CLDN34 — 27 ClinVar variants
All ClinVar germline CLDN34 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
4 Likely benign · 23 Uncertain significance
Full CLDN34 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLDN34 p.Ala105Gly Uncertain significance Single submitter
- CLDN34 p.Arg63Cys Uncertain significance Single submitter
- CLDN34 p.Arg63Gly Uncertain significance Single submitter
- CLDN34 p.Arg63Leu Uncertain significance Single submitter
- CLDN34 p.Cys5Gly Uncertain significance Single submitter
- CLDN34 p.Gln78Arg Uncertain significance Single submitter
- CLDN34 p.Gly205Ser Uncertain significance Single submitter
- CLDN34 p.His208Tyr Uncertain significance Single submitter
- CLDN34 p.Met108Val Uncertain significance Single submitter
- CLDN34 p.Met189Ile Uncertain significance Single submitter
- CLDN34 p.Phe84Val Uncertain significance Single submitter
- CLDN34 p.Pro47Ala Uncertain significance Single submitter
- CLDN34 p.Pro47Thr Uncertain significance Single submitter
- CLDN34 p.Thr64Ser Uncertain significance Single submitter
- CLDN34 p.Tyr124Cys Uncertain significance Single submitter
- CLDN34 p.Tyr77His Uncertain significance Single submitter
- CLDN34 p.Val175Ala Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CLDN34 p.Ala137Val Uncertain significance Single submitter
- CLDN34 p.Ala50Thr Uncertain significance Single submitter
- CLDN34 p.Arg74Gln Uncertain significance Single submitter
- CLDN34 p.Cys58Arg Uncertain significance Single submitter
- CLDN34 p.Met189Arg Uncertain significance Single submitter
- CLDN34 p.Phe71Leu Uncertain significance Single submitter
- CLDN34 p.Phe92Leu Likely benign Single submitter
All CLDN34 variants
Likely benign 4
- p.Met114Val Single submitter
- p.Phe92Leu Single submitter ⚠
- p.Pro188Leu Single submitter
- p.Thr18Ala Single submitter
Uncertain significance 23
- p.Ala105Gly Single submitter ⚠
- p.Ala137Val Single submitter ⚠
- p.Ala50Thr Single submitter ⚠
- p.Arg63Cys Single submitter ⚠
- p.Arg63Gly Single submitter ⚠
- p.Arg63Leu Single submitter ⚠
- p.Arg74Gln Single submitter ⚠
- p.Cys58Arg Single submitter ⚠
- p.Cys5Gly Single submitter ⚠
- p.Gln78Arg Single submitter ⚠
- p.Gly205Ser Single submitter ⚠
- p.His208Tyr Single submitter ⚠
- p.Met108Val Single submitter ⚠
- p.Met189Arg Single submitter ⚠
- p.Met189Ile Single submitter ⚠
- p.Phe71Leu Single submitter ⚠
- p.Phe84Val Single submitter ⚠
- p.Pro47Ala Single submitter ⚠
- p.Pro47Thr Single submitter ⚠
- p.Thr64Ser Single submitter ⚠
- p.Tyr124Cys Single submitter ⚠
- p.Tyr77His Single submitter ⚠
- p.Val175Ala Single submitter ⚠