CLDN6 — 42 ClinVar variants
All ClinVar germline CLDN6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
1 Benign · 4 Likely benign · 37 Uncertain significance
Full CLDN6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLDN6 p.Ala169Val Uncertain significance Single submitter
- CLDN6 p.Arg81Cys Uncertain significance Single submitter
- CLDN6 p.Asp68Asn Uncertain significance Single submitter
- CLDN6 p.Cys107Ser Uncertain significance Single submitter
- CLDN6 p.Cys54Arg Uncertain significance Single submitter
- CLDN6 p.Glu109Lys Uncertain significance Single submitter
- CLDN6 p.Glu213Lys Uncertain significance Single submitter
- CLDN6 p.Gly101Arg Uncertain significance Single submitter
- CLDN6 p.Gly178Arg Uncertain significance Single submitter
- CLDN6 p.Ile127Phe Uncertain significance Single submitter
- CLDN6 p.Ile127Val Uncertain significance Single submitter
- CLDN6 p.Ile134Thr Uncertain significance Single submitter
- CLDN6 p.Ile144Leu Uncertain significance Single submitter
- CLDN6 p.Leu99Val Uncertain significance Single submitter
- CLDN6 p.Met197Ile Uncertain significance Single submitter
- CLDN6 p.Pro135Arg Uncertain significance Single submitter
- CLDN6 p.Pro215Thr Uncertain significance Single submitter
- CLDN6 p.Thr132Met Uncertain significance Single submitter
- CLDN6 p.Trp47Arg Uncertain significance Single submitter
- CLDN6 p.Val41Leu Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- CLDN6 p.Ala155Thr Uncertain significance Single submitter
- CLDN6 p.Ala162Ser Uncertain significance Single submitter
- CLDN6 p.Ala72Val Uncertain significance Single submitter
- CLDN6 p.Ala87Thr Likely benign Single submitter
- CLDN6 p.Arg116Cys Uncertain significance Single submitter
- CLDN6 p.Arg145Gln Likely benign Single submitter
- CLDN6 p.Arg199Cys Uncertain significance Single submitter
- CLDN6 p.Arg199His Uncertain significance Single submitter
- CLDN6 p.Arg209Trp Uncertain significance Single submitter
- CLDN6 p.Glu109Gly Uncertain significance Single submitter
- CLDN6 p.Gly189Trp Uncertain significance Single submitter
- CLDN6 p.His141Arg Uncertain significance Single submitter
- CLDN6 p.Leu27Val Uncertain significance Single submitter
- CLDN6 p.Leu96Met Uncertain significance Single submitter
- CLDN6 p.Pro205Leu Uncertain significance Single submitter
- CLDN6 p.Pro211Leu Uncertain significance Single submitter
- CLDN6 p.Ser187Leu Uncertain significance Single submitter
- CLDN6 p.Tyr148Cys Uncertain significance Single submitter
- CLDN6 p.Val136Met Uncertain significance Single submitter
All CLDN6 variants
Benign 1
- p.Thr14= Multiple submitters
Likely benign 4
- p.Ala87Thr Single submitter ⚠
- p.Arg145Gln Single submitter ⚠
- p.Gly21Ala Single submitter
- p.Val11Ile Single submitter
Uncertain significance 37
- p.Ala155Thr Single submitter ⚠
- p.Ala162Ser Single submitter ⚠
- p.Ala169Val Single submitter ⚠
- p.Ala72Val Single submitter ⚠
- p.Arg116Cys Single submitter ⚠
- p.Arg199Cys Single submitter ⚠
- p.Arg199His Single submitter ⚠
- p.Arg209Trp Single submitter ⚠
- p.Arg81Cys Single submitter ⚠
- p.Asp68Asn Single submitter ⚠
- p.Cys107Ser Single submitter ⚠
- p.Cys54Arg Single submitter ⚠
- p.Glu109Gly Single submitter ⚠
- p.Glu109Lys Single submitter ⚠
- p.Glu213Lys Single submitter ⚠
- p.Gly101Arg Single submitter ⚠
- p.Gly178Arg Single submitter ⚠
- p.Gly189Trp Single submitter ⚠
- p.His141Arg Single submitter ⚠
- p.Ile127Phe Single submitter ⚠
- p.Ile127Val Single submitter ⚠
- p.Ile134Thr Single submitter ⚠
- p.Ile144Leu Single submitter ⚠
- p.Leu27Val Single submitter ⚠
- p.Leu96Met Single submitter ⚠
- p.Leu99Val Single submitter ⚠
- p.Met197Ile Single submitter ⚠
- p.Pro135Arg Single submitter ⚠
- p.Pro205Leu Single submitter ⚠
- p.Pro211Leu Single submitter ⚠
- p.Pro215Thr Single submitter ⚠
- p.Ser187Leu Single submitter ⚠
- p.Thr132Met Single submitter ⚠
- p.Trp47Arg Single submitter ⚠
- p.Tyr148Cys Single submitter ⚠
- p.Val136Met Single submitter ⚠
- p.Val41Leu Single submitter ⚠