CLDN7 — 34 ClinVar variants
All ClinVar germline CLDN7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
6 Likely benign · 28 Uncertain significance
Full CLDN7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLDN7 p.Ala133Pro Uncertain significance Single submitter
- CLDN7 p.Ala79Asp Uncertain significance Single submitter
- CLDN7 p.Arg199Gly Uncertain significance Single submitter
- CLDN7 p.Asn39Ile Uncertain significance Single submitter
- CLDN7 p.Asn3Ser Uncertain significance Single submitter
- CLDN7 p.Cys184Tyr Uncertain significance Single submitter
- CLDN7 p.Ile144Thr Uncertain significance Single submitter
- CLDN7 p.Leu131Val Uncertain significance Single submitter
- CLDN7 p.Leu6Pro Uncertain significance Single submitter
- CLDN7 p.Leu88Pro Uncertain significance Single submitter
- CLDN7 p.Lys48Arg Uncertain significance Single submitter
- CLDN7 p.Met100Thr Uncertain significance Single submitter
- CLDN7 p.Phe96Ser Uncertain significance Single submitter
- CLDN7 p.Pro28Leu Uncertain significance Single submitter
- CLDN7 p.Thr99Ala Uncertain significance Single submitter
- CLDN7 p.Val175Leu Uncertain significance Single submitter
- CLDN7 p.Val86Phe Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- CLDN7 p.Ala170Thr Uncertain significance Single submitter
- CLDN7 p.Ala180Thr Uncertain significance Single submitter
- CLDN7 p.Arg106Leu Uncertain significance Single submitter
- CLDN7 p.Arg199Cys Uncertain significance Single submitter
- CLDN7 p.Cys184Gly Uncertain significance Single submitter
- CLDN7 p.Gly109Ala Uncertain significance Single submitter
- CLDN7 p.Leu131Phe Uncertain significance Single submitter
- CLDN7 p.Leu90Val Uncertain significance Single submitter
- CLDN7 p.Pro151Ser Uncertain significance Single submitter
- CLDN7 p.Pro187Ser Uncertain significance Single submitter
- CLDN7 p.Pro198Leu Uncertain significance Single submitter
All CLDN7 variants
Likely benign 6
Uncertain significance 28
- p.Ala133Pro Single submitter ⚠
- p.Ala170Thr Single submitter ⚠
- p.Ala180Thr Single submitter ⚠
- p.Ala79Asp Single submitter ⚠
- p.Arg106Leu Single submitter ⚠
- p.Arg199Cys Single submitter ⚠
- p.Arg199Gly Single submitter ⚠
- p.Asn39Ile Single submitter ⚠
- p.Asn3Ser Single submitter ⚠
- p.Cys184Gly Single submitter ⚠
- p.Cys184Tyr Single submitter ⚠
- p.Gly109Ala Single submitter ⚠
- p.Ile144Thr Single submitter ⚠
- p.Leu131Phe Single submitter ⚠
- p.Leu131Val Single submitter ⚠
- p.Leu6Pro Single submitter ⚠
- p.Leu88Pro Single submitter ⚠
- p.Leu90Val Single submitter ⚠
- p.Lys48Arg Single submitter ⚠
- p.Met100Thr Single submitter ⚠
- p.Phe96Ser Single submitter ⚠
- p.Pro151Ser Single submitter ⚠
- p.Pro187Ser Single submitter ⚠
- p.Pro198Leu Single submitter ⚠
- p.Pro28Leu Single submitter ⚠
- p.Thr99Ala Single submitter ⚠
- p.Val175Leu Single submitter ⚠
- p.Val86Phe Single submitter ⚠