Sugi Variant

Sugi Variant/CLCNKB

CLCNKB — 564 ClinVar variants

All ClinVar germline CLCNKB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 185 flagged for review →

27 Pathogenic · 9 Pathogenic/Likely pathogenic · 24 Likely pathogenic · 17 Conflicting · 128 Benign · 8 Benign/Likely benign · 166 Likely benign · 185 Uncertain significance

Full CLCNKB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 185

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 9

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 89

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 86

The independent predictors disagree with each other — read with care.

All CLCNKB variants

Pathogenic 27

Pathogenic/Likely pathogenic 9

Likely pathogenic 24

Conflicting classifications of pathogenicity 17

Benign 128

Benign/Likely benign 8

Likely benign 166

Uncertain significance 185