CLDN22 — 35 ClinVar variants
All ClinVar germline CLDN22 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
4 Likely benign · 31 Uncertain significance
Full CLDN22 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLDN22 p.Ala192Thr Uncertain significance Single submitter
- CLDN22 p.Asn88Asp Uncertain significance Single submitter
- CLDN22 p.Cys181Phe Uncertain significance Single submitter
- CLDN22 p.Cys64Gly Uncertain significance Single submitter
- CLDN22 p.Gln111His Uncertain significance Single submitter
- CLDN22 p.Gly13Arg Uncertain significance Single submitter
- CLDN22 p.Gly179Glu Uncertain significance Single submitter
- CLDN22 p.Gly197Asp Uncertain significance Single submitter
- CLDN22 p.Lys219Ile Uncertain significance Single submitter
- CLDN22 p.Met84Ile Uncertain significance Single submitter
- CLDN22 p.Phe162Ser Uncertain significance Single submitter
- CLDN22 p.Phe67Ser Uncertain significance Single submitter
- CLDN22 p.Ser190Gly Uncertain significance Single submitter
- CLDN22 p.Ser24Pro Uncertain significance Single submitter
- CLDN22 p.Thr216Ile Uncertain significance Single submitter
- CLDN22 p.Thr47Asn Uncertain significance Single submitter
- CLDN22 p.Trp46Arg Uncertain significance Single submitter
- CLDN22 p.Val140Ala Uncertain significance Single submitter
- CLDN22 p.Val201Ala Uncertain significance Single submitter
- CLDN22 p.Val79Ala Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- CLDN22 p.Asp103Asn Uncertain significance Single submitter
- CLDN22 p.Cys185Arg Uncertain significance Single submitter
- CLDN22 p.Cys188Tyr Uncertain significance Single submitter
- CLDN22 p.Glu42Lys Uncertain significance Single submitter
- CLDN22 p.Glu76Lys Uncertain significance Single submitter
- CLDN22 p.Ile107Thr Likely benign Single submitter
- CLDN22 p.Leu90Met Uncertain significance Single submitter
- CLDN22 p.Leu93Pro Uncertain significance Single submitter
- CLDN22 p.Phe171Tyr Uncertain significance Single submitter
- CLDN22 p.Ser17Pro Uncertain significance Single submitter
- CLDN22 p.Thr144Met Uncertain significance Single submitter
- CLDN22 p.Val137Ile Uncertain significance Single submitter
All CLDN22 variants
Likely benign 4
- p.His184Asn Single submitter
- p.Ile107Thr Single submitter ⚠
- p.Ile124Val Single submitter
- p.Ser110Arg Single submitter
Uncertain significance 31
- p.Ala192Thr Single submitter ⚠
- p.Asn88Asp Single submitter ⚠
- p.Asp103Asn Single submitter ⚠
- p.Cys181Phe Single submitter ⚠
- p.Cys185Arg Single submitter ⚠
- p.Cys188Tyr Single submitter ⚠
- p.Cys64Gly Single submitter ⚠
- p.Gln111His Single submitter ⚠
- p.Glu42Lys Single submitter ⚠
- p.Glu76Lys Single submitter ⚠
- p.Gly13Arg Single submitter ⚠
- p.Gly179Glu Single submitter ⚠
- p.Gly197Asp Single submitter ⚠
- p.Leu90Met Single submitter ⚠
- p.Leu93Pro Single submitter ⚠
- p.Lys219Ile Single submitter ⚠
- p.Met84Ile Single submitter ⚠
- p.Phe162Ser Single submitter ⚠
- p.Phe171Tyr Single submitter ⚠
- p.Phe67Ser Single submitter ⚠
- p.Ser17Pro Single submitter ⚠
- p.Ser190Gly Single submitter ⚠
- p.Ser24Pro Single submitter ⚠
- p.Thr144Met Single submitter ⚠
- p.Thr216Ile Single submitter ⚠
- p.Thr47Asn Single submitter ⚠
- p.Trp46Arg Single submitter ⚠
- p.Val137Ile Single submitter ⚠
- p.Val140Ala Single submitter ⚠
- p.Val201Ala Single submitter ⚠
- p.Val79Ala Single submitter ⚠