CLDN12 — 18 ClinVar variants
All ClinVar germline CLDN12 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
18 Uncertain significance
Full CLDN12 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 10
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLDN12 p.Arg37Gln Uncertain significance Single submitter
- CLDN12 p.Gly17Arg Uncertain significance Single submitter
- CLDN12 p.Ile179Val Uncertain significance Single submitter
- CLDN12 p.Leu122Gln Uncertain significance Single submitter
- CLDN12 p.Met217Val Uncertain significance Single submitter
- CLDN12 p.Phe25Val Uncertain significance Single submitter
- CLDN12 p.Pro205Ser Uncertain significance Single submitter
- CLDN12 p.Pro91Ser Uncertain significance Single submitter
- CLDN12 p.Ser151Cys Uncertain significance Single submitter
- CLDN12 p.Thr243Ala Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- CLDN12 p.Ala8Thr Uncertain significance Single submitter
- CLDN12 p.Arg4Trp Uncertain significance Single submitter
- CLDN12 p.Gly63Arg Uncertain significance Single submitter
- CLDN12 p.Ile96Met Uncertain significance Single submitter
- CLDN12 p.Thr40Pro Uncertain significance Single submitter
- CLDN12 p.Trp207Cys Uncertain significance Single submitter
- CLDN12 p.Tyr173Cys Uncertain significance Single submitter
- CLDN12 p.Tyr61Cys Uncertain significance Single submitter
All CLDN12 variants
Uncertain significance 18
- p.Ala8Thr Single submitter ⚠
- p.Arg37Gln Single submitter ⚠
- p.Arg4Trp Single submitter ⚠
- p.Gly17Arg Single submitter ⚠
- p.Gly63Arg Single submitter ⚠
- p.Ile179Val Single submitter ⚠
- p.Ile96Met Single submitter ⚠
- p.Leu122Gln Single submitter ⚠
- p.Met217Val Single submitter ⚠
- p.Phe25Val Single submitter ⚠
- p.Pro205Ser Single submitter ⚠
- p.Pro91Ser Single submitter ⚠
- p.Ser151Cys Single submitter ⚠
- p.Thr243Ala Single submitter ⚠
- p.Thr40Pro Single submitter ⚠
- p.Trp207Cys Single submitter ⚠
- p.Tyr173Cys Single submitter ⚠
- p.Tyr61Cys Single submitter ⚠