CLDN18 — 38 ClinVar variants
All ClinVar germline CLDN18 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
2 Likely benign · 36 Uncertain significance
Full CLDN18 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLDN18 p.Gly230Ser Uncertain significance Multiple submitters
- CLDN18 p.Ala181Thr Uncertain significance Single submitter
- CLDN18 p.Ala195Val Uncertain significance Single submitter
- CLDN18 p.Ala78Val Uncertain significance Single submitter
- CLDN18 p.Ala81Val Uncertain significance Single submitter
- CLDN18 p.Asn146His Uncertain significance Single submitter
- CLDN18 p.Cys193Ser Uncertain significance Single submitter
- CLDN18 p.Gln56His Uncertain significance Single submitter
- CLDN18 p.Gly157Ser Uncertain significance Single submitter
- CLDN18 p.Gly243Glu Uncertain significance Single submitter
- CLDN18 p.Ile92Val Uncertain significance Single submitter
- CLDN18 p.Lys257Arg Uncertain significance Single submitter
- CLDN18 p.Met154Ile Uncertain significance Single submitter
- CLDN18 p.Met192Lys Uncertain significance Single submitter
- CLDN18 p.Ser121Phe Uncertain significance Single submitter
- CLDN18 p.Thr5Ser Uncertain significance Single submitter
- CLDN18 p.Trp179Ser Uncertain significance Single submitter
- CLDN18 p.Val177Met Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- CLDN18 p.Ala140Gly Uncertain significance Single submitter
- CLDN18 p.Ala173Thr Uncertain significance Single submitter
- CLDN18 p.Arg105Cys Uncertain significance Single submitter
- CLDN18 p.Arg197Gln Uncertain significance Single submitter
- CLDN18 p.Cys193Gly Uncertain significance Single submitter
- CLDN18 p.Glu250Lys Uncertain significance Single submitter
- CLDN18 p.Gly159Asp Uncertain significance Single submitter
- CLDN18 p.His212Asp Uncertain significance Single submitter
- CLDN18 p.Ile126Thr Uncertain significance Single submitter
- CLDN18 p.Ile92Thr Uncertain significance Single submitter
- CLDN18 p.Ile98Thr Uncertain significance Single submitter
- CLDN18 p.Leu175Val Uncertain significance Single submitter
- CLDN18 p.Leu94Phe Uncertain significance Single submitter
- CLDN18 p.Met142Ile Uncertain significance Single submitter
- CLDN18 p.Phe44Leu Uncertain significance Single submitter
- CLDN18 p.Pro39Leu Uncertain significance Single submitter
- CLDN18 p.Tyr254His Likely benign Single submitter
- CLDN18 p.Val85Ala Uncertain significance Single submitter
All CLDN18 variants
Likely benign 2
- p.Ala173Ser Single submitter
- p.Tyr254His Single submitter ⚠
Uncertain significance 36
- p.Gly230Ser Multiple submitters ⚠
- p.Ala140Gly Single submitter ⚠
- p.Ala173Thr Single submitter ⚠
- p.Ala181Thr Single submitter ⚠
- p.Ala195Val Single submitter ⚠
- p.Ala78Val Single submitter ⚠
- p.Ala81Val Single submitter ⚠
- p.Arg105Cys Single submitter ⚠
- p.Arg197Gln Single submitter ⚠
- p.Asn146His Single submitter ⚠
- p.Cys193Gly Single submitter ⚠
- p.Cys193Ser Single submitter ⚠
- p.Gln56His Single submitter ⚠
- p.Glu250Lys Single submitter ⚠
- p.Gly157Ser Single submitter ⚠
- p.Gly159Asp Single submitter ⚠
- p.Gly243Glu Single submitter ⚠
- p.His212Asp Single submitter ⚠
- p.Ile126Thr Single submitter ⚠
- p.Ile92Thr Single submitter ⚠
- p.Ile92Val Single submitter ⚠
- p.Ile98Thr Single submitter ⚠
- p.Leu175Val Single submitter ⚠
- p.Leu94Phe Single submitter ⚠
- p.Lys257Arg Single submitter ⚠
- p.Met142Ile Single submitter ⚠
- p.Met154Ile Single submitter ⚠
- p.Met192Lys Single submitter ⚠
- p.Phe44Leu Single submitter ⚠
- p.Pro39Leu Single submitter ⚠
- p.Ser121Phe Single submitter ⚠
- p.Thr5Ser Single submitter ⚠
- p.Trp179Ser Single submitter ⚠
- p.Tyr36Ser Single submitter
- p.Val177Met Single submitter ⚠
- p.Val85Ala Single submitter ⚠