CLDN20 — 29 ClinVar variants
All ClinVar germline CLDN20 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
1 Benign · 28 Uncertain significance
Full CLDN20 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLDN20 p.Ala117Val Uncertain significance Single submitter
- CLDN20 p.Arg106Cys Uncertain significance Single submitter
- CLDN20 p.Asn156Ser Uncertain significance Single submitter
- CLDN20 p.Asn29Ser Uncertain significance Single submitter
- CLDN20 p.Asn33Ser Uncertain significance Single submitter
- CLDN20 p.Cys96Arg Uncertain significance Single submitter
- CLDN20 p.Gln46Arg Uncertain significance Single submitter
- CLDN20 p.Gly161Arg Uncertain significance Single submitter
- CLDN20 p.Gly49Arg Uncertain significance Single submitter
- CLDN20 p.Ile144Thr Uncertain significance Single submitter
- CLDN20 p.Ile202Thr Uncertain significance Single submitter
- CLDN20 p.Ile41Val Uncertain significance Single submitter
- CLDN20 p.Leu215Pro Uncertain significance Single submitter
- CLDN20 p.Leu27Arg Uncertain significance Single submitter
- CLDN20 p.Pro190Ser Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- CLDN20 p.Ala120Pro Uncertain significance Single submitter
- CLDN20 p.Ala80Val Uncertain significance Single submitter
- CLDN20 p.Asn39Asp Uncertain significance Single submitter
- CLDN20 p.Asp149His Uncertain significance Single submitter
- CLDN20 p.Cys185Tyr Uncertain significance Single submitter
- CLDN20 p.Gln78Lys Uncertain significance Single submitter
- CLDN20 p.Ile164Thr Uncertain significance Single submitter
- CLDN20 p.Leu6Phe Uncertain significance Single submitter
- CLDN20 p.Ser135Leu Uncertain significance Single submitter
- CLDN20 p.Ser211Tyr Uncertain significance Single submitter
- CLDN20 p.Thr55Arg Uncertain significance Single submitter
- CLDN20 p.Thr55Met Uncertain significance Single submitter
- CLDN20 p.Val152Ala Uncertain significance Single submitter
All CLDN20 variants
Benign 1
- p.Gly94Glu Single submitter
Uncertain significance 28
- p.Ala117Val Single submitter ⚠
- p.Ala120Pro Single submitter ⚠
- p.Ala80Val Single submitter ⚠
- p.Arg106Cys Single submitter ⚠
- p.Asn156Ser Single submitter ⚠
- p.Asn29Ser Single submitter ⚠
- p.Asn33Ser Single submitter ⚠
- p.Asn39Asp Single submitter ⚠
- p.Asp149His Single submitter ⚠
- p.Cys185Tyr Single submitter ⚠
- p.Cys96Arg Single submitter ⚠
- p.Gln46Arg Single submitter ⚠
- p.Gln78Lys Single submitter ⚠
- p.Gly161Arg Single submitter ⚠
- p.Gly49Arg Single submitter ⚠
- p.Ile144Thr Single submitter ⚠
- p.Ile164Thr Single submitter ⚠
- p.Ile202Thr Single submitter ⚠
- p.Ile41Val Single submitter ⚠
- p.Leu215Pro Single submitter ⚠
- p.Leu27Arg Single submitter ⚠
- p.Leu6Phe Single submitter ⚠
- p.Pro190Ser Single submitter ⚠
- p.Ser135Leu Single submitter ⚠
- p.Ser211Tyr Single submitter ⚠
- p.Thr55Arg Single submitter ⚠
- p.Thr55Met Single submitter ⚠
- p.Val152Ala Single submitter ⚠