CLCA2 — 157 ClinVar variants

All ClinVar germline CLCA2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 146 flagged for review →

3 Benign · 11 Likely benign · 143 Uncertain significance

Full CLCA2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 146

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 85

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 61

The independent predictors disagree with each other — read with care.

All CLCA2 variants

Benign 3

p.Gln842= Multiple submitters
p.Thr845= Multiple submitters
p.Tyr155= Multiple submitters

Likely benign 11

c.585-4T>G Single submitter
p.Ala352Val Single submitter
p.Arg560Gln Single submitter ⚠
p.Arg737Gln Single submitter
p.Asn12Asp Single submitter
p.Asp355Asn Single submitter ⚠
p.Asp355Tyr Single submitter ⚠
p.Ile697Val Single submitter
p.Met525Thr Single submitter
p.Phe174= Single submitter
p.Ser303= Single submitter

Uncertain significance 143

p.Ala109Val Single submitter ⚠
p.Ala238Val Single submitter ⚠
p.Ala262Thr Single submitter ⚠
p.Ala334Asp Single submitter ⚠
p.Ala334Gly Single submitter ⚠
p.Ala335Ser Single submitter ⚠
p.Ala335Thr Single submitter ⚠
p.Ala386Ser Single submitter ⚠
p.Ala449Thr Single submitter ⚠
p.Ala532Val Single submitter ⚠
p.Ala588Thr Single submitter ⚠
p.Ala680Val Single submitter ⚠
p.Ala717Val Single submitter ⚠
p.Arg158Gln Single submitter ⚠
p.Arg158Pro Single submitter ⚠
p.Arg160Gln Single submitter ⚠
p.Arg373Gln Single submitter ⚠
p.Arg458Gly Single submitter ⚠
p.Arg596Cys Single submitter ⚠
p.Arg596His Single submitter ⚠
p.Arg684Ser Single submitter ⚠
p.Arg684Thr Single submitter ⚠
p.Arg732Ser Single submitter ⚠
p.Arg743Gln Single submitter ⚠
p.Arg78Gly Single submitter ⚠
p.Arg78Thr Single submitter ⚠
p.Arg79Ser Single submitter ⚠
p.Arg826Gln Single submitter ⚠
p.Arg867Gln Single submitter ⚠
p.Arg871Thr Single submitter ⚠
p.Asn179Ser Single submitter ⚠
p.Asn189Lys Single submitter ⚠
p.Asn472Asp Single submitter ⚠
p.Asn599Ile Single submitter ⚠
p.Asn891Ser Single submitter ⚠
p.Asp317Ala Single submitter ⚠
p.Asp37Val Single submitter ⚠
p.Asp542Asn Single submitter ⚠
p.Cys206Tyr Single submitter ⚠
p.Cys211Arg Single submitter ⚠
p.Cys211Gly Single submitter ⚠
p.Cys270Arg Single submitter ⚠
p.Cys313Phe Single submitter ⚠
p.Cys429Ser Single submitter ⚠
p.Gln332Arg Single submitter ⚠
p.Gln332Leu Single submitter ⚠
p.Gln492Arg Single submitter ⚠
p.Gln875Arg Single submitter ⚠
p.Glu608Ala Single submitter ⚠
p.Glu645Asp Single submitter ⚠
p.Glu734Lys Single submitter ⚠
p.Glu780Val Single submitter ⚠
p.Gly136Val Single submitter ⚠
p.Gly156Glu Single submitter ⚠
p.Gly159Asp Single submitter ⚠
p.Gly209Ser Single submitter ⚠
p.Gly358Val Single submitter ⚠
p.Gly399Glu Single submitter ⚠
p.Gly427Val Single submitter ⚠
p.Gly521Asp Single submitter ⚠
p.Gly521Val Single submitter ⚠
p.Gly714Ala Single submitter ⚠
p.Gly731Ser Single submitter ⚠
p.Gly758Val Single submitter ⚠
p.Gly832Asp Single submitter ⚠
p.Gly854Arg Single submitter ⚠
p.His120Arg Single submitter ⚠
p.His120Tyr Single submitter ⚠
p.His140Leu Single submitter ⚠
p.His286Tyr Single submitter ⚠
p.His346Arg Single submitter ⚠
p.His346Leu Single submitter ⚠
p.His508Arg Single submitter ⚠
p.His690Arg Single submitter ⚠
p.His850Tyr Single submitter ⚠
p.His924Arg Single submitter ⚠
p.Ile279Phe Single submitter ⚠
p.Ile342Val Single submitter ⚠
p.Ile345Thr Single submitter ⚠
p.Ile538Phe Single submitter ⚠
p.Ile770Met Single submitter ⚠
p.Ile836Val Single submitter ⚠
p.Ile902Thr Single submitter ⚠
p.Leu169Phe Single submitter ⚠
p.Leu18Val Single submitter ⚠
p.Leu316Val Single submitter ⚠
p.Leu564Phe Single submitter ⚠
p.Leu616Phe Single submitter ⚠
p.Lys134Gln Single submitter ⚠
p.Lys357Asn Single submitter ⚠
p.Lys357Glu Single submitter ⚠
p.Lys688Thr Single submitter ⚠
p.Lys806Glu Single submitter ⚠
p.Met291Arg Single submitter ⚠
p.Met723Thr Single submitter ⚠
p.Pro212Arg Single submitter ⚠
p.Pro212Leu Single submitter ⚠
p.Pro27Ser Single submitter ⚠
p.Pro298Leu Single submitter ⚠
p.Pro298Ser Single submitter ⚠
p.Pro451Ala Single submitter ⚠
p.Pro621Thr Single submitter ⚠
p.Pro713Arg Single submitter ⚠
p.Pro759Leu Single submitter ⚠
p.Pro890Ser Single submitter ⚠
p.Ser198Pro Single submitter ⚠
p.Ser219Arg Single submitter ⚠
p.Ser232Asn Single submitter ⚠
p.Ser24Leu Single submitter ⚠
p.Ser303Leu Single submitter ⚠
p.Ser320Arg Single submitter ⚠
p.Ser448Phe Single submitter ⚠
p.Ser598Thr Single submitter ⚠
p.Ser600Pro Single submitter ⚠
p.Ser615Gly Single submitter ⚠
p.Ser751Pro Single submitter ⚠
p.Ser751Thr Single submitter ⚠
p.Ser873Phe Single submitter ⚠
p.Thr126Ala Single submitter ⚠
p.Thr257Ala Single submitter ⚠
p.Thr382Ile Single submitter ⚠
p.Thr524Ala Single submitter ⚠
p.Thr529Met Single submitter ⚠
p.Thr606Ser Single submitter ⚠
p.Thr653Arg Single submitter ⚠
p.Thr782Ile Single submitter ⚠
p.Thr786Ile Single submitter ⚠
p.Thr798Ile Single submitter ⚠
p.Thr838Met Single submitter ⚠
p.Trp166Ser Single submitter ⚠
p.Trp739Gly Single submitter ⚠
p.Tyr411Phe Single submitter ⚠
p.Tyr549His Single submitter ⚠
p.Tyr633His Single submitter ⚠
p.Tyr71His Single submitter ⚠
p.Val16Leu Single submitter ⚠
p.Val205Ala Single submitter ⚠
p.Val249Leu Single submitter ⚠
p.Val51Ile Single submitter ⚠
p.Val611Ala Single submitter ⚠
p.Val689Met Single submitter ⚠
p.Val691Ala Single submitter ⚠
p.Val712Ile Single submitter ⚠