CLDN24 — 29 ClinVar variants
All ClinVar germline CLDN24 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
3 Likely benign · 26 Uncertain significance
Full CLDN24 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLDN24 p.Ala202Val Uncertain significance Single submitter
- CLDN24 p.Ala216Thr Uncertain significance Single submitter
- CLDN24 p.Arg6Thr Uncertain significance Single submitter
- CLDN24 p.Cys185Trp Uncertain significance Single submitter
- CLDN24 p.Cys54Arg Uncertain significance Single submitter
- CLDN24 p.Glu212Gln Uncertain significance Single submitter
- CLDN24 p.Glu44Asp Uncertain significance Single submitter
- CLDN24 p.Glu59Ala Uncertain significance Single submitter
- CLDN24 p.Gly20Arg Uncertain significance Single submitter
- CLDN24 p.Gly99Arg Uncertain significance Single submitter
- CLDN24 p.Ile107Phe Uncertain significance Single submitter
- CLDN24 p.Ile4Leu Uncertain significance Single submitter
- CLDN24 p.Leu177Pro Uncertain significance Single submitter
- CLDN24 p.Lys115Thr Uncertain significance Single submitter
- CLDN24 p.Lys143Arg Uncertain significance Single submitter
- CLDN24 p.Trp127Arg Uncertain significance Single submitter
- CLDN24 p.Trp51Cys Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- CLDN24 p.Arg6Lys Uncertain significance Single submitter
- CLDN24 p.Gln63Arg Uncertain significance Single submitter
- CLDN24 p.Ile107Thr Likely benign Single submitter
- CLDN24 p.Ile120Asn Uncertain significance Single submitter
- CLDN24 p.Leu40Phe Uncertain significance Single submitter
- CLDN24 p.Met62Ile Uncertain significance Single submitter
- CLDN24 p.Ser69Thr Uncertain significance Single submitter
- CLDN24 p.Thr144Met Uncertain significance Single submitter
- CLDN24 p.Val135Leu Uncertain significance Single submitter
- CLDN24 p.Val137Ile Uncertain significance Single submitter
All CLDN24 variants
Likely benign 3
- p.Asn184His Single submitter
- p.Ile107Thr Single submitter ⚠
- p.Val153Ile Single submitter
Uncertain significance 26
- p.Ala202Val Single submitter ⚠
- p.Ala216Thr Single submitter ⚠
- p.Arg6Lys Single submitter ⚠
- p.Arg6Thr Single submitter ⚠
- p.Cys185Trp Single submitter ⚠
- p.Cys54Arg Single submitter ⚠
- p.Gln63Arg Single submitter ⚠
- p.Glu212Gln Single submitter ⚠
- p.Glu44Asp Single submitter ⚠
- p.Glu59Ala Single submitter ⚠
- p.Gly20Arg Single submitter ⚠
- p.Gly99Arg Single submitter ⚠
- p.Ile107Phe Single submitter ⚠
- p.Ile120Asn Single submitter ⚠
- p.Ile4Leu Single submitter ⚠
- p.Leu177Pro Single submitter ⚠
- p.Leu40Phe Single submitter ⚠
- p.Lys115Thr Single submitter ⚠
- p.Lys143Arg Single submitter ⚠
- p.Met62Ile Single submitter ⚠
- p.Ser69Thr Single submitter ⚠
- p.Thr144Met Single submitter ⚠
- p.Trp127Arg Single submitter ⚠
- p.Trp51Cys Single submitter ⚠
- p.Val135Leu Single submitter ⚠
- p.Val137Ile Single submitter ⚠