CLDN17 — 35 ClinVar variants
All ClinVar germline CLDN17 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
3 Likely benign · 32 Uncertain significance
Full CLDN17 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLDN17 p.Ala58Asp Uncertain significance Single submitter
- CLDN17 p.Ala80Pro Uncertain significance Single submitter
- CLDN17 p.Ala82Asp Uncertain significance Single submitter
- CLDN17 p.Gly156Ser Uncertain significance Single submitter
- CLDN17 p.Ile135Val Uncertain significance Single submitter
- CLDN17 p.Ile145Thr Uncertain significance Single submitter
- CLDN17 p.Ile155Met Uncertain significance Single submitter
- CLDN17 p.Ile41Asn Uncertain significance Single submitter
- CLDN17 p.Leu181Arg Uncertain significance Single submitter
- CLDN17 p.Leu62Phe Uncertain significance Single submitter
- CLDN17 p.Leu71Ser Uncertain significance Single submitter
- CLDN17 p.Met18Arg Uncertain significance Single submitter
- CLDN17 p.Pro5His Uncertain significance Single submitter
- CLDN17 p.Ser68Asn Uncertain significance Single submitter
- CLDN17 p.Thr24Lys Uncertain significance Single submitter
- CLDN17 p.Val12Leu Uncertain significance Single submitter
- CLDN17 p.Val174Leu Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- CLDN17 p.Ala141Gly Uncertain significance Single submitter
- CLDN17 p.Arg203Cys Likely benign Single submitter
- CLDN17 p.Arg61Trp Uncertain significance Single submitter
- CLDN17 p.Cys187Arg Uncertain significance Single submitter
- CLDN17 p.Leu161Pro Uncertain significance Single submitter
- CLDN17 p.Leu73Arg Uncertain significance Single submitter
- CLDN17 p.Leu73Phe Uncertain significance Single submitter
- CLDN17 p.Lys115Glu Uncertain significance Single submitter
- CLDN17 p.Met84Val Uncertain significance Single submitter
- CLDN17 p.Pro74Leu Uncertain significance Single submitter
- CLDN17 p.Thr129Met Uncertain significance Single submitter
- CLDN17 p.Thr213Lys Uncertain significance Single submitter
- CLDN17 p.Tyr149Cys Uncertain significance Single submitter
- CLDN17 p.Val32Glu Uncertain significance Single submitter
- CLDN17 p.Val42Ala Uncertain significance Single submitter
- CLDN17 p.Val88Ala Uncertain significance Single submitter
All CLDN17 variants
Likely benign 3
- p.Ala114Val Single submitter
- p.Arg203Cys Single submitter ⚠
- p.Thr79Ala Single submitter
Uncertain significance 32
- p.Ala141Gly Single submitter ⚠
- p.Ala58Asp Single submitter ⚠
- p.Ala80Pro Single submitter ⚠
- p.Ala82Asp Single submitter ⚠
- p.Arg61Trp Single submitter ⚠
- p.Cys187Arg Single submitter ⚠
- p.Gly156Ser Single submitter ⚠
- p.Ile135Val Single submitter ⚠
- p.Ile145Thr Single submitter ⚠
- p.Ile155Met Single submitter ⚠
- p.Ile41Asn Single submitter ⚠
- p.Leu161Pro Single submitter ⚠
- p.Leu181Arg Single submitter ⚠
- p.Leu62Phe Single submitter ⚠
- p.Leu71Ser Single submitter ⚠
- p.Leu73Arg Single submitter ⚠
- p.Leu73Phe Single submitter ⚠
- p.Lys115Glu Single submitter ⚠
- p.Met18Arg Single submitter ⚠
- p.Met84Val Single submitter ⚠
- p.Pro5His Single submitter ⚠
- p.Pro74Leu Single submitter ⚠
- p.Ser68Asn Single submitter ⚠
- p.Thr129Met Single submitter ⚠
- p.Thr213Lys Single submitter ⚠
- p.Thr24Lys Single submitter ⚠
- p.Tyr149Cys Single submitter ⚠
- p.Val12Leu Single submitter ⚠
- p.Val174Leu Single submitter ⚠
- p.Val32Glu Single submitter ⚠
- p.Val42Ala Single submitter ⚠
- p.Val88Ala Single submitter ⚠