CKAP5 p.Thr345Asn Uncertain significance Single submitter
- CKAP5 p.Thr431Ile Uncertain significance Single submitter
- CKAP5 p.Thr773Ile Uncertain significance Single submitter
- CKAP5 p.Thr86Ile Uncertain significance Single submitter
- CKAP5 p.Val1638Ile Uncertain significance Single submitter
- CKAP5 p.Val1912Met Uncertain significance Single submitter
- CKAP5 p.Val482Ala Uncertain significance Single submitter
- CKAP5 p.Val884Ala Uncertain significance Single submitter
All CKAP5 variants
Likely benign 9
- p.Ala566Thr Single submitter
- p.Asn1444Ser Single submitter
- p.Asn1786= Single submitter
- p.Ile1432Val Single submitter
- p.Leu1719= Single submitter
- p.Leu211= Single submitter
- p.Lys1077= Single submitter
- p.Ser984= Single submitter
- p.Thr1780= Single submitter
Uncertain significance 190
- p.Ala1041Thr Single submitter ⚠
- p.Ala1099Thr Single submitter ⚠
- p.Ala1127Thr Single submitter ⚠
- p.Ala124Ser Single submitter ⚠
- p.Ala124Thr Single submitter ⚠
- p.Ala1386Ser Single submitter ⚠
- p.Ala1429Gly Single submitter ⚠
- p.Ala1429Val Single submitter ⚠
- p.Ala1698Thr Single submitter ⚠
- p.Ala188Val Single submitter ⚠
- p.Ala1972Val Single submitter ⚠
- p.Ala240Thr Single submitter ⚠
- p.Ala452Thr Single submitter ⚠
- p.Ala509Thr Single submitter ⚠
- p.Ala527Thr Single submitter ⚠
- p.Ala626Thr Single submitter ⚠
- p.Ala699Thr Single submitter ⚠
- p.Ala763Ser Single submitter ⚠
- p.Ala763Thr Single submitter ⚠
- p.Ala819Val Single submitter ⚠
- p.Ala963Thr Single submitter ⚠
- p.Ala963Val Single submitter ⚠
- p.Ala969Glu Single submitter ⚠
- p.Ala969Thr Single submitter ⚠
- p.Arg1010Cys Single submitter ⚠
- p.Arg1030Leu Single submitter ⚠
- p.Arg1035Gln Single submitter ⚠
- p.Arg1315Trp Single submitter ⚠
- p.Arg1468Leu Single submitter ⚠
- p.Arg1525Gln Single submitter ⚠
- p.Arg1569Lys Single submitter ⚠
- p.Arg1632Trp Single submitter ⚠
- p.Arg1654Gly Single submitter ⚠
- p.Arg1654Trp Single submitter ⚠
- p.Arg1666Cys Single submitter ⚠
- p.Arg1666His Single submitter ⚠
- p.Arg1885Trp Single submitter ⚠
- p.Arg1891Gly Single submitter ⚠
- p.Arg233Cys Single submitter ⚠
- p.Arg233His Single submitter ⚠
- p.Arg908Gln Single submitter ⚠
- p.Asn1314Ser Single submitter ⚠
- p.Asn573Ser Single submitter ⚠
- p.Asn846Asp Single submitter ⚠
- p.Asn846Ser Single submitter ⚠
- p.Asn941His Single submitter ⚠
- p.Asn99Ser Single submitter ⚠
- p.Asn99Tyr Single submitter ⚠
- p.Asp1153Glu Single submitter ⚠
- p.Asp1229Asn Single submitter ⚠
- p.Asp1532Asn Single submitter ⚠
- p.Asp2019Asn Single submitter ⚠
- p.Asp631His Single submitter ⚠
- p.Asp806Gly Single submitter ⚠
- p.Cys1113Arg Single submitter ⚠
- p.Cys1113Tyr Single submitter ⚠
- p.Cys1768Trp Single submitter ⚠
- p.Gln1218Leu Single submitter ⚠
- p.Gln235Pro Single submitter ⚠
- p.Gln379Lys Single submitter ⚠
- p.Gln415Lys Single submitter ⚠
- p.Gln895Lys Single submitter ⚠
- p.Glu111Val Single submitter ⚠
- p.Glu1521Gly Single submitter ⚠
- p.Glu1609Lys Single submitter ⚠
- p.Glu1656Lys Single submitter ⚠
- p.Glu1746Asp Single submitter ⚠
- p.Glu1787Lys Single submitter ⚠
- p.Glu578Gln Single submitter ⚠
- p.Glu584Asp Single submitter ⚠
- p.Glu708Lys Single submitter ⚠
- p.Glu795Val Single submitter ⚠
- p.Glu856Ala Single submitter ⚠
- p.Glu856Gly Single submitter ⚠
- p.Glu883Asp Single submitter ⚠
- p.Gly1059Glu Single submitter ⚠
- p.Gly255Asp Single submitter ⚠
- p.Gly886Ala Single submitter ⚠
- p.Gly92Ser Single submitter ⚠
- p.Gly92Val Single submitter ⚠
- p.His1994Pro Single submitter ⚠
- p.Ile110Val Single submitter ⚠
- p.Ile112Val Single submitter ⚠
- p.Ile119Thr Single submitter ⚠
- p.Ile1390Val Single submitter ⚠
- p.Ile141Met Single submitter ⚠
- p.Ile1558Val Single submitter ⚠
- p.Ile1611Met Single submitter ⚠
- p.Ile1618Val Single submitter ⚠
- p.Ile1655Asn Single submitter ⚠
- p.Ile165Val Single submitter ⚠
- p.Ile1820Thr Single submitter ⚠
- p.Ile187Phe Single submitter ⚠
- p.Ile307Met Single submitter ⚠
- p.Ile366Val Single submitter ⚠
- p.Ile388Val Single submitter ⚠
- p.Ile420Val Single submitter ⚠
- p.Ile582Val Single submitter ⚠
- p.Ile664Thr Single submitter ⚠
- p.Ile668Val Single submitter ⚠
- p.Ile706Met Single submitter ⚠
- p.Ile743Val Single submitter ⚠
- p.Ile805Met Single submitter ⚠
- p.Leu1178Ser Single submitter ⚠
- p.Leu152Ser Single submitter ⚠
- p.Leu1794Val Single submitter ⚠
- p.Leu280Ile Single submitter ⚠
- p.Lys1121Arg Single submitter ⚠
- p.Lys1128Arg Single submitter ⚠
- p.Lys1433Glu Single submitter ⚠
- p.Lys1704Arg Single submitter ⚠
- p.Lys282Glu Single submitter ⚠
- p.Lys371Arg Single submitter ⚠
- p.Lys484Arg Single submitter ⚠
- p.Lys486Arg Single submitter ⚠
- p.Lys491Asn Single submitter ⚠
- p.Lys491Glu Single submitter ⚠
- p.Lys503Arg Single submitter ⚠
- p.Lys55Glu Single submitter ⚠
- p.Lys55Thr Single submitter ⚠
- p.Lys860Glu Single submitter ⚠
- p.Met115Thr Single submitter ⚠
- p.Met1172Leu Single submitter ⚠
- p.Met1577Thr Single submitter ⚠
- p.Met1577Val Single submitter ⚠
- p.Met1802Thr Single submitter ⚠
- p.Met722Val Single submitter ⚠
- p.Met782Leu Single submitter ⚠
- p.Met931Val Single submitter ⚠
- p.Phe1103Cys Single submitter ⚠
- p.Phe231Cys Single submitter ⚠
- p.Phe809Val Single submitter ⚠
- p.Phe98Leu Single submitter ⚠
- p.Pro1100Ala Single submitter ⚠
- p.Pro1130Ser Single submitter ⚠
- p.Pro1159Arg Single submitter ⚠
- p.Pro1431Ser Single submitter ⚠
- p.Pro1867Gln Single submitter ⚠
- p.Pro1958Arg Single submitter ⚠
- p.Pro364Arg Single submitter ⚠
- p.Pro538Ala Single submitter ⚠
- p.Pro542Leu Single submitter ⚠
- p.Pro585Ala Single submitter ⚠
- p.Pro896Leu Single submitter ⚠
- p.Ser1157Ala Single submitter ⚠
- p.Ser1536Gly Single submitter ⚠
- p.Ser1695Arg Single submitter ⚠
- p.Ser1961Phe Single submitter ⚠
- p.Ser2030Cys Single submitter ⚠
- p.Ser2030Thr Single submitter ⚠
- p.Ser524Leu Single submitter ⚠
- p.Ser95Asn Single submitter ⚠
- p.Ser95fs Single submitter
- p.Thr1008Ile Single submitter ⚠
- p.Thr1014Ile Single submitter ⚠
- p.Thr1148Ile Single submitter ⚠
- p.Thr1187Asn Single submitter ⚠
- p.Thr1283Ser Single submitter ⚠
- p.Thr1846Pro Single submitter ⚠
- p.Thr1925Ala Single submitter ⚠
- p.Thr1970Ala Single submitter ⚠
- p.Thr223Ala Single submitter ⚠
- p.Thr345Asn Single submitter ⚠
- p.Thr365Ala Single submitter ⚠
- p.Thr416Ile Single submitter ⚠
- p.Thr431Ala Single submitter ⚠
- p.Thr431Ile Single submitter ⚠
- p.Thr569Ala Single submitter ⚠
- p.Thr735Ser Single submitter ⚠
- p.Thr773Ile Single submitter ⚠
- p.Thr86Ile Single submitter ⚠
- p.Thr903Ala Single submitter ⚠
- p.Thr964Ile Single submitter ⚠
- p.Tyr1024Phe Single submitter ⚠
- p.Tyr116Asn Single submitter ⚠
- p.Val1034Leu Single submitter ⚠
- p.Val142Glu Single submitter ⚠
- p.Val1498Ala Single submitter ⚠
- p.Val1638Ile Single submitter ⚠
- p.Val1675Ile Single submitter ⚠
- p.Val168Ala Single submitter ⚠
- p.Val1912Met Single submitter ⚠
- p.Val2008Gly Single submitter ⚠
- p.Val305Ala Single submitter ⚠
- p.Val482Ala Single submitter ⚠
- p.Val781Met Single submitter ⚠
- p.Val849Ile Single submitter ⚠
- p.Val884Ala Single submitter ⚠
- p.Val965Ala Single submitter ⚠
- p.Lys241Glu No assertion criteria prostate cancer ⚠