CLC — 12 ClinVar variants
All ClinVar germline CLC variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 12 flagged for review →
2 Benign · 10 Uncertain significance
Full CLC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 12
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 7
The independent predictors disagree with each other — read with care.
- CLC p.Asn65Lys Benign Multiple submitters
- CLC p.Asn105Ser Uncertain significance Single submitter
- CLC p.Gly24Ala Uncertain significance Single submitter
- CLC p.Leu91Pro Uncertain significance Single submitter
- CLC p.Met81Arg Uncertain significance Single submitter
- CLC p.Val102Leu Uncertain significance Single submitter
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CLC p.Ile130Ser
Benign
No assertion criteria
Abnormality of neuronal migration
All CLC variants
Benign 2
- p.Asn65Lys Multiple submitters ⚠
- p.Ile130Ser No assertion criteria Abnormality of neuronal migration ⚠
Uncertain significance 10
- p.Ala12Ser Single submitter ⚠
- p.Arg25Gln Single submitter ⚠
- p.Arg60His Single submitter ⚠
- p.Asn105Ser Single submitter ⚠
- p.Asp85Val Single submitter ⚠
- p.Gly24Ala Single submitter ⚠
- p.His41Tyr Single submitter ⚠
- p.Leu91Pro Single submitter ⚠
- p.Met81Arg Single submitter ⚠
- p.Val102Leu Single submitter ⚠