CLDN15 — 31 ClinVar variants
All ClinVar germline CLDN15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
31 Uncertain significance
Full CLDN15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLDN15 p.Ala120Ser Uncertain significance Single submitter
- CLDN15 p.Ala209Thr Uncertain significance Single submitter
- CLDN15 p.Asp190Asn Uncertain significance Single submitter
- CLDN15 p.Gln213Glu Uncertain significance Single submitter
- CLDN15 p.Glu189Lys Uncertain significance Single submitter
- CLDN15 p.Glu214Gly Uncertain significance Single submitter
- CLDN15 p.Gly107Asp Uncertain significance Single submitter
- CLDN15 p.Leu177Phe Uncertain significance Single submitter
- CLDN15 p.Leu87Ile Uncertain significance Single submitter
- CLDN15 p.Leu91Phe Uncertain significance Single submitter
- CLDN15 p.Lys115Arg Uncertain significance Single submitter
- CLDN15 p.Phe50Val Uncertain significance Single submitter
- CLDN15 p.Pro191Thr Uncertain significance Single submitter
- CLDN15 p.Pro66Ser Uncertain significance Single submitter
- CLDN15 p.Ser167Gly Uncertain significance Single submitter
- CLDN15 p.Thr154Ile Uncertain significance Single submitter
- CLDN15 p.Val203Ala Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- CLDN15 p.Ala134Thr Uncertain significance Single submitter
- CLDN15 p.Ala85Thr Uncertain significance Single submitter
- CLDN15 p.Ile105Thr Uncertain significance Single submitter
- CLDN15 p.Ile129Thr Uncertain significance Single submitter
- CLDN15 p.Leu179Phe Uncertain significance Single submitter
- CLDN15 p.Met68Thr Uncertain significance Single submitter
- CLDN15 p.Phe10Tyr Uncertain significance Single submitter
- CLDN15 p.Ser2Leu Uncertain significance Single submitter
- CLDN15 p.Thr103Ile Uncertain significance Single submitter
- CLDN15 p.Thr154Ser Uncertain significance Single submitter
- CLDN15 p.Tyr60Cys Uncertain significance Single submitter
- CLDN15 p.Val208Ile Uncertain significance Single submitter
- CLDN15 p.Val31Met Uncertain significance Single submitter
- CLDN15 p.Val5Ala Uncertain significance Single submitter
All CLDN15 variants
Uncertain significance 31
- p.Ala120Ser Single submitter ⚠
- p.Ala134Thr Single submitter ⚠
- p.Ala209Thr Single submitter ⚠
- p.Ala85Thr Single submitter ⚠
- p.Asp190Asn Single submitter ⚠
- p.Gln213Glu Single submitter ⚠
- p.Glu189Lys Single submitter ⚠
- p.Glu214Gly Single submitter ⚠
- p.Gly107Asp Single submitter ⚠
- p.Ile105Thr Single submitter ⚠
- p.Ile129Thr Single submitter ⚠
- p.Leu177Phe Single submitter ⚠
- p.Leu179Phe Single submitter ⚠
- p.Leu87Ile Single submitter ⚠
- p.Leu91Phe Single submitter ⚠
- p.Lys115Arg Single submitter ⚠
- p.Met68Thr Single submitter ⚠
- p.Phe10Tyr Single submitter ⚠
- p.Phe50Val Single submitter ⚠
- p.Pro191Thr Single submitter ⚠
- p.Pro66Ser Single submitter ⚠
- p.Ser167Gly Single submitter ⚠
- p.Ser2Leu Single submitter ⚠
- p.Thr103Ile Single submitter ⚠
- p.Thr154Ile Single submitter ⚠
- p.Thr154Ser Single submitter ⚠
- p.Tyr60Cys Single submitter ⚠
- p.Val203Ala Single submitter ⚠
- p.Val208Ile Single submitter ⚠
- p.Val31Met Single submitter ⚠
- p.Val5Ala Single submitter ⚠