CLDND1 — 42 ClinVar variants
All ClinVar germline CLDND1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
42 Uncertain significance
Full CLDND1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLDND1 p.Ala249Pro Uncertain significance Single submitter
- CLDND1 p.Arg241Trp Uncertain significance Single submitter
- CLDND1 p.Arg251Pro Uncertain significance Single submitter
- CLDND1 p.Asn72Ser Uncertain significance Single submitter
- CLDND1 p.Asp206Gly Uncertain significance Single submitter
- CLDND1 p.Asp30Tyr Uncertain significance Single submitter
- CLDND1 p.Asp57Gly Uncertain significance Single submitter
- CLDND1 p.Asp66Asn Uncertain significance Single submitter
- CLDND1 p.Glu117Asp Uncertain significance Single submitter
- CLDND1 p.Gly210Ser Uncertain significance Single submitter
- CLDND1 p.Ile171Val Uncertain significance Single submitter
- CLDND1 p.Ile27Val Uncertain significance Single submitter
- CLDND1 p.Ile55Val Uncertain significance Single submitter
- CLDND1 p.Lys201Arg Uncertain significance Single submitter
- CLDND1 p.Lys86Glu Uncertain significance Single submitter
- CLDND1 p.Met116Leu Uncertain significance Single submitter
- CLDND1 p.Phe100Ser Uncertain significance Single submitter
- CLDND1 p.Pro38Leu Uncertain significance Single submitter
- CLDND1 p.Pro85Arg Uncertain significance Single submitter
- CLDND1 p.Ser49Thr Uncertain significance Single submitter
- CLDND1 p.Thr170Ala Uncertain significance Single submitter
- CLDND1 p.Thr63Asn Uncertain significance Single submitter
- CLDND1 p.Val103Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- CLDND1 p.Ala24Thr Uncertain significance Single submitter
- CLDND1 p.Ala25Val Uncertain significance Single submitter
- CLDND1 p.Ala8Gly Uncertain significance Single submitter
- CLDND1 p.Gln226Glu Uncertain significance Single submitter
- CLDND1 p.Glu61Gly Uncertain significance Single submitter
- CLDND1 p.Gly194Glu Uncertain significance Single submitter
- CLDND1 p.Leu15Phe Uncertain significance Single submitter
- CLDND1 p.Phe119Leu Uncertain significance Single submitter
- CLDND1 p.Thr20Ile Uncertain significance Single submitter
- CLDND1 p.Tyr71Cys Uncertain significance Single submitter
- CLDND1 p.Val146Met Uncertain significance Single submitter
All CLDND1 variants
Uncertain significance 42
- c.-18-215C>A Single submitter
- c.-18-227T>C Single submitter
- c.-18-230C>T Single submitter
- c.-18-237A>C Single submitter
- c.-18-242A>T Single submitter
- c.-18-243G>C Single submitter
- c.-18-254G>A Single submitter
- p.Ala229Ser Single submitter
- p.Ala249Pro Single submitter ⚠
- p.Ala24Thr Single submitter ⚠
- p.Ala25Val Single submitter ⚠
- p.Ala8Gly Single submitter ⚠
- p.Arg241Trp Single submitter ⚠
- p.Arg251Pro Single submitter ⚠
- p.Asn72Ser Single submitter ⚠
- p.Asp206Gly Single submitter ⚠
- p.Asp30Tyr Single submitter ⚠
- p.Asp57Gly Single submitter ⚠
- p.Asp66Asn Single submitter ⚠
- p.Gln226Glu Single submitter ⚠
- p.Glu117Asp Single submitter ⚠
- p.Glu61Gly Single submitter ⚠
- p.Gly194Glu Single submitter ⚠
- p.Gly210Ser Single submitter ⚠
- p.Ile171Val Single submitter ⚠
- p.Ile27Val Single submitter ⚠
- p.Ile55Val Single submitter ⚠
- p.Leu15Phe Single submitter ⚠
- p.Lys201Arg Single submitter ⚠
- p.Lys86Glu Single submitter ⚠
- p.Met116Leu Single submitter ⚠
- p.Phe100Ser Single submitter ⚠
- p.Phe119Leu Single submitter ⚠
- p.Pro38Leu Single submitter ⚠
- p.Pro85Arg Single submitter ⚠
- p.Ser49Thr Single submitter ⚠
- p.Thr170Ala Single submitter ⚠
- p.Thr20Ile Single submitter ⚠
- p.Thr63Asn Single submitter ⚠
- p.Tyr71Cys Single submitter ⚠
- p.Val103Ile Single submitter ⚠
- p.Val146Met Single submitter ⚠