CLDN3 — 34 ClinVar variants
All ClinVar germline CLDN3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
34 Uncertain significance
Full CLDN3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLDN3 p.Ala127Ser Uncertain significance Single submitter
- CLDN3 p.Ala127Thr Uncertain significance Single submitter
- CLDN3 p.Ala128Ser Uncertain significance Single submitter
- CLDN3 p.Ala13Pro Uncertain significance Single submitter
- CLDN3 p.Ala170Pro Uncertain significance Single submitter
- CLDN3 p.Asp75His Uncertain significance Single submitter
- CLDN3 p.Cys24Tyr Uncertain significance Single submitter
- CLDN3 p.Ile143Asn Uncertain significance Single submitter
- CLDN3 p.Leu125Val Uncertain significance Single submitter
- CLDN3 p.Met28Ile Uncertain significance Single submitter
- CLDN3 p.Ser2Thr Uncertain significance Single submitter
- CLDN3 p.Ser42Trp Uncertain significance Single submitter
- CLDN3 p.Thr204Ser Uncertain significance Single submitter
- CLDN3 p.Thr212Ser Uncertain significance Single submitter
- CLDN3 p.Val22Leu Uncertain significance Single submitter
- CLDN3 p.Val31Leu Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- CLDN3 p.Ala112Thr Uncertain significance Single submitter
- CLDN3 p.Ala139Thr Uncertain significance Single submitter
- CLDN3 p.Ala13Val Uncertain significance Single submitter
- CLDN3 p.Ala178Val Uncertain significance Single submitter
- CLDN3 p.Ala81Ser Uncertain significance Single submitter
- CLDN3 p.Ala97Ser Uncertain significance Single submitter
- CLDN3 p.Arg187His Uncertain significance Single submitter
- CLDN3 p.Arg216Leu Uncertain significance Single submitter
- CLDN3 p.Glu153Lys Uncertain significance Single submitter
- CLDN3 p.Glu188Gly Uncertain significance Single submitter
- CLDN3 p.Gly36Ser Uncertain significance Single submitter
- CLDN3 p.Leu130Phe Uncertain significance Single submitter
- CLDN3 p.Lys189Asn Uncertain significance Single submitter
- CLDN3 p.Pro186Ser Uncertain significance Single submitter
- CLDN3 p.Thr192Lys Uncertain significance Single submitter
- CLDN3 p.Val165Leu Uncertain significance Single submitter
- CLDN3 p.Val22Met Uncertain significance Single submitter
- CLDN3 p.Val84Leu Uncertain significance Single submitter
All CLDN3 variants
Uncertain significance 34
- p.Ala112Thr Single submitter ⚠
- p.Ala127Ser Single submitter ⚠
- p.Ala127Thr Single submitter ⚠
- p.Ala128Ser Single submitter ⚠
- p.Ala139Thr Single submitter ⚠
- p.Ala13Pro Single submitter ⚠
- p.Ala13Val Single submitter ⚠
- p.Ala170Pro Single submitter ⚠
- p.Ala178Val Single submitter ⚠
- p.Ala81Ser Single submitter ⚠
- p.Ala97Ser Single submitter ⚠
- p.Arg187His Single submitter ⚠
- p.Arg216Leu Single submitter ⚠
- p.Asp75His Single submitter ⚠
- p.Cys24Tyr Single submitter ⚠
- p.Glu153Lys Single submitter ⚠
- p.Glu188Gly Single submitter ⚠
- p.Gly36Ser Single submitter ⚠
- p.Ile143Asn Single submitter ⚠
- p.Leu125Val Single submitter ⚠
- p.Leu130Phe Single submitter ⚠
- p.Lys189Asn Single submitter ⚠
- p.Met28Ile Single submitter ⚠
- p.Pro186Ser Single submitter ⚠
- p.Ser2Thr Single submitter ⚠
- p.Ser42Trp Single submitter ⚠
- p.Thr192Lys Single submitter ⚠
- p.Thr204Ser Single submitter ⚠
- p.Thr212Ser Single submitter ⚠
- p.Val165Leu Single submitter ⚠
- p.Val22Leu Single submitter ⚠
- p.Val22Met Single submitter ⚠
- p.Val31Leu Single submitter ⚠
- p.Val84Leu Single submitter ⚠