CLEC11A — 56 ClinVar variants
All ClinVar germline CLEC11A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
1 Likely benign · 55 Uncertain significance
Full CLEC11A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLEC11A p.Ala116Gly Uncertain significance Single submitter
- CLEC11A p.Ala206Glu Uncertain significance Single submitter
- CLEC11A p.Ala247Thr Uncertain significance Single submitter
- CLEC11A p.Ala263Val Uncertain significance Single submitter
- CLEC11A p.Arg169His Uncertain significance Single submitter
- CLEC11A p.Arg203Trp Uncertain significance Single submitter
- CLEC11A p.Arg225Leu Uncertain significance Single submitter
- CLEC11A p.Arg23Pro Uncertain significance Single submitter
- CLEC11A p.Arg23Trp Uncertain significance Single submitter
- CLEC11A p.Arg246His Uncertain significance Single submitter
- CLEC11A p.Arg313Gln Uncertain significance Single submitter
- CLEC11A p.Arg41Gln Uncertain significance Single submitter
- CLEC11A p.Arg41Trp Uncertain significance Single submitter
- CLEC11A p.Arg61Ser Uncertain significance Single submitter
- CLEC11A p.Asn65Thr Uncertain significance Single submitter
- CLEC11A p.Asp119Glu Uncertain significance Single submitter
- CLEC11A p.Asp216Gly Uncertain significance Single submitter
- CLEC11A p.Cys187Tyr Uncertain significance Single submitter
- CLEC11A p.Glu175Gln Uncertain significance Single submitter
- CLEC11A p.Glu28Asp Uncertain significance Single submitter
- CLEC11A p.Glu71Ala Uncertain significance Single submitter
- CLEC11A p.Gly165Val Uncertain significance Single submitter
- CLEC11A p.Gly21Arg Uncertain significance Single submitter
- CLEC11A p.Gly273Arg Uncertain significance Single submitter
- CLEC11A p.Gly32Val Uncertain significance Single submitter
- CLEC11A p.Gly97Arg Uncertain significance Single submitter
- CLEC11A p.His185Gln Uncertain significance Single submitter
- CLEC11A p.Leu174Val Uncertain significance Single submitter
- CLEC11A p.Leu223Val Uncertain significance Single submitter
- CLEC11A p.Leu272Ile Uncertain significance Single submitter
- CLEC11A p.Leu283Pro Uncertain significance Single submitter
- CLEC11A p.Lys179Arg Uncertain significance Single submitter
- CLEC11A p.Met220Val Uncertain significance Single submitter
- CLEC11A p.Pro102Leu Uncertain significance Single submitter
- CLEC11A p.Pro282Gln Uncertain significance Single submitter
- CLEC11A p.Pro285Ala Uncertain significance Single submitter
- CLEC11A p.Pro94Ser Uncertain significance Single submitter
- CLEC11A p.Ser210Asn Uncertain significance Single submitter
- CLEC11A p.Ser277Arg Uncertain significance Single submitter
- CLEC11A p.Thr224Ile Uncertain significance Single submitter
- CLEC11A p.Thr69Asn Uncertain significance Single submitter
- CLEC11A p.Thr91Lys Uncertain significance Single submitter
- CLEC11A p.Tyr251Cys Uncertain significance Single submitter
- CLEC11A p.Val11Met Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- CLEC11A p.Ala131Pro Uncertain significance Single submitter
- CLEC11A p.Ala212Pro Uncertain significance Single submitter
- CLEC11A p.Ala212Val Uncertain significance Single submitter
- CLEC11A p.Arg217Cys Uncertain significance Single submitter
- CLEC11A p.Glu175Lys Uncertain significance Single submitter
- CLEC11A p.Glu195Lys Uncertain significance Single submitter
- CLEC11A p.Phe321Leu Uncertain significance Single submitter
- CLEC11A p.Ser210Ile Uncertain significance Single submitter
- CLEC11A p.Thr153Pro Uncertain significance Single submitter
All CLEC11A variants
Likely benign 1
- p.Ala278fs Single submitter
Uncertain significance 55
- p.Ala116Gly Single submitter ⚠
- p.Ala131Pro Single submitter ⚠
- p.Ala206Glu Single submitter ⚠
- p.Ala212Pro Single submitter ⚠
- p.Ala212Val Single submitter ⚠
- p.Ala247Thr Single submitter ⚠
- p.Ala263Val Single submitter ⚠
- p.Arg169His Single submitter ⚠
- p.Arg203Trp Single submitter ⚠
- p.Arg207Leu Single submitter
- p.Arg217Cys Single submitter ⚠
- p.Arg225Leu Single submitter ⚠
- p.Arg23Pro Single submitter ⚠
- p.Arg23Trp Single submitter ⚠
- p.Arg246His Single submitter ⚠
- p.Arg313Gln Single submitter ⚠
- p.Arg41Gln Single submitter ⚠
- p.Arg41Trp Single submitter ⚠
- p.Arg61Ser Single submitter ⚠
- p.Asn65Thr Single submitter ⚠
- p.Asp119Glu Single submitter ⚠
- p.Asp216Gly Single submitter ⚠
- p.Cys187Tyr Single submitter ⚠
- p.Glu175Gln Single submitter ⚠
- p.Glu175Lys Single submitter ⚠
- p.Glu195Lys Single submitter ⚠
- p.Glu28Asp Single submitter ⚠
- p.Glu71Ala Single submitter ⚠
- p.Gly165Val Single submitter ⚠
- p.Gly21Arg Single submitter ⚠
- p.Gly273Arg Single submitter ⚠
- p.Gly291Asp Single submitter
- p.Gly32Val Single submitter ⚠
- p.Gly97Arg Single submitter ⚠
- p.His185Gln Single submitter ⚠
- p.Leu174Val Single submitter ⚠
- p.Leu223Val Single submitter ⚠
- p.Leu272Ile Single submitter ⚠
- p.Leu283Pro Single submitter ⚠
- p.Lys179Arg Single submitter ⚠
- p.Met220Val Single submitter ⚠
- p.Phe321Leu Single submitter ⚠
- p.Pro102Leu Single submitter ⚠
- p.Pro282Gln Single submitter ⚠
- p.Pro285Ala Single submitter ⚠
- p.Pro94Ser Single submitter ⚠
- p.Ser210Asn Single submitter ⚠
- p.Ser210Ile Single submitter ⚠
- p.Ser277Arg Single submitter ⚠
- p.Thr153Pro Single submitter ⚠
- p.Thr224Ile Single submitter ⚠
- p.Thr69Asn Single submitter ⚠
- p.Thr91Lys Single submitter ⚠
- p.Tyr251Cys Single submitter ⚠
- p.Val11Met Single submitter ⚠