CLEC12A — 39 ClinVar variants
All ClinVar germline CLEC12A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
6 Likely benign · 33 Uncertain significance
Full CLEC12A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLEC12A p.Ala163Thr Uncertain significance Single submitter
- CLEC12A p.Ala166Val Uncertain significance Single submitter
- CLEC12A p.Ala176Ser Uncertain significance Single submitter
- CLEC12A p.Arg119Cys Uncertain significance Single submitter
- CLEC12A p.Asn101Ser Uncertain significance Single submitter
- CLEC12A p.Asn105Lys Uncertain significance Single submitter
- CLEC12A p.Asn173Lys Uncertain significance Single submitter
- CLEC12A p.Asp198Glu Uncertain significance Single submitter
- CLEC12A p.Gln183Arg Uncertain significance Single submitter
- CLEC12A p.Glu196Gly Uncertain significance Single submitter
- CLEC12A p.Glu23Asp Uncertain significance Single submitter
- CLEC12A p.Gly25Ser Uncertain significance Single submitter
- CLEC12A p.Ile247Val Uncertain significance Single submitter
- CLEC12A p.Ile89Ser Uncertain significance Single submitter
- CLEC12A p.Ile99Val Uncertain significance Single submitter
- CLEC12A p.Leu193Phe Uncertain significance Single submitter
- CLEC12A p.Lys124Arg Uncertain significance Single submitter
- CLEC12A p.Lys124Glu Uncertain significance Single submitter
- CLEC12A p.Lys30Thr Uncertain significance Single submitter
- CLEC12A p.Met203Arg Uncertain significance Single submitter
- CLEC12A p.Met203Thr Uncertain significance Single submitter
- CLEC12A p.Met72Thr Uncertain significance Single submitter
- CLEC12A p.Met75Val Uncertain significance Single submitter
- CLEC12A p.Pro33Ala Uncertain significance Single submitter
- CLEC12A p.Thr108Ala Uncertain significance Single submitter
- CLEC12A p.Thr112Ile Uncertain significance Single submitter
- CLEC12A p.Trp190Cys Uncertain significance Single submitter
- CLEC12A p.Tyr145Cys Uncertain significance Single submitter
- CLEC12A p.Val151Gly Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All CLEC12A variants
Likely benign 6
- p.Ala219Thr Single submitter
- p.Ile89Val Single submitter
- p.Pro220Ser Single submitter
- p.Ser259Phe Single submitter
- p.Thr260Ile Single submitter
- p.Tyr261His Single submitter
Uncertain significance 33
- c.-3T>C Single submitter
- p.Ala163Thr Single submitter ⚠
- p.Ala166Asp Single submitter ⚠
- p.Ala166Val Single submitter ⚠
- p.Ala176Ser Single submitter ⚠
- p.Arg119Cys Single submitter ⚠
- p.Asn101Ser Single submitter ⚠
- p.Asn105Lys Single submitter ⚠
- p.Asn173Lys Single submitter ⚠
- p.Asp198Glu Single submitter ⚠
- p.Gln183Arg Single submitter ⚠
- p.Glu196Gly Single submitter ⚠
- p.Glu23Asp Single submitter ⚠
- p.Gly25Ser Single submitter ⚠
- p.His140Pro Single submitter ⚠
- p.Ile247Val Single submitter ⚠
- p.Ile89Ser Single submitter ⚠
- p.Ile99Val Single submitter ⚠
- p.Leu193Phe Single submitter ⚠
- p.Lys124Arg Single submitter ⚠
- p.Lys124Glu Single submitter ⚠
- p.Lys30Thr Single submitter ⚠
- p.Met203Arg Single submitter ⚠
- p.Met203Thr Single submitter ⚠
- p.Met72Thr Single submitter ⚠
- p.Met75Val Single submitter ⚠
- p.Pro33Ala Single submitter ⚠
- p.Thr108Ala Single submitter ⚠
- p.Thr112Ile Single submitter ⚠
- p.Trp190Cys Single submitter ⚠
- p.Tyr145Cys Single submitter ⚠
- p.Tyr7His Single submitter ⚠
- p.Val151Gly Single submitter ⚠