CLEC10A — 35 ClinVar variants
All ClinVar germline CLEC10A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
1 Benign · 1 Benign/Likely benign · 4 Likely benign · 29 Uncertain significance
Full CLEC10A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLEC10A c.353-27C>T Uncertain significance Single submitter
- CLEC10A c.353-34C>T Uncertain significance Single submitter
- CLEC10A c.353-46G>A Uncertain significance Single submitter
- CLEC10A c.353-61C>T Uncertain significance Single submitter
- CLEC10A c.353-79G>T Uncertain significance Single submitter
- CLEC10A p.Ala187Thr Uncertain significance Single submitter
- CLEC10A p.Ala85Thr Uncertain significance Single submitter
- CLEC10A p.Arg125Gln Uncertain significance Single submitter
- CLEC10A p.Arg33Pro Uncertain significance Single submitter
- CLEC10A p.Arg3Gly Uncertain significance Single submitter
- CLEC10A p.Asn144Ser Uncertain significance Single submitter
- CLEC10A p.Asn193Ser Uncertain significance Single submitter
- CLEC10A p.Asp243Asn Uncertain significance Single submitter
- CLEC10A p.Asp254Asn Uncertain significance Single submitter
- CLEC10A p.Asp267Asn Uncertain significance Single submitter
- CLEC10A p.Glu177Gly Uncertain significance Single submitter
- CLEC10A p.Gly252Asp Uncertain significance Single submitter
- CLEC10A p.Gly262Val Uncertain significance Single submitter
- CLEC10A p.Met173Leu Uncertain significance Single submitter
- CLEC10A p.Ser164Asn Uncertain significance Single submitter
- CLEC10A p.Thr149Ala Uncertain significance Single submitter
- CLEC10A p.Thr210Ile Uncertain significance Single submitter
- CLEC10A p.Thr80Ile Uncertain significance Single submitter
- CLEC10A p.Thr83Ala Uncertain significance Single submitter
- CLEC10A p.Val159Met Uncertain significance Single submitter
- CLEC10A p.Val268Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All CLEC10A variants
Benign 1
- p.Ala176Gly Multiple submitters
Benign/Likely benign 1
- p.Cys138Arg Multiple submitters ⚠
Likely benign 4
- p.Arg33His Single submitter
- p.Gly280Ser Single submitter
- p.Ile87Val Single submitter
- p.Val156Ile Single submitter
Uncertain significance 29
- c.353-27C>T Single submitter ⚠
- c.353-34C>T Single submitter ⚠
- c.353-46G>A Single submitter ⚠
- c.353-61C>T Single submitter ⚠
- c.353-79G>T Single submitter ⚠
- p.Ala187Thr Single submitter ⚠
- p.Ala256Thr Single submitter ⚠
- p.Ala85Thr Single submitter ⚠
- p.Arg125Gln Single submitter ⚠
- p.Arg33Pro Single submitter ⚠
- p.Arg3Gly Single submitter ⚠
- p.Asn144Ser Single submitter ⚠
- p.Asn193Ser Single submitter ⚠
- p.Asp243Asn Single submitter ⚠
- p.Asp254Asn Single submitter ⚠
- p.Asp267Asn Single submitter ⚠
- p.Glu177Gly Single submitter ⚠
- p.Gly252Asp Single submitter ⚠
- p.Gly262Ala Single submitter ⚠
- p.Gly262Val Single submitter ⚠
- p.Met173Leu Single submitter ⚠
- p.Phe258Leu Single submitter ⚠
- p.Ser164Asn Single submitter ⚠
- p.Thr149Ala Single submitter ⚠
- p.Thr210Ile Single submitter ⚠
- p.Thr80Ile Single submitter ⚠
- p.Thr83Ala Single submitter ⚠
- p.Val159Met Single submitter ⚠
- p.Val268Ile Single submitter ⚠