CLDND2 — 29 ClinVar variants
All ClinVar germline CLDND2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
1 Benign · 1 Likely benign · 27 Uncertain significance
Full CLDND2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLDND2 p.Ala136Pro Uncertain significance Single submitter
- CLDND2 p.Ala64Val Uncertain significance Single submitter
- CLDND2 p.Arg5Trp Uncertain significance Single submitter
- CLDND2 p.Arg92Gln Uncertain significance Single submitter
- CLDND2 p.Cys55Phe Uncertain significance Single submitter
- CLDND2 p.Glu89Lys Uncertain significance Single submitter
- CLDND2 p.Gly10Glu Uncertain significance Single submitter
- CLDND2 p.Gly144Ala Uncertain significance Single submitter
- CLDND2 p.Gly80Arg Uncertain significance Single submitter
- CLDND2 p.Ile12Leu Uncertain significance Single submitter
- CLDND2 p.Ile53Val Uncertain significance Single submitter
- CLDND2 p.Leu24Val Uncertain significance Single submitter
- CLDND2 p.Leu7His Uncertain significance Single submitter
- CLDND2 p.Met77Ile Uncertain significance Single submitter
- CLDND2 p.Pro54His Uncertain significance Single submitter
- CLDND2 p.Ser6Gly Uncertain significance Single submitter
- CLDND2 p.Thr95Ser Uncertain significance Single submitter
- CLDND2 p.Val20Asp Uncertain significance Single submitter
- CLDND2 p.Val74Ala Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- CLDND2 p.Arg33Cys Uncertain significance Single submitter
- CLDND2 p.Gly76Ser Uncertain significance Single submitter
- CLDND2 p.Phe125Cys Uncertain significance Single submitter
- CLDND2 p.Ser156Arg Uncertain significance Single submitter
- CLDND2 p.Ser161Gly Uncertain significance Single submitter
- CLDND2 p.Ser97Asn Uncertain significance Single submitter
- CLDND2 p.Tyr130Cys Uncertain significance Single submitter
- CLDND2 p.Tyr30Asn Uncertain significance Single submitter
All CLDND2 variants
Benign 1
- p.Ala143= Single submitter
Likely benign 1
- p.Thr157= Multiple submitters
Uncertain significance 27
- p.Ala136Pro Single submitter ⚠
- p.Ala64Val Single submitter ⚠
- p.Arg33Cys Single submitter ⚠
- p.Arg5Trp Single submitter ⚠
- p.Arg92Gln Single submitter ⚠
- p.Cys55Phe Single submitter ⚠
- p.Glu89Lys Single submitter ⚠
- p.Gly10Glu Single submitter ⚠
- p.Gly144Ala Single submitter ⚠
- p.Gly76Ser Single submitter ⚠
- p.Gly80Arg Single submitter ⚠
- p.Ile12Leu Single submitter ⚠
- p.Ile53Val Single submitter ⚠
- p.Leu24Val Single submitter ⚠
- p.Leu7His Single submitter ⚠
- p.Met77Ile Single submitter ⚠
- p.Phe125Cys Single submitter ⚠
- p.Pro54His Single submitter ⚠
- p.Ser156Arg Single submitter ⚠
- p.Ser161Gly Single submitter ⚠
- p.Ser6Gly Single submitter ⚠
- p.Ser97Asn Single submitter ⚠
- p.Thr95Ser Single submitter ⚠
- p.Tyr130Cys Single submitter ⚠
- p.Tyr30Asn Single submitter ⚠
- p.Val20Asp Single submitter ⚠
- p.Val74Ala Single submitter ⚠