Sugi Variant

Sugi Variant/CLCF1

CLCF1 — 65 ClinVar variants

All ClinVar germline CLCF1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →

4 Pathogenic · 1 Conflicting · 4 Benign · 1 Benign/Likely benign · 14 Likely benign · 41 Uncertain significance

Full CLCF1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 34

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 25

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 8

The independent predictors disagree with each other — read with care.

All CLCF1 variants

Pathogenic 4

  • p.Arg197Leu No assertion criteria cold-induced sweating syndrome 2
  • p.Cys16Arg No assertion criteria cold-induced sweating syndrome 2
  • p.Ter226Arg No assertion criteria cold-induced sweating syndrome 2
  • p.Tyr107Ter No assertion criteria cold-induced sweating syndrome 2

Conflicting classifications of pathogenicity 1

Benign 4

Benign/Likely benign 1

Likely benign 14

Uncertain significance 41