CLDN4 — 27 ClinVar variants
All ClinVar germline CLDN4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
2 Likely benign · 25 Uncertain significance
Full CLDN4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLDN4 p.Ala121Gly Uncertain significance Single submitter
- CLDN4 p.Ala12Pro Uncertain significance Single submitter
- CLDN4 p.Arg81His Uncertain significance Single submitter
- CLDN4 p.Cys107Gly Uncertain significance Single submitter
- CLDN4 p.Cys64Arg Uncertain significance Single submitter
- CLDN4 p.Gly155Arg Uncertain significance Single submitter
- CLDN4 p.Gly167Ser Uncertain significance Single submitter
- CLDN4 p.Gly167Val Uncertain significance Single submitter
- CLDN4 p.Ile133Leu Uncertain significance Single submitter
- CLDN4 p.Leu130Phe Uncertain significance Single submitter
- CLDN4 p.Leu173Pro Uncertain significance Single submitter
- CLDN4 p.Leu73Gln Uncertain significance Single submitter
- CLDN4 p.Phe35Leu Uncertain significance Single submitter
- CLDN4 p.Pro74Leu Uncertain significance Single submitter
- CLDN4 p.Ser43Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- CLDN4 p.Ala113Thr Uncertain significance Single submitter
- CLDN4 p.Ala82Thr Uncertain significance Single submitter
- CLDN4 p.Asp190Asn Uncertain significance Single submitter
- CLDN4 p.Asp76Glu Uncertain significance Single submitter
- CLDN4 p.Leu77Gln Uncertain significance Single submitter
- CLDN4 p.Met29Thr Uncertain significance Single submitter
- CLDN4 p.Pro187His Uncertain significance Single submitter
- CLDN4 p.Val21Ile Uncertain significance Single submitter
- CLDN4 p.Val90Met Uncertain significance Single submitter
- CLDN4 p.Val95Ala Uncertain significance Single submitter
All CLDN4 variants
Likely benign 2
- p.Ile11= Single submitter
- p.Ile133Met Single submitter
Uncertain significance 25
- p.Ala113Thr Single submitter ⚠
- p.Ala121Gly Single submitter ⚠
- p.Ala12Pro Single submitter ⚠
- p.Ala82Thr Single submitter ⚠
- p.Arg81His Single submitter ⚠
- p.Asp190Asn Single submitter ⚠
- p.Asp76Glu Single submitter ⚠
- p.Cys107Gly Single submitter ⚠
- p.Cys64Arg Single submitter ⚠
- p.Gly155Arg Single submitter ⚠
- p.Gly167Ser Single submitter ⚠
- p.Gly167Val Single submitter ⚠
- p.Ile133Leu Single submitter ⚠
- p.Leu130Phe Single submitter ⚠
- p.Leu173Pro Single submitter ⚠
- p.Leu73Gln Single submitter ⚠
- p.Leu77Gln Single submitter ⚠
- p.Met29Thr Single submitter ⚠
- p.Phe35Leu Single submitter ⚠
- p.Pro187His Single submitter ⚠
- p.Pro74Leu Single submitter ⚠
- p.Ser43Leu Single submitter ⚠
- p.Val21Ile Single submitter ⚠
- p.Val90Met Single submitter ⚠
- p.Val95Ala Single submitter ⚠