CLEC12B — 30 ClinVar variants
All ClinVar germline CLEC12B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
1 Likely benign · 29 Uncertain significance
Full CLEC12B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLEC12B p.Ala243Pro Uncertain significance Single submitter
- CLEC12B p.Ala8Gly Uncertain significance Single submitter
- CLEC12B p.Arg254His Uncertain significance Single submitter
- CLEC12B p.Asp174Ala Uncertain significance Single submitter
- CLEC12B p.Gln13His Uncertain significance Single submitter
- CLEC12B p.Gln66Arg Uncertain significance Single submitter
- CLEC12B p.Gln66Lys Uncertain significance Single submitter
- CLEC12B p.Glu232Gly Uncertain significance Single submitter
- CLEC12B p.Glu258Lys Uncertain significance Single submitter
- CLEC12B p.Gly238Arg Uncertain significance Single submitter
- CLEC12B p.Gly56Arg Uncertain significance Single submitter
- CLEC12B p.Ile250Val Uncertain significance Single submitter
- CLEC12B p.Ile38Val Uncertain significance Single submitter
- CLEC12B p.Ile55Thr Uncertain significance Single submitter
- CLEC12B p.Leu191Phe Uncertain significance Single submitter
- CLEC12B p.Lys126Asn Uncertain significance Single submitter
- CLEC12B p.Lys265Met Uncertain significance Single submitter
- CLEC12B p.Met62Thr Uncertain significance Single submitter
- CLEC12B p.Ser168Gly Uncertain significance Single submitter
- CLEC12B p.Thr266Ile Uncertain significance Single submitter
- CLEC12B p.Thr59Ile Uncertain significance Single submitter
- CLEC12B p.Trp208Arg Uncertain significance Single submitter
- CLEC12B p.Trp217Arg Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- CLEC12B p.Asp183His Uncertain significance Single submitter
- CLEC12B p.Cys140Phe Uncertain significance Single submitter
- CLEC12B p.Lys188Glu Uncertain significance Single submitter
- CLEC12B p.Ser221Cys Uncertain significance Single submitter
- CLEC12B p.Ser224Phe Uncertain significance Single submitter
- CLEC12B p.Tyr150Cys Uncertain significance Single submitter
All CLEC12B variants
Likely benign 1
- p.Asp171Asn Single submitter
Uncertain significance 29
- p.Ala243Pro Single submitter ⚠
- p.Ala8Gly Single submitter ⚠
- p.Arg254His Single submitter ⚠
- p.Asp174Ala Single submitter ⚠
- p.Asp183His Single submitter ⚠
- p.Cys140Phe Single submitter ⚠
- p.Gln13His Single submitter ⚠
- p.Gln66Arg Single submitter ⚠
- p.Gln66Lys Single submitter ⚠
- p.Glu232Gly Single submitter ⚠
- p.Glu258Lys Single submitter ⚠
- p.Gly238Arg Single submitter ⚠
- p.Gly56Arg Single submitter ⚠
- p.Ile250Val Single submitter ⚠
- p.Ile38Val Single submitter ⚠
- p.Ile55Thr Single submitter ⚠
- p.Leu191Phe Single submitter ⚠
- p.Lys126Asn Single submitter ⚠
- p.Lys188Glu Single submitter ⚠
- p.Lys265Met Single submitter ⚠
- p.Met62Thr Single submitter ⚠
- p.Ser168Gly Single submitter ⚠
- p.Ser221Cys Single submitter ⚠
- p.Ser224Phe Single submitter ⚠
- p.Thr266Ile Single submitter ⚠
- p.Thr59Ile Single submitter ⚠
- p.Trp208Arg Single submitter ⚠
- p.Trp217Arg Single submitter ⚠
- p.Tyr150Cys Single submitter ⚠