CLCA1 — 115 ClinVar variants
All ClinVar germline CLCA1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 93 flagged for review →
5 Benign · 11 Likely benign · 99 Uncertain significance
Full CLCA1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 93
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 83
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLCA1 p.Ala189Pro Uncertain significance Single submitter
- CLCA1 p.Ala436Thr Uncertain significance Single submitter
- CLCA1 p.Ala441Val Uncertain significance Single submitter
- CLCA1 p.Ala442Ser Uncertain significance Single submitter
- CLCA1 p.Ala570Val Uncertain significance Single submitter
- CLCA1 p.Ala583Val Uncertain significance Single submitter
- CLCA1 p.Ala618Thr Uncertain significance Single submitter
- CLCA1 p.Arg209Ile Uncertain significance Single submitter
- CLCA1 p.Arg322Cys Uncertain significance Single submitter
- CLCA1 p.Arg485Cys Uncertain significance Single submitter
- CLCA1 p.Arg582His Uncertain significance Single submitter
- CLCA1 p.Arg623Lys Uncertain significance Single submitter
- CLCA1 p.Arg686Pro Uncertain significance Single submitter
- CLCA1 p.Asn29His Uncertain significance Single submitter
- CLCA1 p.Asn416Ser Uncertain significance Single submitter
- CLCA1 p.Asp244Gly Uncertain significance Single submitter
- CLCA1 p.Asp412Val Uncertain significance Single submitter
- CLCA1 p.Asp654Glu Uncertain significance Single submitter
- CLCA1 p.Asp720Ala Uncertain significance Single submitter
- CLCA1 p.Asp851Tyr Uncertain significance Single submitter
- CLCA1 p.Cys308Phe Uncertain significance Single submitter
- CLCA1 p.Cys884Arg Uncertain significance Single submitter
- CLCA1 p.Gln150Lys Uncertain significance Single submitter
- CLCA1 p.Gln554Lys Uncertain significance Single submitter
- CLCA1 p.Gln708Arg Uncertain significance Single submitter
- CLCA1 p.Gln808Leu Uncertain significance Single submitter
- CLCA1 p.Gln869Arg Uncertain significance Single submitter
- CLCA1 p.Glu130Lys Uncertain significance Single submitter
- CLCA1 p.Glu446Gly Uncertain significance Single submitter
- CLCA1 p.Glu805Lys Uncertain significance Single submitter
- CLCA1 p.Gly113Asp Uncertain significance Single submitter
- CLCA1 p.Gly180Glu Uncertain significance Single submitter
- CLCA1 p.Gly454Arg Uncertain significance Single submitter
- CLCA1 p.Gly480Ala Uncertain significance Single submitter
- CLCA1 p.Gly540Ala Uncertain significance Single submitter
- CLCA1 p.Gly562Asp Uncertain significance Single submitter
- CLCA1 p.Gly765Arg Uncertain significance Single submitter
- CLCA1 p.Gly783Arg Uncertain significance Single submitter
- CLCA1 p.His242Gln Uncertain significance Single submitter
- CLCA1 p.Ile385Val Uncertain significance Single submitter
- CLCA1 p.Ile396Leu Uncertain significance Single submitter
- CLCA1 p.Ile698Val Uncertain significance Single submitter
- CLCA1 p.Ile901Phe Uncertain significance Single submitter
- CLCA1 p.Leu144Phe Uncertain significance Single submitter
- CLCA1 p.Leu323Pro Uncertain significance Single submitter
- CLCA1 p.Leu334Val Uncertain significance Single submitter
- CLCA1 p.Leu455Val Uncertain significance Single submitter
- CLCA1 p.Leu553Phe Uncertain significance Single submitter
- CLCA1 p.Leu909Arg Uncertain significance Single submitter
- CLCA1 p.Lys596Arg Uncertain significance Single submitter
- CLCA1 p.Lys596Gln Uncertain significance Single submitter
- CLCA1 p.Lys5Asn Uncertain significance Single submitter
- CLCA1 p.Lys760Arg Uncertain significance Single submitter
- CLCA1 p.Lys760Asn Uncertain significance Single submitter
- CLCA1 p.Lys760Gln Uncertain significance Single submitter
- CLCA1 p.Met56Val Uncertain significance Single submitter
- CLCA1 p.Pro112Leu Uncertain significance Single submitter
- CLCA1 p.Pro526Leu Uncertain significance Single submitter
- CLCA1 p.Pro607Ser Uncertain significance Single submitter
- CLCA1 p.Pro690Leu Uncertain significance Single submitter
- CLCA1 p.Pro690Thr Uncertain significance Single submitter
- CLCA1 p.Pro714Ala Uncertain significance Single submitter
- CLCA1 p.Pro867Leu Uncertain significance Single submitter
- CLCA1 p.Ser391Leu Uncertain significance Single submitter
- CLCA1 p.Ser602Asn Uncertain significance Single submitter
- CLCA1 p.Ser625Gly Uncertain significance Single submitter
- CLCA1 p.Ser821Thr Uncertain significance Single submitter
- CLCA1 p.Ser912Pro Uncertain significance Single submitter
- CLCA1 p.Thr207Ile Uncertain significance Single submitter
- CLCA1 p.Thr207Ser Uncertain significance Single submitter
- CLCA1 p.Thr232Met Uncertain significance Single submitter
- CLCA1 p.Thr251Lys Uncertain significance Single submitter
- CLCA1 p.Thr296Ile Uncertain significance Single submitter
- CLCA1 p.Thr402Asn Uncertain significance Single submitter
- CLCA1 p.Thr411Met Uncertain significance Single submitter
- CLCA1 p.Thr880Met Uncertain significance Single submitter
- CLCA1 p.Val425Ile Uncertain significance Single submitter
- CLCA1 p.Val506Glu Uncertain significance Single submitter
- CLCA1 p.Val508Met Uncertain significance Single submitter
- CLCA1 p.Val543Leu Uncertain significance Single submitter
- CLCA1 p.Val579Ile Uncertain significance Single submitter
- CLCA1 p.Val824Ile Uncertain significance Single submitter
- CLCA1 p.Val862Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- CLCA1 p.Tyr661His Benign Multiple submitters
- CLCA1 p.Ala677Asp Uncertain significance Single submitter
- CLCA1 p.Ala739Thr Uncertain significance Single submitter
- CLCA1 p.Gln845His Uncertain significance Single submitter
- CLCA1 p.Phe166Leu Uncertain significance Single submitter
- CLCA1 p.Pro117Ser Uncertain significance Single submitter
- CLCA1 p.Pro260Gln Uncertain significance Single submitter
- CLCA1 p.Ser405Pro Uncertain significance Single submitter
- CLCA1 p.Thr348Ile Uncertain significance Single submitter
- CLCA1 p.Val307Ala Uncertain significance Single submitter
All CLCA1 variants
Benign 5
- c.2113+8A>G Multiple submitters
- p.Asn682Lys Multiple submitters
- p.Tyr661His Multiple submitters ⚠
- p.Val609Ile Multiple submitters
- p.Thr637Ile Single submitter
Likely benign 11
- p.Arg390Gln Single submitter
- p.Arg686Gln Single submitter
- p.Arg861Gln Single submitter
- p.Asn886Asp Single submitter
- p.Gln869Glu Single submitter
- p.Gly766Asp Single submitter
- p.His764Gln Single submitter
- p.Ile360Val Single submitter
- p.Leu807Val Single submitter
- p.Thr597Met Single submitter
- p.Val37Ile Single submitter
Uncertain significance 99
- p.Ala189Pro Single submitter ⚠
- p.Ala436Thr Single submitter ⚠
- p.Ala441Val Single submitter ⚠
- p.Ala442Ser Single submitter ⚠
- p.Ala559Val Single submitter
- p.Ala570Val Single submitter ⚠
- p.Ala583Val Single submitter ⚠
- p.Ala618Thr Single submitter ⚠
- p.Ala677Asp Single submitter ⚠
- p.Ala739Thr Single submitter ⚠
- p.Arg209Ile Single submitter ⚠
- p.Arg322Cys Single submitter ⚠
- p.Arg322His Single submitter
- p.Arg485Cys Single submitter ⚠
- p.Arg582His Single submitter ⚠
- p.Arg623Lys Single submitter ⚠
- p.Arg686Pro Single submitter ⚠
- p.Asn29His Single submitter ⚠
- p.Asn416Ser Single submitter ⚠
- p.Asp244Gly Single submitter ⚠
- p.Asp412Val Single submitter ⚠
- p.Asp654Glu Single submitter ⚠
- p.Asp720Ala Single submitter ⚠
- p.Asp749Tyr Single submitter
- p.Asp851Tyr Single submitter ⚠
- p.Cys308Phe Single submitter ⚠
- p.Cys884Arg Single submitter ⚠
- p.Gln150Lys Single submitter ⚠
- p.Gln554Lys Single submitter ⚠
- p.Gln708Arg Single submitter ⚠
- p.Gln808Leu Single submitter ⚠
- p.Gln845His Single submitter ⚠
- p.Gln869Arg Single submitter ⚠
- p.Glu130Lys Single submitter ⚠
- p.Glu446Gly Single submitter ⚠
- p.Glu805Lys Single submitter ⚠
- p.Gly113Asp Single submitter ⚠
- p.Gly180Glu Single submitter ⚠
- p.Gly454Arg Single submitter ⚠
- p.Gly480Ala Single submitter ⚠
- p.Gly540Ala Single submitter ⚠
- p.Gly562Asp Single submitter ⚠
- p.Gly562Ser Single submitter
- p.Gly765Arg Single submitter ⚠
- p.Gly783Arg Single submitter ⚠
- p.His242Gln Single submitter ⚠
- p.Ile385Val Single submitter ⚠
- p.Ile396Leu Single submitter ⚠
- p.Ile698Val Single submitter ⚠
- p.Ile901Phe Single submitter ⚠
- p.Leu144Phe Single submitter ⚠
- p.Leu323Pro Single submitter ⚠
- p.Leu334Val Single submitter ⚠
- p.Leu455Val Single submitter ⚠
- p.Leu553Phe Single submitter ⚠
- p.Leu909Arg Single submitter ⚠
- p.Lys596Arg Single submitter ⚠
- p.Lys596Gln Single submitter ⚠
- p.Lys5Asn Single submitter ⚠
- p.Lys760Arg Single submitter ⚠
- p.Lys760Asn Single submitter ⚠
- p.Lys760Gln Single submitter ⚠
- p.Met56Val Single submitter ⚠
- p.Phe166Leu Single submitter ⚠
- p.Pro112Leu Single submitter ⚠
- p.Pro117Ser Single submitter ⚠
- p.Pro117Thr Single submitter
- p.Pro260Gln Single submitter ⚠
- p.Pro526Leu Single submitter ⚠
- p.Pro534Ser Single submitter
- p.Pro607Ser Single submitter ⚠
- p.Pro690Leu Single submitter ⚠
- p.Pro690Thr Single submitter ⚠
- p.Pro714Ala Single submitter ⚠
- p.Pro867Leu Single submitter ⚠
- p.Ser391Leu Single submitter ⚠
- p.Ser405Pro Single submitter ⚠
- p.Ser602Asn Single submitter ⚠
- p.Ser625Gly Single submitter ⚠
- p.Ser821Thr Single submitter ⚠
- p.Ser912Pro Single submitter ⚠
- p.Thr207Ile Single submitter ⚠
- p.Thr207Ser Single submitter ⚠
- p.Thr232Met Single submitter ⚠
- p.Thr251Lys Single submitter ⚠
- p.Thr296Ile Single submitter ⚠
- p.Thr348Ile Single submitter ⚠
- p.Thr402Asn Single submitter ⚠
- p.Thr411Met Single submitter ⚠
- p.Thr516Ser Single submitter
- p.Thr880Met Single submitter ⚠
- p.Val307Ala Single submitter ⚠
- p.Val425Ile Single submitter ⚠
- p.Val506Glu Single submitter ⚠
- p.Val508Met Single submitter ⚠
- p.Val543Leu Single submitter ⚠
- p.Val579Ile Single submitter ⚠
- p.Val824Ile Single submitter ⚠
- p.Val862Ile Single submitter ⚠