CLDN25 — 45 ClinVar variants
All ClinVar germline CLDN25 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
2 Likely benign · 43 Uncertain significance
Full CLDN25 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLDN25 p.Ala143Ser Uncertain significance Single submitter
- CLDN25 p.Ala61Asp Uncertain significance Single submitter
- CLDN25 p.Asp151Glu Uncertain significance Single submitter
- CLDN25 p.Cys208Arg Uncertain significance Single submitter
- CLDN25 p.Gln75Arg Uncertain significance Single submitter
- CLDN25 p.Gly119Arg Uncertain significance Single submitter
- CLDN25 p.His219Tyr Uncertain significance Single submitter
- CLDN25 p.Ile156Val Uncertain significance Single submitter
- CLDN25 p.Ile229Thr Uncertain significance Single submitter
- CLDN25 p.Leu18Phe Uncertain significance Single submitter
- CLDN25 p.Leu97Phe Uncertain significance Single submitter
- CLDN25 p.Met43Lys Uncertain significance Single submitter
- CLDN25 p.Met43Thr Uncertain significance Single submitter
- CLDN25 p.Phe148Leu Uncertain significance Single submitter
- CLDN25 p.Phe5Ser Uncertain significance Single submitter
- CLDN25 p.Pro205Arg Uncertain significance Single submitter
- CLDN25 p.Pro224Leu Uncertain significance Single submitter
- CLDN25 p.Thr124Ile Uncertain significance Single submitter
- CLDN25 p.Val60Ile Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- CLDN25 p.Ala171Thr Uncertain significance Single submitter
- CLDN25 p.Arg117Gln Uncertain significance Single submitter
- CLDN25 p.Arg117Trp Uncertain significance Single submitter
- CLDN25 p.Asn41Lys Uncertain significance Single submitter
- CLDN25 p.Asp147Asn Uncertain significance Single submitter
- CLDN25 p.Asp147His Uncertain significance Single submitter
- CLDN25 p.Cys64Phe Uncertain significance Single submitter
- CLDN25 p.Glu161Ala Uncertain significance Single submitter
- CLDN25 p.Glu42Lys Uncertain significance Single submitter
- CLDN25 p.Gly122Arg Uncertain significance Single submitter
- CLDN25 p.Gly13Arg Uncertain significance Single submitter
- CLDN25 p.Leu121Pro Uncertain significance Single submitter
- CLDN25 p.Leu36Phe Uncertain significance Single submitter
- CLDN25 p.Leu71Val Uncertain significance Single submitter
- CLDN25 p.Leu83Phe Uncertain significance Single submitter
- CLDN25 p.Lys8Asn Uncertain significance Single submitter
- CLDN25 p.Met48Val Uncertain significance Single submitter
- CLDN25 p.Pro158Ser Uncertain significance Single submitter
- CLDN25 p.Pro31Leu Uncertain significance Single submitter
- CLDN25 p.Trp139Ser Uncertain significance Single submitter
- CLDN25 p.Trp51Gly Uncertain significance Single submitter
- CLDN25 p.Val53Asp Uncertain significance Single submitter
- CLDN25 p.Val55Ala Uncertain significance Single submitter
- CLDN25 p.Val79Ile Uncertain significance Single submitter
All CLDN25 variants
Likely benign 2
- p.Asp56= Single submitter
- p.Leu222Pro Single submitter
Uncertain significance 43
- p.Ala143Ser Single submitter ⚠
- p.Ala171Thr Single submitter ⚠
- p.Ala61Asp Single submitter ⚠
- p.Arg117Gln Single submitter ⚠
- p.Arg117Trp Single submitter ⚠
- p.Asn41Lys Single submitter ⚠
- p.Asp147Asn Single submitter ⚠
- p.Asp147His Single submitter ⚠
- p.Asp151Glu Single submitter ⚠
- p.Cys208Arg Single submitter ⚠
- p.Cys64Phe Single submitter ⚠
- p.Gln75Arg Single submitter ⚠
- p.Glu161Ala Single submitter ⚠
- p.Glu42Lys Single submitter ⚠
- p.Gly119Arg Single submitter ⚠
- p.Gly122Arg Single submitter ⚠
- p.Gly13Arg Single submitter ⚠
- p.His219Tyr Single submitter ⚠
- p.Ile156Val Single submitter ⚠
- p.Ile229Thr Single submitter ⚠
- p.Leu121Pro Single submitter ⚠
- p.Leu18Phe Single submitter ⚠
- p.Leu36Phe Single submitter ⚠
- p.Leu71Val Single submitter ⚠
- p.Leu83Phe Single submitter ⚠
- p.Leu97Phe Single submitter ⚠
- p.Lys8Asn Single submitter ⚠
- p.Met43Lys Single submitter ⚠
- p.Met43Thr Single submitter ⚠
- p.Met48Val Single submitter ⚠
- p.Phe148Leu Single submitter ⚠
- p.Phe5Ser Single submitter ⚠
- p.Pro158Ser Single submitter ⚠
- p.Pro205Arg Single submitter ⚠
- p.Pro224Leu Single submitter ⚠
- p.Pro31Leu Single submitter ⚠
- p.Thr124Ile Single submitter ⚠
- p.Trp139Ser Single submitter ⚠
- p.Trp51Gly Single submitter ⚠
- p.Val53Asp Single submitter ⚠
- p.Val55Ala Single submitter ⚠
- p.Val60Ile Single submitter ⚠
- p.Val79Ile Single submitter ⚠