CLDN23 — 69 ClinVar variants
All ClinVar germline CLDN23 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
3 Likely benign · 66 Uncertain significance
Full CLDN23 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLDN23 p.Ala149Pro Uncertain significance Single submitter
- CLDN23 p.Ala14Val Uncertain significance Single submitter
- CLDN23 p.Ala198Thr Uncertain significance Single submitter
- CLDN23 p.Arg188Cys Uncertain significance Single submitter
- CLDN23 p.Arg202His Uncertain significance Single submitter
- CLDN23 p.Arg237Ser Uncertain significance Single submitter
- CLDN23 p.Arg59Cys Uncertain significance Single submitter
- CLDN23 p.Arg59His Uncertain significance Single submitter
- CLDN23 p.Asn110Ser Uncertain significance Single submitter
- CLDN23 p.Asp226Asn Uncertain significance Single submitter
- CLDN23 p.Asp265Tyr Uncertain significance Single submitter
- CLDN23 p.Gln39Pro Uncertain significance Single submitter
- CLDN23 p.Gln68His Uncertain significance Single submitter
- CLDN23 p.Glu214Lys Uncertain significance Single submitter
- CLDN23 p.Gly101Cys Uncertain significance Single submitter
- CLDN23 p.Gly195Arg Uncertain significance Single submitter
- CLDN23 p.Gly227Ser Uncertain significance Single submitter
- CLDN23 p.Gly266Arg Uncertain significance Single submitter
- CLDN23 p.Gly35Asp Uncertain significance Single submitter
- CLDN23 p.His236Leu Uncertain significance Single submitter
- CLDN23 p.Leu9Gln Uncertain significance Single submitter
- CLDN23 p.Met11Thr Uncertain significance Single submitter
- CLDN23 p.Met249Ile Uncertain significance Single submitter
- CLDN23 p.Pro131Leu Uncertain significance Single submitter
- CLDN23 p.Pro183Arg Uncertain significance Single submitter
- CLDN23 p.Pro231Leu Uncertain significance Single submitter
- CLDN23 p.Pro248Arg Uncertain significance Single submitter
- CLDN23 p.Pro4Ser Uncertain significance Single submitter
- CLDN23 p.Ser157Ile Uncertain significance Single submitter
- CLDN23 p.Ser157Thr Uncertain significance Single submitter
- CLDN23 p.Ser57Asn Uncertain significance Single submitter
- CLDN23 p.Thr91Lys Uncertain significance Single submitter
- CLDN23 p.Trp134Ser Uncertain significance Single submitter
- CLDN23 p.Val123Ile Uncertain significance Single submitter
- CLDN23 p.Val245Ile Uncertain significance Single submitter
- CLDN23 p.Val263Ile Uncertain significance Single submitter
- CLDN23 p.Val33Gly Uncertain significance Single submitter
- CLDN23 p.Val43Leu Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- CLDN23 p.Ala27Gly Uncertain significance Single submitter
- CLDN23 p.Ala74Asp Uncertain significance Single submitter
- CLDN23 p.Ala82Thr Uncertain significance Single submitter
- CLDN23 p.Arg193Cys Uncertain significance Single submitter
- CLDN23 p.Arg193Leu Uncertain significance Single submitter
- CLDN23 p.Arg201Cys Uncertain significance Single submitter
- CLDN23 p.Arg253Trp Uncertain significance Single submitter
- CLDN23 p.Arg61His Uncertain significance Single submitter
- CLDN23 p.Asn21Lys Uncertain significance Single submitter
- CLDN23 p.Asp141His Uncertain significance Single submitter
- CLDN23 p.Asp273Asn Uncertain significance Single submitter
- CLDN23 p.Asp283Asn Uncertain significance Single submitter
- CLDN23 p.Asp289Ala Uncertain significance Single submitter
- CLDN23 p.Gly166Ala Uncertain significance Single submitter
- CLDN23 p.Gly166Ser Uncertain significance Single submitter
- CLDN23 p.Leu162Val Uncertain significance Single submitter
- CLDN23 p.Leu171Met Uncertain significance Single submitter
- CLDN23 p.Phe138Leu Uncertain significance Single submitter
- CLDN23 p.Pro151Leu Uncertain significance Single submitter
- CLDN23 p.Pro15Ser Uncertain significance Single submitter
- CLDN23 p.Pro239Ser Uncertain significance Single submitter
- CLDN23 p.Pro241Arg Uncertain significance Single submitter
- CLDN23 p.Ser157Asn Uncertain significance Single submitter
- CLDN23 p.Ser204Thr Uncertain significance Single submitter
- CLDN23 p.Thr153Met Uncertain significance Single submitter
- CLDN23 p.Trp184Ser Uncertain significance Single submitter
- CLDN23 p.Val112Met Uncertain significance Single submitter
- CLDN23 p.Val154Leu Uncertain significance Single submitter
All CLDN23 variants
Likely benign 3
- p.Ala274Ser Single submitter
- p.Ala90Thr Single submitter
- p.Gly128Ser Single submitter
Uncertain significance 66
- p.Ala149Pro Single submitter ⚠
- p.Ala14Val Single submitter ⚠
- p.Ala198Thr Single submitter ⚠
- p.Ala27Gly Single submitter ⚠
- p.Ala74Asp Single submitter ⚠
- p.Ala82Thr Single submitter ⚠
- p.Arg188Cys Single submitter ⚠
- p.Arg193Cys Single submitter ⚠
- p.Arg193Leu Single submitter ⚠
- p.Arg201Cys Single submitter ⚠
- p.Arg202His Single submitter ⚠
- p.Arg237Ser Single submitter ⚠
- p.Arg253Trp Single submitter ⚠
- p.Arg59Cys Single submitter ⚠
- p.Arg59His Single submitter ⚠
- p.Arg61His Single submitter ⚠
- p.Asn110Ser Single submitter ⚠
- p.Asn21Lys Single submitter ⚠
- p.Asp141His Single submitter ⚠
- p.Asp226Asn Single submitter ⚠
- p.Asp265Tyr Single submitter ⚠
- p.Asp273Asn Single submitter ⚠
- p.Asp283Asn Single submitter ⚠
- p.Asp289Ala Single submitter ⚠
- p.Gln39Pro Single submitter ⚠
- p.Gln68His Single submitter ⚠
- p.Glu214Lys Single submitter ⚠
- p.Gly101Cys Single submitter ⚠
- p.Gly166Ala Single submitter ⚠
- p.Gly166Ser Single submitter ⚠
- p.Gly195Arg Single submitter ⚠
- p.Gly227Ser Single submitter ⚠
- p.Gly266Arg Single submitter ⚠
- p.Gly35Asp Single submitter ⚠
- p.His236Leu Single submitter ⚠
- p.Leu162Val Single submitter ⚠
- p.Leu171Met Single submitter ⚠
- p.Leu9Gln Single submitter ⚠
- p.Met11Thr Single submitter ⚠
- p.Met249Ile Single submitter ⚠
- p.Phe138Leu Single submitter ⚠
- p.Pro131Leu Single submitter ⚠
- p.Pro151Leu Single submitter ⚠
- p.Pro15Ser Single submitter ⚠
- p.Pro183Arg Single submitter ⚠
- p.Pro231Leu Single submitter ⚠
- p.Pro239Ser Single submitter ⚠
- p.Pro241Arg Single submitter ⚠
- p.Pro248Arg Single submitter ⚠
- p.Pro4Ser Single submitter ⚠
- p.Ser157Asn Single submitter ⚠
- p.Ser157Ile Single submitter ⚠
- p.Ser157Thr Single submitter ⚠
- p.Ser204Thr Single submitter ⚠
- p.Ser57Asn Single submitter ⚠
- p.Thr153Met Single submitter ⚠
- p.Thr91Lys Single submitter ⚠
- p.Trp134Ser Single submitter ⚠
- p.Trp184Ser Single submitter ⚠
- p.Val112Met Single submitter ⚠
- p.Val123Ile Single submitter ⚠
- p.Val154Leu Single submitter ⚠
- p.Val245Ile Single submitter ⚠
- p.Val263Ile Single submitter ⚠
- p.Val33Gly Single submitter ⚠
- p.Val43Leu Single submitter ⚠