CLASP2 — 140 ClinVar variants
All ClinVar germline CLASP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 84 flagged for review →
11 Benign · 16 Likely benign · 113 Uncertain significance
Full CLASP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 84
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLASP2 p.Ala1209Gly Uncertain significance Single submitter
- CLASP2 p.Ala1402Val Uncertain significance Single submitter
- CLASP2 p.Ala1496Pro Uncertain significance Single submitter
- CLASP2 p.Ala548Val Uncertain significance Single submitter
- CLASP2 p.Ala747Val Uncertain significance Single submitter
- CLASP2 p.Arg1166His Uncertain significance Single submitter
- CLASP2 p.Arg1227His Uncertain significance Single submitter
- CLASP2 p.Arg873Ser Uncertain significance Single submitter
- CLASP2 p.Asn1407Ile Uncertain significance Single submitter
- CLASP2 p.Asn987Ser Uncertain significance Single submitter
- CLASP2 p.Asp1081Val Uncertain significance Single submitter
- CLASP2 p.Asp1170Asn Uncertain significance Single submitter
- CLASP2 p.Asp1183Glu Uncertain significance Single submitter
- CLASP2 p.Asp1185Asn Uncertain significance Single submitter
- CLASP2 p.Asp1230Gly Uncertain significance Single submitter
- CLASP2 p.Asp1403Gly Uncertain significance Single submitter
- CLASP2 p.Asp243Val Uncertain significance Single submitter
- CLASP2 p.Glu246Asp Uncertain significance Single submitter
- CLASP2 p.Gly1184Ser Uncertain significance Single submitter
- CLASP2 p.Gly520Asp Uncertain significance Single submitter
- CLASP2 p.Gly631Ser Uncertain significance Single submitter
- CLASP2 p.Ile988Val Uncertain significance Single submitter
- CLASP2 p.Leu1210Phe Uncertain significance Single submitter
- CLASP2 p.Lys819Arg Uncertain significance Single submitter
- CLASP2 p.Met1070Val Uncertain significance Single submitter
- CLASP2 p.Met1479Val Uncertain significance Single submitter
- CLASP2 p.Met669Val Uncertain significance Single submitter
- CLASP2 p.Phe1305Cys Uncertain significance Single submitter
- CLASP2 p.Pro1191Leu Uncertain significance Single submitter
- CLASP2 p.Pro1196Ser Uncertain significance Single submitter
- CLASP2 p.Pro1226Ala Uncertain significance Single submitter
- CLASP2 p.Pro1226Leu Uncertain significance Single submitter
- CLASP2 p.Pro918Leu Uncertain significance Single submitter
- CLASP2 p.Ser1225Thr Uncertain significance Single submitter
- CLASP2 p.Ser1239Gly Uncertain significance Single submitter
- CLASP2 p.Ser274Gly Uncertain significance Single submitter
- CLASP2 p.Ser766Ile Uncertain significance Single submitter
- CLASP2 p.Thr1491Ala Uncertain significance Single submitter
- CLASP2 p.Thr478Ile Uncertain significance Single submitter
- CLASP2 p.Trp879Arg Uncertain significance Single submitter
- CLASP2 p.Tyr638Cys Uncertain significance Single submitter
- CLASP2 p.Val1381Leu Uncertain significance Single submitter
- CLASP2 p.Val487Ile Uncertain significance Single submitter
- CLASP2 p.Val810Met Uncertain significance Single submitter
Predictors split 40
The independent predictors disagree with each other — read with care.
- CLASP2 p.Ala1251Pro Uncertain significance Single submitter
- CLASP2 p.Ala408Ser Uncertain significance Single submitter
- CLASP2 p.Ala841Thr Uncertain significance Single submitter
- CLASP2 p.Arg566Cys Uncertain significance Single submitter
- CLASP2 p.Arg602Gln Uncertain significance Single submitter
- CLASP2 p.Arg624Gln Likely benign Single submitter
- CLASP2 p.Arg751His Uncertain significance Single submitter
- CLASP2 p.Arg802Gln Uncertain significance Single submitter
- CLASP2 p.Asn1483Thr Uncertain significance Single submitter
- CLASP2 p.Asp1465Asn Uncertain significance Single submitter
- CLASP2 p.Cys735Gly Uncertain significance Single submitter
- CLASP2 p.Gln1168His Uncertain significance Single submitter
- CLASP2 p.Glu1062Asp Uncertain significance Single submitter
- CLASP2 p.Glu1169Lys Uncertain significance Single submitter
- CLASP2 p.Glu475Lys Uncertain significance Single submitter
- CLASP2 p.Gly582Glu Uncertain significance Single submitter
- CLASP2 p.Gly629Asp Uncertain significance Single submitter
- CLASP2 p.Ile1012Val Uncertain significance Single submitter
- CLASP2 p.Ile438Val Uncertain significance Single submitter
- CLASP2 p.Leu1467Val Uncertain significance Single submitter
- CLASP2 p.Leu782Phe Uncertain significance Single submitter
- CLASP2 p.Lys1423Glu Uncertain significance Single submitter
- CLASP2 p.Met1297Thr Uncertain significance Single submitter
- CLASP2 p.Pro1388Ser Uncertain significance Single submitter
- CLASP2 p.Ser1055Leu Uncertain significance Single submitter
- CLASP2 p.Ser1059Leu Uncertain significance Single submitter
- CLASP2 p.Ser1228Phe Uncertain significance Single submitter
- CLASP2 p.Ser676Phe Uncertain significance Single submitter
- CLASP2 p.Ser778Pro Uncertain significance Single submitter
- CLASP2 p.Ser795Leu Uncertain significance Single submitter
- CLASP2 p.Thr1094Ala Uncertain significance Single submitter
- CLASP2 p.Thr478Ser Uncertain significance Single submitter
- CLASP2 p.Tyr1234Cys Uncertain significance Single submitter
- CLASP2 p.Tyr786Cys Uncertain significance Single submitter
- CLASP2 p.Tyr829Cys Uncertain significance Single submitter
- CLASP2 p.Tyr850Cys Uncertain significance Single submitter
- CLASP2 p.Val607Leu Uncertain significance Single submitter
- CLASP2 p.Val607Met Uncertain significance Single submitter
- CLASP2 p.Val965Ile Uncertain significance Single submitter
- CLASP2 p.Val975Phe Uncertain significance Single submitter
All CLASP2 variants
Benign 11
- c.1949-9C>T Multiple submitters
- p.Gly57= Multiple submitters
- p.Ser544= Multiple submitters
- p.Arg600= Single submitter
- p.Gly210Glu Single submitter
- c.2455-1147C>G No assertion criteria CLASP2-related disorder
- p.Ala1461= No assertion criteria CLASP2-related disorder
- p.Leu163Pro No assertion criteria CLASP2-related disorder
- p.Pro170= No assertion criteria CLASP2-related disorder
- p.Thr1107Ile No assertion criteria CLASP2-related disorder
- p.Tyr1294Cys No assertion criteria CLASP2-related disorder
Likely benign 16
- c.275-10C>T Single submitter
- p.Arg624Gln Single submitter ⚠
- p.Asp500= Single submitter
- p.Glu1419= Single submitter
- p.Ser795= Single submitter
- c.1527-6dup No assertion criteria CLASP2-related disorder
- c.1694+8C>T No assertion criteria CLASP2-related disorder
- c.-20GCGG[4] No assertion criteria CLASP2-related disorder
- p.Asn872= No assertion criteria CLASP2-related disorder
- p.Asp1262= No assertion criteria CLASP2-related disorder
- p.Asp1442= No assertion criteria CLASP2-related disorder
- p.Glu2= No assertion criteria CLASP2-related disorder
- p.Gly1192= No assertion criteria CLASP2-related disorder
- p.Gly230= No assertion criteria CLASP2-related disorder
- p.Ile447= No assertion criteria CLASP2-related disorder
- p.Thr1127= No assertion criteria CLASP2-related disorder
Uncertain significance 113
- c.2455-1137A>C Single submitter
- p.Ala1209Gly Single submitter ⚠
- p.Ala1251Pro Single submitter ⚠
- p.Ala1402Val Single submitter ⚠
- p.Ala1496Pro Single submitter ⚠
- p.Ala408Ser Single submitter ⚠
- p.Ala548Val Single submitter ⚠
- p.Ala747Val Single submitter ⚠
- p.Ala841Thr Single submitter ⚠
- p.Arg108Gln Single submitter
- p.Arg1166His Single submitter ⚠
- p.Arg1227His Single submitter ⚠
- p.Arg142Gln Single submitter
- p.Arg47Ser Single submitter
- p.Arg566Cys Single submitter ⚠
- p.Arg602Gln Single submitter ⚠
- p.Arg751His Single submitter ⚠
- p.Arg802Gln Single submitter ⚠
- p.Arg84Pro Single submitter
- p.Arg873Ser Single submitter ⚠
- p.Asn1407Ile Single submitter ⚠
- p.Asn1483Thr Single submitter ⚠
- p.Asn987Ser Single submitter ⚠
- p.Asp1081Val Single submitter ⚠
- p.Asp1170Asn Single submitter ⚠
- p.Asp1183Glu Single submitter ⚠
- p.Asp1185Asn Single submitter ⚠
- p.Asp1230Gly Single submitter ⚠
- p.Asp1403Gly Single submitter ⚠
- p.Asp1465Asn Single submitter ⚠
- p.Asp17Gly Single submitter
- p.Asp205Glu Single submitter
- p.Asp243Val Single submitter ⚠
- p.Asp98Tyr Single submitter
- p.Cys735Gly Single submitter ⚠
- p.Gln1168His Single submitter ⚠
- p.Gln12Lys Single submitter
- p.Gln161His Single submitter
- p.Glu1062Asp Single submitter ⚠
- p.Glu1169Lys Single submitter ⚠
- p.Glu246Asp Single submitter ⚠
- p.Glu475Lys Single submitter ⚠
- p.Gly1184Ser Single submitter ⚠
- p.Gly19Asp Single submitter
- p.Gly36Cys Single submitter
- p.Gly520Asp Single submitter ⚠
- p.Gly582Glu Single submitter ⚠
- p.Gly60Cys Single submitter
- p.Gly629Asp Single submitter ⚠
- p.Gly631Ser Single submitter ⚠
- p.His138Tyr Single submitter
- p.Ile1012Val Single submitter ⚠
- p.Ile115Thr Single submitter
- p.Ile191Met Single submitter
- p.Ile191Thr Single submitter
- p.Ile438Val Single submitter ⚠
- p.Ile73Val Single submitter
- p.Ile988Val Single submitter ⚠
- p.Leu1210Phe Single submitter ⚠
- p.Leu1467Val Single submitter ⚠
- p.Leu149Val Single submitter
- p.Leu28Phe Single submitter
- p.Leu782Phe Single submitter ⚠
- p.Lys1423Glu Single submitter ⚠
- p.Lys819Arg Single submitter ⚠
- p.Met1070Val Single submitter ⚠
- p.Met119Ile Single submitter
- p.Met1297Thr Single submitter ⚠
- p.Met1479Val Single submitter ⚠
- p.Met232Ile Single submitter
- p.Met669Val Single submitter ⚠
- p.Phe1305Cys Single submitter ⚠
- p.Phe141Leu Single submitter
- p.Phe176Leu Single submitter
- p.Pro1191Leu Single submitter ⚠
- p.Pro1196Ser Single submitter ⚠
- p.Pro1226Ala Single submitter ⚠
- p.Pro1226Leu Single submitter ⚠
- p.Pro1388Ser Single submitter ⚠
- p.Pro918Leu Single submitter ⚠
- p.Ser1055Leu Single submitter ⚠
- p.Ser1059Leu Single submitter ⚠
- p.Ser1225Thr Single submitter ⚠
- p.Ser1228Phe Single submitter ⚠
- p.Ser1239Gly Single submitter ⚠
- p.Ser274Gly Single submitter ⚠
- p.Ser5Ile Single submitter
- p.Ser676Phe Single submitter ⚠
- p.Ser766Ile Single submitter ⚠
- p.Ser778Pro Single submitter ⚠
- p.Ser795Leu Single submitter ⚠
- p.Thr1094Ala Single submitter ⚠
- p.Thr1491Ala Single submitter ⚠
- p.Thr478Ile Single submitter ⚠
- p.Thr478Ser Single submitter ⚠
- p.Trp879Arg Single submitter ⚠
- p.Tyr1234Cys Single submitter ⚠
- p.Tyr31Cys Single submitter
- p.Tyr638Cys Single submitter ⚠
- p.Tyr786Cys Single submitter ⚠
- p.Tyr829Cys Single submitter ⚠
- p.Tyr850Cys Single submitter ⚠
- p.Tyr88Cys Single submitter
- p.Val1381Leu Single submitter ⚠
- p.Val13Met Single submitter
- p.Val202Glu Single submitter
- p.Val487Ile Single submitter ⚠
- p.Val607Leu Single submitter ⚠
- p.Val607Met Single submitter ⚠
- p.Val810Met Single submitter ⚠
- p.Val965Ile Single submitter ⚠
- p.Val975Phe Single submitter ⚠
- c.2240-4C>G No assertion criteria CLASP2-related disorder